Results 181 to 190 of about 946,310 (305)

Photo‐Controlled Antibacterial Drug Release From DASA‐Coated Silica Particles for Improved Treatment of Wound Infections

Advanced Functional Materials, EarlyView.
Synthesis and characterization of light‐responsive donor–acceptor Stenhouse adducts (DASA)‐coated chlorhexidine‐loaded silica nanoparticles. Such a controllable drug‐delivery system enables the release of the antimicrobial drug on demand and in consecutive cycles, thereby maintaining the concentration within the therapeutic window.
Michèle Clerc, Flavia Zuber, Lea Oberhänsli, Yvonne Elbs‐Glatz, Maria M. Miguel, Vera M. Kissling, Qun Ren, Markus Rottmar, Luciano F. Boesel, Giorgia Giovannini   +9 more
wiley   +1 more source

N6-methyladenosine modification of NEU1 mediated by METTL3 exacerbates angiotensin II-induced atrial fibrillation. [PDF]

Cell Adh Migr
Zhang Z, Luo Y, Zou Q, Mo Z.
europepmc   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

Strategies for Loading and Releasing Peptide Therapeutics in Biodegradable Carriers

Advanced Functional Materials, EarlyView.
A biodegradable carrier‐based peptide delivery system is a powerful treatment platform for diverse diseases, owing to its superior therapeutic efficacy and low toxicity. This review examines the conventional peptide‐loaded carrier fabrication process and its current limitations.
Wookyoung Jang, Ki Wan Bong
wiley   +1 more source

Molecular Engineering of the Helminth TGF-β Mimetics, TGM1 and TGM4, Reveals a Novel Antagonist of TGF-β Signaling in Fibroblasts. [PDF]

FASEB J
Cunningham KT, Ciancia C, Campion T, van Dinther M, Davis N, Duffy A, Heawood ALL, Power L, Sanders A, Singh SP, Smyth DJ, Thompson E, White R, Hinck AP, Ten Dijke P, Maizels RM.   +15 more
europepmc   +1 more source

Amyloidogenic Peptide Fragments Designed From Bacterial Collagen‐like Proteins Form Hydrogel

Advanced Functional Materials, EarlyView.
This study identified amyloidogenic sequence motifs in bacterial collagen‐like proteins and exploited these to design peptides that self‐assemble into β‐sheet fibers and form hydrogels. One hydrogel supported healthy fibroblast growth, showing promise for biocompatible materials. Our work demonstrates that bacterial sequences can be harnessed to create
Vamika Sagar, Xuen J Ng, Lukas Lechel, Ashish Chand Rajwar, Hendrik Bargel, Abhishek A. Jalan   +5 more
wiley   +1 more source

SIRT3-mediated deacetylation of FoxM1 prevents pulmonary fibrosis via modulating the activation of pulmonary fibroblasts. [PDF]

Redox Biol
Dong J, Wang L, Wei A, Lin J, Xuan Y, Jiao Z, Bai Y, Shi X, Zhang Z, Sun W, Wang T, Chen X.   +11 more
europepmc   +1 more source

Genetically and metabolically corrected pluripotent stem cells from patients with mtDNA disease [PDF]

, 2015
Ahmed, Riffat, Amato, Paula, Belmonte, Juan Carlos Izpisua, Folmes, Clifford DL, Gutierrez, Nuria Marti, Hayama, Tomonari, Huang, Taosheng, Kang, Eunju, Koski, Amy, Laurent, Louise C, Lee, Yeonmi, Li, Ying, Ma, Hong, Ma, Li, Mitalipov, Nargiz, Mitalipov, Shoukhrat, Mora-Castilla, Sergio, Morey, Robert, Ocampo, Alejandro, Poulton, Joanna, Terzic, Andre, Tippner-Hedges, Rebecca, Van Dyken, Crystal, Wang, Xinjian, Wolf, Don P, Wu, Jun   +25 more
core   +1 more source

Swelling‐Programmed Topographical Guidance for Dynamic Spheroid Self‐Assembly via a Mechanochemical Hydrogel Niche

Advanced Functional Materials, EarlyView.
A swelling‐programmed micropatterned hydrogel guides adherent cells through a controlled transition from cell–matrix anchoring to cadherin‐mediated cell–cell compaction, enabling rapid assembly of high‐viability spheroids with defined size and morphology.
Han Gyeol Nam, Seon Yeong Chae, Young Woo Kwon, Hye Jin Heo, Hye Rin Lee, Ji Hyeok Lee, Dong‐Wook Han, Yun Hak Kim, Suck Won Hong   +8 more
wiley   +1 more source

Dermal Fibroblasts, Not Keratinocytes, Dominate IL-17A/TNF-Driven Inflammation. [PDF]

Exp Dermatol
Svraka L, Abdallah HB, Bertelsen T, Vestergaard C, Johansen C.   +4 more
europepmc   +1 more source