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Inflammasomes and Fibrosis [PDF]
Frontiers in Immunology, 2021 Fibrosis is the final common pathway of inflammatory diseases in various organs. The inflammasomes play an important role in the progression of fibrosis as innate immune receptors. There are four main members of the inflammasomes, such as NOD-like receptor protein 1 (NLRP1), NOD-like receptor protein 3 (NLRP3), NOD-like receptor C4 (NLRC4), and absent ...
Wen-Juan Zhang +5 more
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Association between noninvasive fibrosis markers and cardio-vascular organ damage among adults with hepatic steatosis [PDF]
, 2014 Evidence suggests that advanced fibrosis, as determined by the noninvasive NAFLD fibrosis score (NFS), is a predictor of cardiovascular mortality in individuals with ultrasonography-diagnosed NAFLD. Whether the severity of histology (i.e., fibrosis stage)
Fiorentino, Tv +5 more
core +14 more sources
Journal of Translational Medicine, 2023 We are delighted to announce the launch of Fibrosis a new section of the Journal of Translational Medicine with the purpose of gathering current high-quality research to better understand the process of normal tissue repair as well as the pathogenetic mechanisms responsible for the onset and progression of tissue fibrosis that leads to organ ...
Pernia Marin, Monica, Salvatore, Mary
openaire +4 more sources
American Journal of Respiratory and Critical Care Medicine, 2022 Background This American Thoracic Society, European Respiratory Society, Japanese Respiratory Society, and Asociación Latinoamericana de Tórax guideline updates prior idiopathic pulmonary fibrosis (IPF) guidelines and addresses the progression of ...
G. Raghu +40 more
semanticscholar +1 more source
Kidney fibrosis: from mechanisms to therapeutic medicines
Signal Transduction and Targeted Therapy, 2023 Chronic kidney disease (CKD) is estimated to affect 10–14% of global population. Kidney fibrosis, characterized by excessive extracellular matrix deposition leading to scarring, is a hallmark manifestation in different progressive CKD; However, at ...
Rong-shuang Huang, P. Fu, Liang Ma
semanticscholar +1 more source
International Journal of Molecular Sciences, 2023 Most chronic inflammatory illnesses include fibrosis as a pathogenic characteristic. Extracellular matrix (ECM) components build up in excess to cause fibrosis or scarring.
S. Antar +3 more
semanticscholar +1 more source
Targeting TGF-β signal transduction for fibrosis and cancer therapy
Molecular Cancer, 2022 Transforming growth factor β (TGF-β) has long been identified with its intensive involvement in early embryonic development and organogenesis, immune supervision, tissue repair, and adult homeostasis.
Dandan Peng +4 more
semanticscholar +1 more source
Journal of the American Medical Association (JAMA), 2022 Importance Ablation of persistent atrial fibrillation (AF) remains a challenge. Left atrial fibrosis plays an important role in the pathophysiology of AF and has been associated with poor procedural outcomes.
N. Marrouche +21 more
semanticscholar +1 more source
Targeting fibrosis: mechanisms and clinical trials
Signal Transduction and Targeted Therapy, 2022 Fibrosis is characterized by the excessive extracellular matrix deposition due to dysregulated wound and connective tissue repair response. Multiple organs can develop fibrosis, including the liver, kidney, heart, and lung.
Manyu Zhao +12 more
semanticscholar +1 more source
Modern Rheumatology, 2009 Adenosine is an endogenous autocoid that regulates a multitude of bodily functions. Its anti-inflammatory actions are well known to rheumatologists since it mediates many of the anti-inflammatory effects of a number of antirheumatic drugs such as methotrexate.
Bruce N. Cronstein, Edwin S. L. Chan
openaire +3 more sources