Results 1 to 10 of about 1,182,877 (363)

Association between noninvasive fibrosis markers and cardio-vascular organ damage among adults with hepatic steatosis [PDF]

, 2014
Evidence suggests that advanced fibrosis, as determined by the noninvasive NAFLD fibrosis score (NFS), is a predictor of cardiovascular mortality in individuals with ultrasonography-diagnosed NAFLD. Whether the severity of histology (i.e., fibrosis stage)
Fiorentino, Tv, Perticone, F, Perticone, M, Sciacqua, A, Sesti, G, Succurro, E   +5 more
core   +19 more sources

Inflammasomes and Fibrosis [PDF]

Frontiers in Immunology, 2021
Fibrosis is the final common pathway of inflammatory diseases in various organs. The inflammasomes play an important role in the progression of fibrosis as innate immune receptors. There are four main members of the inflammasomes, such as NOD-like receptor protein 1 (NLRP1), NOD-like receptor protein 3 (NLRP3), NOD-like receptor C4 (NLRC4), and absent ...
Wen-Juan Zhang, Wen-Juan Zhang, Shu-Juan Chen, Shun-Chang Zhou, Su-Zhen Wu, Hui Wang   +5 more
openaire   +4 more sources

What Is Most Suitable for Children With Cystic Fibrosis—The Relationship Between Spirometry, Oscillometry, and Multiple Breath Nitrogen Washout

Frontiers in Pediatrics, 2022
IntroductionIn cystic fibrosis (CF), pathological lung changes begin early in life. The technological progress currently gives many diagnostic possibilities. However, pulmonary function testing in children remains problematic.ObjectivesOur study aimed to
Magdalena Postek, Magdalena Postek, Katarzyna Walicka-Serzysko, Katarzyna Walicka-Serzysko, Justyna Milczewska, Justyna Milczewska, Dorota Sands, Dorota Sands   +7 more
doaj   +1 more source

Scedosporium species and Lomentospora prolificans in Italian cystic fibrosis patients: prevalence and distribution in seven centers using a selective medium

Microbiologia Medica, 2021
Background and aims. Scedosporium species and Lomentospora prolificans are the filamentous fungi isolated more frequently from the cystic fibrosis (CF) lower airways, after Aspergillus fumigatus. Previous studies showed that, in CF patients, Scedosporium
Lisa Cariani, Arianna Biffi, Davide Guarneri, Antonio Teri, Daniela Girelli, Chiara Vignati, Patrizia Morelli, Silvia Campana, Daniela Dolce, Vita Dora Iula, Maria Rosaria Catania, Natalia Cirilli, Sara Rapagnani, Martina Rossitto, Ersilia Vita Fiscarelli   +14 more
doaj   +1 more source

Establishing CREATE: lessons learned in setting up a training environment for early-career researchers in respiratory medicine

BMC Medical Education, 2022
Background The purpose of the National Health and Medical Research Council Centre of Research Excellence in Pulmonary Fibrosis (CRE-PF) is to improve and extend the lives of patients living with pulmonary fibrosis through the development of a ...
Katherine Christian, Alison Hey-Cunningham, Tamera Corte, Nicole Goh, Jade Jaffar, Paul Reynolds, Alan Teoh, Lauren Troy   +7 more
doaj   +1 more source

A small molecule high throughput screening platform to profile conformational properties of nascent, ribosome-bound proteins

Scientific Reports, 2022
Genetic mutations cause a wide spectrum of human disease by disrupting protein folding, both during and after synthesis. Transient de-novo folding intermediates therefore represent potential drug targets for pharmacological correction of protein folding ...
Hideki Shishido, Jae Seok Yoon, William R. Skach   +2 more
doaj   +1 more source

The Diagnosis of Cystic Fibrosis in Adult Age. Data from the Italian Registry

Diagnostics, 2021
Cystic Fibrosis (CF) registries are an essential resource of epidemiological and clinical data. Although the median age at diagnosis is usually reported in the first months of life, a minority of individuals is diagnosed during adulthood. The aim of this
Rita Padoan, Serena Quattrucci, Annalisa Amato, Vincenzo Carnovale, Donatello Salvatore, Marco Salvatore, Giuseppe Campagna   +6 more
doaj   +1 more source

Association between Polyunsaturated Fatty Acid Profile and Bronchial Inflammation in Bronchiolitis Obliterans

Mediators of Inflammation, 2023
Introduction. Bronchiolitis obliterans (BO) is a chronic lung disease, which occurs after an insult to the lower airways, in particular after airway infections or after stem cell transplantation, and which results in persistent inflammation.
Silvija P. Jerkic, Laura Bächle, Ruth Pia Duecker, Lucia Gronau, Andreas G. Chiocchetti, Stefan Zielen, Ralf Schubert   +6 more
doaj   +1 more source

Cystic fibrosis in Tuscany: evolution of newborn screening strategies over time to the present

Italian Journal of Pediatrics, 2021
Background Cystic fibrosis (CF) is a life-threatening disease affecting about 1:3000 newborns in Caucasian populations. The introduction of newborn screening for cystic fibrosis (CF NBS) has improved the clinical outcomes of individuals with CF through ...
Matteo Botti, Vito Terlizzi, Michela Francalanci, Daniela Dolce, Maria Chiara Cavicchi, Anna Silvia Neri, Valeria Galici, Gianfranco Mergni, Lucia Zavataro, Claudia Centrone, Filippo Festini, Giovanni Taccetti   +11 more
doaj   +1 more source

Collagenase Nanocapsules: An Approach to Fibrosis Treatment [PDF]

Acta Biomaterialia. 74, 430-438 (2018), 2021
Fibrosis is a common lesion in different pathologic diseases and is defined by the excessive accumulation of collagen. Different approaches have been used to treat different conditions characterized by fibrosis. FDA and EMA approved collagenase to treat palmar fibromatosis, Dupuyten disease. EMA approved additionally its use in severe Peyronie disease,
arxiv   +1 more source