Results 1 to 10 of about 168,475 (124)
Inflammasomes and Fibrosis [PDF]
Frontiers in Immunology, 2021 Fibrosis is the final common pathway of inflammatory diseases in various organs. The inflammasomes play an important role in the progression of fibrosis as innate immune receptors. There are four main members of the inflammasomes, such as NOD-like receptor protein 1 (NLRP1), NOD-like receptor protein 3 (NLRP3), NOD-like receptor C4 (NLRC4), and absent ...
Wen-Juan Zhang +5 more
openaire +4 more sources
Collagenase Nanocapsules: An Approach to Fibrosis Treatment [PDF]
Acta Biomaterialia. 74, 430-438 (2018), 2021 Fibrosis is a common lesion in different pathologic diseases and is defined by the excessive accumulation of collagen. Different approaches have been used to treat different conditions characterized by fibrosis. FDA and EMA approved collagenase to treat palmar fibromatosis, Dupuyten disease. EMA approved additionally its use in severe Peyronie disease,
arxiv +1 more source
Impact of noise on the instability of spiral waves in stochastic 2D mathematical models of human atrial fibrillation [PDF]
Journal of Biological Physics 49 (2023) 521-533, 2023 Sustained spiral waves, also known as rotors, are pivotal mechanisms in persistent atrial fibrillation (AF). Stochasticity is inevitable in nonlinear biological systems such as the heart; however, it is unclear how noise affects the instability of spiral waves in human AF.
arxiv +1 more source
, 2021 Fibrosis can occur in many tissues within the body, including skin, liver, lung, heart, intestine and pancreas. The wound healing response that replaces damaged tissue with non-functional collagen-rich scar tissue to maintain the physical boundaries of the affected organ, although necessary, can lead to a progressive irreversible fibrotic response, if ...
Distler, Oliver +2 more
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Retroperitoneal fibrosis [PDF]
The Lancet, 2006 Retroperitoneal fibrosis encompasses a range of diseases characterised by the presence of a fibro-inflammatory tissue, which usually surrounds the abdominal aorta and the iliac arteries and extends into the retroperitoneum to envelop neighbouring structures--eg, ureters. Retroperitoneal fibrosis is generally idiopathic, but can also be secondary to the
Vaglio, Augusto +2 more
openaire +5 more sources
Influence of portal vein occlusion on portal flow and liver elasticity in an animal model [PDF]
NMR in Biomedicine, Wiley, 2021, pp.e4498, 2021 Hepatic fibrosis causes an increase in liver stiffness, a parameter measured by elastography and widely used as a diagnosis method. The concomitant presence of portal vein thrombosis (PVT) implies a change in hepatic portal inflow that could also affect liver elasticity.
arxiv +1 more source
Modern Rheumatology, 2009 Adenosine is an endogenous autocoid that regulates a multitude of bodily functions. Its anti-inflammatory actions are well known to rheumatologists since it mediates many of the anti-inflammatory effects of a number of antirheumatic drugs such as methotrexate.
Bruce N. Cronstein, Edwin S. L. Chan
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Scraping fibrosis: Expressway to the core of fibrosis [PDF]
Nature Medicine, 2011 Animal experiments using single organs as models of fibrosis spur therapeutic development toward promising targets, but testing of these therapies in human fibrosis yielded disappointing results and limited efficacy. Finding core pathways relevant in different organs that can become fibrotic will uncover molecules that will prove useful as therapeutic ...
Scott L. Friedman +2 more
openaire +2 more sources
Arrhythmogenicity of cardiac fibrosis: fractal measures and Betti numbers [PDF]
arXiv, 2021 Infarction- or ischaemia-induced cardiac fibrosis can be arrythmogenic. We use mathematcal models for diffuse fibrosis ($\mathcal{DF}$), interstitial fibrosis ($\mathcal{IF}$), patchy fibrosis ($\mathcal{PF}$), and compact fibrosis ($\mathcal{CF}$) to study patterns of fibrotic cardiac tissue that have been generated by new mathematical algorithms.
arxiv
Detection of Fibrosis in Cine Magnetic Resonance Images Using Artificial Intelligence Techniques [PDF]
, 2022 Background: Artificial intelligence techniques have demonstrated great potential in cardiology, especially to detect imperceptible patterns for the human eye. In this sense, these techniques seem to be adequate to identify patterns in the myocardial texture which could lead to characterize and quantify fibrosis.
arxiv +1 more source