Increased Left Ventricular Mass Index and Atrial Volume Index Are Associated with Atrial Fibrosis in Patients with Atrial Fibrillation. [PDF]
Manole S+10 more
europepmc +1 more source
Management of Sclerosing Fibrosis of the Mediastinal and Retroperitoneal Areas
William P. Longmire+2 more
openalex +2 more sources
Osteoblast‐CD4+ CTL Crosstalk Mediated by SIRT1/DAAM2 Axis Prevents Age‐Related Bone Loss
In the osteoblastic niche, SIRT1 activates and recruits CD4+ CTLs by increasing DAAM2 expression via EZH2 deacetylation and boosting the secretion of key chemokines, such as CCL3, CCL5, and CXCL10. Then, CD4+ CTL directly eliminates senescent osteoblasts in an MHC‐II‐dependent way, thereby slowing down the process of bone ageing and effectively ...
Bin Yang+20 more
wiley +1 more source
Association of serum trace elements with non-invasive fibrosis scores in metabolic dysfunction-associated steatotic liver disease. [PDF]
Banisefid E+5 more
europepmc +1 more source
Methysergide and retroperitoneal fibrosis.
Reginald J. Carr, Bivas Biswas
openalex +1 more source
PRDM16 Reduces Cellular Senescence by Upregulating GSTM1
Cellular senescence drives aging and aging‐related organ disorders, yet PRDM16's role remains unexplored. This work uncovers that PRDM16 decreases significantly in aged organs, while its loss accelerates cellular senescence and aging‐related organ injury.
Qian Yuan+7 more
wiley +1 more source
Efficacy and safety of anti-obesity drugs in metabolic dysfunction-associated steatotic liver disease: An updated review. [PDF]
Concepción-Zavaleta MJ+9 more
europepmc +1 more source
Life Factors and Melanoma: From the Macroscopic State to the Molecular Mechanism
Melanoma, an aggressive skin cancer, arises from dynamic interactions between genetic, environmental, and lifestyle factors. This review explores how age, gender, obesity, diet, exercise, smoking, alcohol, UV exposure, circadian rhythms, and medications influence melanoma risk and progression.
Hanbin Wang+4 more
wiley +1 more source
Considerations and clinical utility of referral pathways for early detection of liver disease in at-risk populations. [PDF]
Pustjens J+4 more
europepmc +1 more source
Developmental Hypoxia Enhances Kidney Organoid Complexity and Maturity
The current bottleneck in metanephric mesenchyme (MM)‐derived nephron organoid development is the absence of a connected network of collecting ducts (CD) derived from the ureteric bud (UB). To address this limitation, this study proposes a hypoxia‐based differentiation method that mimics the natural renal developmental environment, enabling the ...
Hyeonji Lim+6 more
wiley +1 more source