Results 51 to 60 of about 1,754,298 (385)

Elevated sweat chloride test: is it always cystic fibrosis?

Italian Journal of Pediatrics, 2021
Background The sweat chloride test (ST) is the gold standard for cystic fibrosis (CF) diagnosis in symptomatic patients, within the newborn screening and in the follow-up of CF patients during molecular therapies.
C. Cimbalo, A. Tosco, V. Terlizzi, A. Sepe, A. Castaldo, L. Salvadori, V. Raia   +6 more
doaj   +1 more source

Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives

Cells, 2020
Liver fibrosis due to viral or metabolic chronic liver diseases is a major challenge of global health. Correlating with liver disease progression, fibrosis is a key factor for liver disease outcome and risk of hepatocellular carcinoma (HCC).
Natascha Roehlen, E. Crouchet, T. Baumert   +2 more
semanticscholar   +1 more source

Cystic Fibrosis Foundation and European Cystic Fibrosis Society Survey of cystic fibrosis mental health care delivery [PDF]

, 2015
Background: Psychological morbidity in individuals with cystic fibrosis (CF) and their caregivers is common. The Cystic Fibrosis Foundation (CFF) and European Cystic Fibrosis Society (ECFS) Guidelines Committee on Mental Health sought the views of CF ...
A.L. Quittner, A.M. Georgiopoulos, B.A. Smith, B.C. Marshall, Boyle, Braun, Clarke, DiMatteo, Fidika, Foy, Foy, Godfrey, Havermans, Health Disorders, J. Abbott, J.S. Elborn, K.A. Sabadosa, L. Goldbeck, Lewiston, Manfreda, Mitchell, Monkey, Moussavi, National Collaborating Centre For Mental Health (UK), National Collaborating Centre for Mental Health (UK), Nulty, Quittner, Riekert, Sawicki, Shih, Smith, Snell, Stern, West   +33 more
core   +1 more source

Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease.

Gastroenterology, 2015
BACKGROUND & AIMS Histologic analysis of liver biopsy specimens allows for grading and staging of nonalcoholic fatty liver disease (NAFLD). We performed a longitudinal study to investigate the long-term prognostic relevance of histologic features for ...
P. Angulo, D. Kleiner, S. Dam-Larsen, L. Adams, E. Bjornsson, P. Charatcharoenwitthaya, P. Mills, Jill C. Keach, H. Lafferty, Alisha Stahler, Svanhildur Haflidadottir, F. Bendtsen   +11 more
semanticscholar   +1 more source

Transforming growth factor–β in tissue fibrosis

Journal of Experimental Medicine, 2020
TGF-β is a central mediator in the fibrotic response. This review discusses the role of TGF-β in tissue fibrosis, highlighting the mechanisms of TGF-β activation and signaling, the cellular targets of TGF-β actions, and the challenges of therapeutic ...
N. Frangogiannis
semanticscholar   +1 more source

Fat in Fibrosis [PDF]

American Journal of Respiratory and Critical Care Medicine, 2013
To the Editor: Recent efforts in cellular reprogramming to repair injured organs have focused particularly on fibroblasts (1). As fibroblasts are key effector cells in the development of fibrosis, this seems a rational approach. However, we wonder whether, in addition to fibroblasts, the contribution of another cell type may be critical to ...
Cara J. Gottardi, Anna P. Lam
openaire   +3 more sources

Amelioration of bleomycin-induced lung fibrosis in hamsters by dietary supplementation with taurine and niacin: biochemical mechanisms. [PDF]

, 1994
Interstitial pulmonary fibrosis induced by intratracheal instillation of bleomycin (BL) involves an excess production of reactive oxygen species, unavailability of adequate levels of NAD and ATP to repair the injured pulmonary epithelium, and an ...
Chandler DB, Chien KR, Christner P, Clark JG, Counts DF, Crouch E, D M Hyde, Fukae M, Garnick MB, Giri SN, Giri SN, Karlinski JB, Kelley J, Koob TJ, Lowry OH, Marom Z, McQuaid A, Misra HP, Moss DW, Nakashima JM, Nakashima T, Phan SH, Q Wang, R B Rucker, R Blaisdell, Reiser KM, Riley DJ, S N Giri, Scherle WF, Snider GL, Thrall RS, Trush MA, Wang Q, Witschi HP, Zuckerman JE   +34 more
core   +2 more sources

Accuracy of FibroScan Controlled Attenuation Parameter and Liver Stiffness Measurement in Assessing Steatosis and Fibrosis in Patients With Nonalcoholic Fatty Liver Disease.

Gastroenterology, 2019
BACKGROUND & AIMS We estimated the accuracy of FibroScan vibration-controlled transient elastography controlled attenuation parameter (CAP) and liver stiffness measurement (LSMs) in assessing steatosis and fibrosis in patients with suspected nonalcoholic
P. Eddowes, M. Sasso, M. Allison, E. Tsochatzis, Q. Anstee, D. Sheridan, I. Guha, J. Cobbold, J. Deeks, V. Paradis, P. Bedossa, P. Newsome   +11 more
semanticscholar   +1 more source

Cystic fibrosis mice carrying the missense mutation G551D replicate human genotype phenotype correlations [PDF]

, 1996
We have generated a mouse carrying the human G551D mutation in the cystic fibrosis transmembrane conductance regulator gene (CFTR) by a one-step gene targeting procedure.
Alton, Ewfw, Delaney, S. J., Dorin, J. R., Farley, R., Hume, D. A., Lamb, D., Lovelock, P. K., Lunn, D. P., Porteous, D. J., Smith, S. N., Thomson, S. A., Wainwright, B. J.   +11 more
core   +2 more sources

Cardiac fibrosis.

Cardiovascular Research, 2020
Myocardial fibrosis, the expansion of the cardiac interstitium through deposition of extracellular matrix proteins, is a common pathophysiologic companion of many different myocardial conditions.
Nikolaos G Frangogiannis
semanticscholar   +1 more source