Results 51 to 60 of about 607,838 (295)

Transforming growth factor–β in tissue fibrosis

Journal of Experimental Medicine, 2020
TGF-β is a central mediator in the fibrotic response. This review discusses the role of TGF-β in tissue fibrosis, highlighting the mechanisms of TGF-β activation and signaling, the cellular targets of TGF-β actions, and the challenges of therapeutic ...
N. Frangogiannis
semanticscholar   +1 more source

Does cystic fibrosis constitute an advantage in COVID-19 infection?

Italian Journal of Pediatrics, 2020
The Veneto region is one of the most affected Italian regions by COVID-19. Chronic lung diseases, such as chronic obstructive pulmonary disease (COPD), may constitute a risk factor in COVID-19. Moreover, respiratory viruses were generally associated with
Valentino Bezzerri, Francesca Lucca, Sonia Volpi, Marco Cipolli   +3 more
doaj   +1 more source

Cardiac fibrosis.

Cardiovascular Research, 2020
Myocardial fibrosis, the expansion of the cardiac interstitium through deposition of extracellular matrix proteins, is a common pathophysiologic companion of many different myocardial conditions.
Nikolaos G Frangogiannis
semanticscholar   +1 more source

Six minute walk test in Italian children with cystic fibrosis aged 6 and 11

Monaldi Archives for Chest Disease, 2021
Six Minute Walk Test (6MWT) is a field exercise test widely used in clinical practice, both in adults and in pediatric patients. The primary aim of the study is to evaluate the physical performance of the subjects and compare them with the predicted ...
Diletta Innocenti, Eleonora Masi, Giovanni Taccetti, Marco Genito, Elena Balestri, Anna Rita Berghelli, Maria Antonietta Ciciretti, Francesca Collini, Patrizia Fanzaghi, Annalisa Fogazzi, Paola Leone, Riccardo Guarise   +11 more
doaj   +1 more source

Increased risk of mortality by fibrosis stage in nonalcoholic fatty liver disease: Systematic review and meta‐analysis

Hepatology, 2017
Liver fibrosis is the most important predictor of mortality in nonalcoholic fatty liver disease (NAFLD). Quantitative risk of mortality by fibrosis stage has not been systematically evaluated.
P. Dulai, Siddharth Singh, J. Patel, Meera Soni, L. Prokop, Z. Younossi, G. Sebastiani, M. Ekstedt, H. Hagstrom, P. Nasr, P. Stål, V. Wong, S. Kechagias, R. Hultcrantz, R. Loomba   +14 more
semanticscholar   +1 more source

Decoding myofibroblast origins in human kidney fibrosis

Nature, 2020
Kidney fibrosis is the hallmark of chronic kidney disease progression; however, at present no antifibrotic therapies exist 1 – 3 . The origin, functional heterogeneity and regulation of scar-forming cells that occur during human kidney fibrosis remain ...
C. Kuppe, Mahmoud M. Ibrahim, J. Kranz, Xiaoting Zhang, S. Ziegler, J. Perales-Patón, J. Jansen, Katharina C. Reimer, James R. Smith, R. Dobie, John R Wilson-Kanamari, Maurice Halder, Yaoxian Xu, Nazanin Kabgani, Nadine Kaesler, Martin Klaus, L. Gernhold, Victor G. Puelles, T. Huber, P. Boor, Sylvia Menzel, R. Hoogenboezem, E. Bindels, J. Steffens, J. Floege, R. Schneider, J. Saez-Rodriguez, N. Henderson, R. Kramann   +28 more
semanticscholar   +1 more source

Insights into the renal pathophysiology in Hermansky‐Pudlak syndrome‐1 from urinary extracellular vesicle proteomics and a new mouse model

FEBS Letters, EarlyView.
Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard, Bernadette R. Gochuico, Hadass Pri Chen, Christopher K. E. Bleck, Patricia M. Zerfas, Wendy J. Introne, William A. Gahl, May C. V. Malicdan   +7 more
wiley   +1 more source

A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion

Nature Communications, 2021
Premature termination codons can cause early translation termination and lead to disease. Here the authors perform a screen to identify compounds with readthrough activity and show that these reduce eRF1 levels to suppress premature termination ...
Jyoti Sharma, Ming Du, Eric Wong, Venkateshwar Mutyam, Yao Li, Jianguo Chen, Jamie Wangen, Kari Thrasher, Lianwu Fu, Ning Peng, Liping Tang, Kaimao Liu, Bini Mathew, Robert J. Bostwick, Corinne E. Augelli-Szafran, Hermann Bihler, Feng Liang, Jerome Mahiou, Josef Saltz, Andras Rab, Jeong Hong, Eric J. Sorscher, Eric M. Mendenhall, Candice J. Coppola, Kim M. Keeling, Rachel Green, Martin Mense, Mark J. Suto, Steven M. Rowe, David M. Bedwell   +29 more
doaj   +1 more source

Fat in Fibrosis [PDF]

American Journal of Respiratory and Critical Care Medicine, 2013
To the Editor: Recent efforts in cellular reprogramming to repair injured organs have focused particularly on fibroblasts (1). As fibroblasts are key effector cells in the development of fibrosis, this seems a rational approach. However, we wonder whether, in addition to fibroblasts, the contribution of another cell type may be critical to ...
Cara J. Gottardi, Anna P. Lam
openaire   +3 more sources

Bariatric Surgery Provides Long-term Resolution of Nonalcoholic Steatohepatitis and Regression of Fibrosis.

Gastroenterology, 2020
BACKGROUND & AIMS Studies are needed to determine the long-term effects of bariatric surgery for patients with nonalcoholic steatohepatitis (NASH). We evaluated sequential liver biopsies, collected the time of bariatric surgery and 1 and 5 years later ...
G. Lassailly, R. Caiazzo, Line-Carolle Ntandja-Wandji, V. Gnemmi, G. Baud, Hélène Verkindt, Massih Ningarhari, A. Louvet, E. Leteurtre, V. Raverdy, S. Dharancy, F. Pattou, P. Mathurin   +12 more
semanticscholar   +1 more source