Results 101 to 110 of about 7,998 (276)

Complement activation and its prognostic role in post-cardiac arrest patients [PDF]

, 2014
Cardiac arrest causes generalized ischemia/hypoxia, and subsequent resuscitation inflicts reperfusion injury, the pathology of which is not fully understood.
Bisschops, Bottiger, Cervera, Dunkelberger, Fust, Gombos, Gorsuch, Kohler, Lindsberg, Matsushita, Mocco, Oddo, Pedersen, Prohaszka, Shinozaki, Szeplaki, Turner, Wojtczak-Soska   +17 more
core   +1 more source

The Role of Ficolins in Innate Immunity

Immunobiology, 2002
Ficolins are a group of proteins containing both a collagen-like domain and a fibrinogen-like domain and are found in varying tissues. Ficolins present in sera have a lectin activity toward N-acetylglucosamine through their fibrinogen-like domains. The domain organizations between ficolins and mannose-binding lectin (MBL) are very similar in that both ...
Misao Matsushita, Teizo Fujita
openaire   +3 more sources

Genome of Kumamoto Oyster Crassostrea sikamea Provides Insights Into Bivalve Evolution and Environmental Adaptation

Evolutionary Applications, Volume 18, Issue 4, April 2025.
ABSTRACT The Kumamoto oyster, Crassostrea sikamea, is a marine bivalve naturally distributed along the coasts of southern China and southern Japan, with a hatchery population that has been under domestication in the United States since its introduction from Japan in the 1940s.
Sheng Liu, Youli Liu, Ximing Guo, Naoki Itoh, Guangqiu Chang, Zhihua Lin, Qinggang Xue   +6 more
wiley   +1 more source

Multiple roles of complement MASP-1 at the interface of innate immune response and coagulation [PDF]

, 2014
MASP-1 is a versatile serine protease that cleaves a number of substrates in human blood. In recent years it became evident that besides playing a crucial role in complement activation MASP-1 also triggers other cascade systems and even cells to mount a ...
Adams, Amara, Ambrus, Bode, Chen, Dahl, Degn, Degn, Distelmaier, Dobó, Dobó, Duehrkop, Endo, Endo, Feinberg, Frauenknecht, Frauenknecht, Gaboriaud, Gaboriaud, Gingras, Gregory, Gulla, Gál, Gál, Henriksen, Hess, Hess, Howes, Huber-Lang, Héja, Héja, Iwaki, Jani, Jenny, József Dobó, Kawanami, Kidmose, Kjaer, Kocsis, Krarup, Krarup, Krisinger, La Bonte, Lorenz Jenny, László Cervenak, Marin, Markiewski, Matsushita, Matsushita, Matsushita, Megyeri, Megyeri, Megyeri, Mellbin, Møller-Kristensen, Oikonomopoulou, Oksjoki, Oroszlán, Paréj, Paréj, Presanis, Péter Gál, Péter Závodszky, Richardson, Rooryck, Rosbjerg, Schiffmann, Schroeder, Shats-Tseytlina, Sirmaci, Skjoedt, Speidl, Takahashi, Takahashi, Teillet, Thiel, Thiel, Undas, Verena Schroeder, Vorup-Jensen, Yongqing, Zhang, Zotter   +82 more
core   +1 more source

LncRNA AK036396 Inhibits Maturation and Accelerates Immunosuppression of Polymorphonuclear Myeloid–Derived Suppressor Cells by Enhancing the Stability of Ficolin B

Cancer immunology research, 2020
Knockdown of a lncRNA or its target, ficolin B, inhibits the immunosuppressive capacity of PMN-MDSCs and delays tumor progression in mice. M-ficolin, the human ortholog of ficolin B, is elevated in patients with lung cancer, suggesting clinical relevance.
Xinyu Tian, Y. Zheng, Kai Yin, Jie Ma, Jie Tian, Yue Zhang, Lingxiang Mao, Huaxi Xu, Shengjun Wang   +8 more
semanticscholar   +1 more source

Ficolins do not alter host immune responses to lipopolysaccharide-induced inflammation in vivo

Scientific Reports, 2017
Ficolins are a family of pattern recognition molecules that are capable of activating the lectin pathway of complement. A limited number of reports have demonstrated a protective role of ficolins in animal models of infection.
Ninette Genster, Olga Østrup, Camilla Schjalm, Tom Eirik Mollnes, Jack B. Cowland, Peter Garred   +5 more
doaj   +1 more source

The Lectin Complement Pathway Is Involved in Protection Against Enteroaggregative Escherichia coli Infection

Frontiers in Immunology, 2018
Enteroaggregative Escherichia coli (EAEC) causes acute and persistent diarrhea worldwide. Still, the involvement of host factors in EAEC infections is unresolved. Binding of recognition molecules from the lectin pathway of complement to EAEC strains have
Camilla Adler Sørensen, Camilla Adler Sørensen, Anne Rosbjerg, Betina Hebbelstrup Jensen, Karen Angeliki Krogfelt, Peter Garred   +5 more
doaj   +1 more source

Plasma proteomic profiles correlate with organ dysfunction in COVID‐19 ARDS

Physiological Reports, Volume 13, Issue 7, April 2025.
Abstract Severe COVID‐19 is often complicated by hypoxemic respiratory failure and acute respiratory distress syndrome (ARDS). Mechanisms governing lung injury and repair in ARDS remain poorly understood. We hypothesized that plasma proteomics may uncover protein biomarkers correlated with COVID‐19 ARDS severity. We analyzed the plasma proteome from 32
Moemen Eltobgy, Brett Klamer, Daniela Farkas, James D. Londino, Joshua A. Englert, Jeffrey C. Horowitz, Rama K. Mallampalli, Guy Brock, Joseph S. Bednash   +8 more
wiley   +1 more source

Genetic variants of innate immune receptors and infections after liver transplantation. [PDF]

, 2017
Infection is the leading cause of complication after liver transplantation, causing morbidity and mortality in the first months after surgery. Allograft rejection is mediated through adaptive immunological responses, and thus immunosuppressive therapy is
Cervera, Carlos, Lozano Soto, Francisco, Moreno Camacho, Ma. Asunción, Navasa, Miquel, Sanclemente, Gemma   +4 more
core   +1 more source

Association of L-ficolin levels and FCN2 genotypes with chronic Chagas disease.

PLoS ONE, 2013
BackgroundL-ficolin (encoded by FCN2) binds to acetylated sugar moieties of many pathogens, including Trypanosoma cruzi, promoting their phagocytosis and lysis by the complement system.MethodsWe investigated L-ficolin levels in 160 T.
Paola R Luz, Angelica B W Boldt, Caroline Grisbach, Jürgen F J Kun, Thirumalaisamy P Velavan, Iara J T Messias-Reason   +5 more
doaj   +1 more source