, 2017 Introduction IgA nephropathy (IgAN) is characterized by glomerular deposition of galactose-deficient IgA1 and complement proteins and leads to renal impairment.
Constantinou, N +9 more
core +2 more sources
Complement activation and protein adsorption by carbon nanotubes [PDF]
, 2006 As a first step to validate the use of carbon nanotubes as novel vaccine or drug delivery devices, their interaction with a part of the human immune system, complement, has been explored.
Flahaut, Emmanuel +5 more
core +2 more sources
Does native Trypanosoma cruzi calreticulin mediate growth inhibition of a mammary tumor during infection? [PDF]
, 2016 Indexación: Web of Science.Background: For several decades now an antagonism between Trypanosoma cruzi infection and tumor development has been detected. The molecular basis of this phenomenon remained basically unknown until our proposal that T.
A Colombo +42 more
core +1 more source
Differential Role of the Lectin Pathway of Complement Activation in Susceptibility to Neonatal Sepsis [PDF]
, 2017 Background. The incidence of bacterial sepsis during the neonatal period is high. Mannan-binding lectin (MBL), L-ficolin, and H-ficolin recognize microorganisms and activate the complement system viaMBL-associated serine proteases (MASPs).
Boillat, Colette +8 more
core
Extensive Basal Level Activation of Complement Mannose-Binding Lectin-Associated Serine Protease-3: Kinetic Modeling of Lectin Pathway Activation Provides Possible Mechanism [PDF]
, 2017 Serine proteases (SPs) are typically synthesized as precursors, termed proenzymes or zymogens, and the fully active form is produced via limited proteolysis by another protease or by autoactivation.
Dani, Ráhel +6 more
core +2 more sources
Dectin-2 recognises mannosylated O-antigens of human opportunistic pathogens and augments lipopolysaccharide activation of myeloid cells [PDF]
, 2016 Lipopolysaccharide (LPS) consists of a relatively conserved region of lipid A and core-oligosaccharide, and a highly variable region of O-antigen polysaccharide.
Akatsuka +82 more
core +1 more source
Ficolin B in Diabetic Kidney Disease in a Mouse Model of Type 1 Diabetes
Mediators of Inflammation, 2015 Background. The innate immune system may have adverse effects in diabetes and cardiovascular disease. The complement system seems to play a key role through erroneous complement activation via hyperglycaemia-induced neoepitopes.
Charlotte Berg Holt +6 more
doaj +1 more source
Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation [PDF]
, 2015 MFAP4 (microfibrillar-associated protein 4) is an extracellular glycoprotein found in elastic fibers without a clearly defined role in elastic fiber assembly.
Heumüller, Stefanie E +11 more
core +1 more source
Monte Carlo analysis of an ODE Model of the Sea Urchin Endomesoderm Network [PDF]
, 2009 Gene Regulatory Networks (GRNs) control the differentiation, specification and function of cells at the genomic level. The levels of interactions within large GRNs are of enormous depth and complexity.
Clemens Kühn +6 more
core +2 more sources
PLoS ONE, 2013 BackgroundIn HIV-infected patients, prediction of Cytomegalovirus (CMV) disease remains difficult. A protective role of mannan-binding lectin (MBL) and ficolins against CMV disease has been reported after transplantation, but the impact in HIV-infected ...
Adrian Egli +12 more
doaj +1 more source