Results 121 to 130 of about 7,998 (276)

Exosomal‐complement system activation in preeclampsia

Journal of Obstetrics and Gynaecology Research, Volume 51, Issue 3, March 2025.
Abstract Aim Preeclampsia (PE) is a severe pregnancy‐related disorder characterized by hypertension and multi‐organ failure, primarily affecting the maternal vasculature and placenta. The aim of this review is to explain the molecular mechanisms behind PE by investigating the relationship between exosome release and complement activation, which could ...
M. David, N. Maharaj, A. Krishnan
wiley   +1 more source

Multiple Infectious Complications in a Severely Injured Patient with Single Nucleotide Polymorphisms in Important Innate Immune Response Genes [PDF]

, 2015
Trauma is a major public health problem worldwide. Infectious complications, sepsis, and multiple organ dysfunction syndrome (MODS) remain important causes for morbidity and mortality in patients who survive the initial trauma.
Bronkhorst, M.W.G.A. (Maarten), Lieshout, E.M.M. (Esther) van, Patka, P. (Peter)   +2 more
core   +2 more sources

Association of FCN2 polymorphisms and Ficolin-2 levels with dengue fever in Vietnamese patients

International Journal of Infectious Diseases, 2020
Background and objective: The human ficolin-2, encoded by FCN2, recognizes pathogen-associated acetylated residues on their cell surfaces and activates the lectin complement cascade. This study aimed to investigate the contribution of human ficolin-2 and
Ngo Truong Giang, Hoang Van Tong, Trinh Huu Nghia, Hoang Vu Hung, Do Tuan Anh, Le Van Nam, Can Van Mao, Nguyen Truong Giang, Le Dinh Thanh, Ho Anh Son, Thirumalaisamy P. Velavan, Quyet Do, Nguyen Linh Toan   +12 more
doaj  

APOE genotype and brain amyloid are associated with changes in the plasma proteome in elderly subjects without dementia

Annals of Clinical and Translational Neurology, Volume 12, Issue 2, Page 366-382, February 2025.
Abstract Objective Recent work has bolstered the possibility that peripheral changes may be relevant to Alzheimer's disease pathogenesis in the brain. While age‐associated blood‐borne proteins have been targeted to restore function to the aged brain, it remains unclear whether other dysfunctional systemic states can be exploited for similar benefits ...
Sarah M. Philippi, Kailash BP, Towfique Raj, Joseph M. Castellano   +3 more
wiley   +1 more source

Human Inborn Errors of Immunity: 2019 Update of the IUIS Phenotypical Classification. [PDF]

, 2020
Since 2013, the International Union of Immunological Societies (IUIS) expert committee (EC) on Inborn Errors of Immunity (IEI) has published an updated phenotypic classification of IEI, which accompanies and complements their genotypic classification ...
Ailal, Fatima, Al-Herz, Waleed, Bousfiha, Aziz, Casanova, Jean-Laurent, Chatila, Talal, Cunningham-Rundles, Charlotte, Etzioni, Amos, Franco, Jose Luis, Holland, Steven M, Jeddane, Leila, Klein, Christoph, Morio, Tomohiro, Ochs, Hans D, Oksenhendler, Eric, Picard, Capucine, Puck, Jennifer, Sullivan, Kathleen E, Tangye, Stuart G, Torgerson, Troy R   +18 more
core  

Platelet–Monocyte Aggregate Instigates Inflammation and Vasculopathy in Kawasaki Disease

Advanced Science, Volume 12, Issue 5, February 3, 2025.
The formation of monocyte–platelet aggregate (MPA) induces the phenotypic conversion of monocytes into proinflammatory monocytes via the platelet release of transforming growth factor (TGF)β1, resulting in inflammation (interleukin‐1β, tissue necrotic factor‐α) and vasculopathy in Kawasaki disease (KD). Blocking MPA formation or reducing platelet TGFβ1
Yuan Zhang, Cuiping Jia, Manli Guo, Qian Chen, Ying Wen, Ting Wang, Yinyin Xie, Xuejiao Fan, Jingwen Gao, Timur O. Yarovinsky, Renjing Liu, Zhiyong Jiang, Mengmeng Wang, Jin Zhou, Di Che, Lanyan Fu, Richard Edelson, Xiaoqiong Gu, John Hwa, Wai Ho Tang   +19 more
wiley   +1 more source

Identification of CSPG4 as a Biomarker and Therapeutic Target for Infantile Post‐Hemorrhagic Hydrocephalus via Multi‐Omics Analysis

Advanced Science, Volume 12, Issue 6, February 10, 2025.
This study demonstrates that over‐representation of ferroptosis, calcium, calcium ion binding, and cell adhesion signaling pathways in cerebrospinal fluid is associated with infantile post‐hemorrhagic hydrocephalus (PHH). Importantly, the expression level of CSPG4 is correlated with PHH progression; and CSPG4 silencing suppresses the dysregulation of ...
Juncao Chen, Lin Wang, Xiangwen Peng, Tingting Cheng, Yihui Yang, Jingzhen Su, Hongmei Zou, Siyao Wang, Yueting Mao, Lixiang Wu, Xuntao Yin, Minxu Li, Mingwei Zhu, Wei Zhou   +13 more
wiley   +1 more source

Role of Myeloid-Derived Suppressor Cells in tumor-associated pregnancy [PDF]

, 2012
Cancer progression is dependent, in part, on interactions between tumor cells and the host microenvironment. During pregnancy, physiological changes occur that include inflammation and reduced immunity, both of which can promote tumor growth. Accordingly,
Waeber, S.
core  

GALDIERO is CO-FIRST AUTHOR. Phagocytes as Corrupted Policemen in Cancer-Related Inflammation [PDF]

, 2015
Inflammation is a key component of the tumor microenvironment. Tumor-associated macrophages (TAMs) and tumor-associated neutrophils (TANs) are prototypic inflammatory cells in cancer-related inflammation.
Bonavita, Eduardo, Galdiero, MARIA ROSARIA, Jaillon, Sebastien, Mantovani, Alberto   +3 more
core   +1 more source

Specific binding of L-ficolin and H-ficolin to apoptotic cells leads to complement activation

Immunobiology, 2005
The serum lectins mannose-binding lectin (MBL), L-ficolin, and H-ficolin are recognition molecules in the lectin complement pathway, which play an important role in innate immunity. To assess involvement of the lectin pathway in the clearance of apoptotic cells, we used flow cytometry to quantify binding of MBL, L-ficolin, and H-ficolin to apoptotic ...
Mikio Kuraya, Misao Matsushita, Teizo Fujita, Zhenping Ming, Xianzhou Liu   +4 more
openaire   +3 more sources