Results 101 to 110 of about 21,702 (299)
Association of Gene Variations POMP, FLG, MTOR and ATG5 gene with the Risk of Asthma in Children
Zdorovʹe Rebenka, 2016 The aim of this study was to determine the correlation between single-nucleotide polymorphisms in the proteasome maturation protein gene (POMP), filaggrin gene (FLG), mammalian target of rapamycin gene (MTOR) and autophagy gene (ATG5) and the development
O.P. Volosovets +5 more
doaj +1 more source
Clinical presentation of atopic dermatitis by filaggrin gene mutation status during the first 7 years of life in a prospective cohort study. [PDF]
PLoS ONE, 2012 BackgroundFilaggrin null mutations result in impaired skin barrier functions, increase the risk of early onset atopic dermatitis and lead to a more severe and chronic disease.
Charlotte Giwercman Carson +4 more
doaj +1 more source
Filaggrin: An Emerging Star in Atopic March
Journal of the Formosan Medical Association, 2008 429 Atopic dermatitis (AD) is a common chronic inflammatory skin disease characterized by itching and inflamed skin, showing from infancy and early childhood.1 It affects up to 20% of children with increasing prevalence in highly industrialized countries.1 Until recently, most pathophysiological concepts of AD have been attributed to immune system ...
Hiroshi Shimizu +2 more
openaire +3 more sources
Allergy, EarlyView.This study investigated the immune mechanisms underlying allergic contact dermatitis (ACD) in response to four distinct allergens by using RNA sequencing in a cohort of 40 non‐atopic patients and 19 controls. A shared ACD imprinting across allergens showed strong innate and adaptive responses, dominated by type 1 immunity but with mixed immune ...
David Pesqué +9 more
wiley +1 more source
Pharmaceutics, 2020 This study aimed to restore the skin barrier function from atopic dermatitis (AD) via treatment with leucine-rich glioma inactivated 3 (LGI3) peptide. Male NC/Nga mice (7 weeks, 20 g) were randomly allocated into three groups (control, AD, and LGI3 group)
Ui Seok Kim +8 more
doaj +1 more source
British Journal of Pharmacology, EarlyView.Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi +10 more
wiley +1 more source
A minimally invasive tool to study immune response and skin barrier in children with atopic dermatitis [PDF]
, 2019 Background: Atopic dermatitis (AD) affects children of all skin types. Most research has focused on light skin types. Studies investigating biomarkers in people with AD with dark skin types are lacking.
Dontje, B. +11 more
core +7 more sources
Clinical Genetics, EarlyView.In 325 exomes of South Brazilian Mennonites, we identified 23 pathogenic variants (P) and 27 likely P, with founder effects identified for 96% of P, whose frequencies differed from non‐Finnish Europeans, Amish, and Brazilian populations. ABSTRACT The Mennonite population has a unique history of 500 years of genetic isolation shaped by at least three ...
Luiza Beatriz Mayer de Lima +8 more
wiley +1 more source
A 66‐Year‐old Woman With Submammary Brownish Hyperkeratotic Plaques
JEADV Clinical Practice, EarlyView.
Antonia Kössinger +2 more
wiley +1 more source