Results 31 to 40 of about 17,078 (216)

Citrullination – small change with a great consequence [PDF]

, 2013
Citrullination is one of the possible post-translational modifications of proteins. It is based on a conversion of L-arginine residue (L-Arg) to L-citrulline residue (L-Cit). The reaction is catalyzed by peptidylarginine deiminases (PAD). The change of L-
Gogól Mariusz
core   +2 more sources

Atopic Dermatitis Host and Environment Model: Revisiting Therapeutic Options [PDF]

, 2020
Atopic Dermatitis affects both children and adults and is a serious health concern in many countries. AD is a complex disease with host and environmental factors underlying its pathology. Its treatment is multidimensional reflecting the diverse nature of
Abreu, C, Lopes, A, Lopes, C, Sokolova, A   +3 more
core   +1 more source

New Functions of Low-Molecular-Weight Hyaluronic Acid on Epidermis Filaggrin Production and Degradation

Cosmetics, 2021
Hyaluronic acid (HA) is a high-molecular-weight polysaccharide with high moisturizing power. It is composed of repeating disaccharides of N-acetyl-D-glucosamine and D-glucuronic acid.
Moe Hashimoto, Kazuhisa Maeda
doaj   +1 more source

A possible association between a dysfunctional skin barrier (filaggrin null-mutation status) and diabetes: a cross-sectional study

BMJ Open, 2011
Background Filaggrin proteins are located in the skin and prevent epidermal water loss and impede the entry of micro-organisms, allergens and chemicals.
Allan Linneberg, Torben Hansen, Jacob P Thyssen, Steen Stender, Oluf Pedersen, Berit C Carlsen, Jeanne D Johansen, Kåre Engkilde, Flemming Pociot, Michael Meldgaard, Pal B Szecsi, Torkil Menné   +11 more
doaj   +1 more source

Profile of clindamycin phosphate 1.2%/benzoyl peroxide 3.75% aqueous gel for the treatment of acne vulgaris. [PDF]

, 2015
Acne vulgaris is a common and chronic skin disease, and is a frequent source of morbidity for affected patients. Treatment of acne vulgaris is often difficult due to the multifactorial nature of this disease.
Eichenfield, Lawrence F, Nguyen, Tuyet A
core   +2 more sources

Studies Using Antibodies against Filaggrin and Filaggrin 2 in Canine Normal and Atopic Skin Biopsies

Animals
Filaggrin is important for the skin barrier and atopic dermatitis. Another filaggrin-like protein, filaggrin 2, has been described. We evaluated antibodies against both filaggrins in normal and atopic skin biopsies from dogs before and after allergen ...
Rosanna Marsella, Kim Ahrens, Rachel Wilkes   +2 more
doaj   +1 more source

Role of Filaggrin in Pediatric Allergology

Zdorovʹe Rebenka, 2013
There had been found strong evidence that a violation of the epidermal barrier is a necessary condition for the development of sensitivity to allergens.
A.P. Volosovets, S.P. Krivopustov, Ye.V. Pavlik   +2 more
doaj   +1 more source

Early-life regional and temporal variation in filaggrin-derived natural moisturizing factor, filaggrin-processing enzyme activity, corneocyte phenotypes and plasmin activity:Implications for atopic dermatitis [PDF]

, 2018
Background: Filaggrin is central to the pathogenesis of atopic dermatitis (AD). The cheeks are a common initiation site of infantile AD. Regional and temporal expression of levels of filaggrin degradation products [natural moisturizing factors (NMFs ...
Barrett, Bartnikas, Breternitz, Brough, Brown, Carson, Chittock, Clements, Dapic, DeLapp, Fallon, Fluhr, Gibbs, Halkjaer, Hoath, Horimukai, Hsu, Irvine, Kamata, Kamata, Kashibuchi, Kelleher, Kennedy, Kuroda, Ludriksone, McAleer, Mohammed, Mohammed, Raj, Raj, Rawlings, Sandilands, Sandilands, Schwartz, Scott, Simpson, Stamatas, Stamatas, Strid, Strid, Tagami, Takahashi, Takeda, Takeda, Visscher, Voegeli, Voegeli, Weidinger, Yamamoto, Yamazaki   +49 more
core   +3 more sources

Real-time PCR quantification of the canine filaggrin orthologue in the skin of atopic and non-atopic dogs: a pilot study

BMC Research Notes, 2011
Background Canine atopic dermatitis (AD) is a common inflammatory skin disease associated with defects in the epidermal barrier, particularly in West Highland white terriers (WHWTs).
Roque Joana, O'Leary Caroline A, Kyaw-Tanner Myat, Duffy David L, Shipstone Michael   +4 more
doaj   +1 more source

In silico analysis of the profilaggrin sequence indicates alterations in the stability, degradation route, and intracellular protein fate in filaggrin null mutation carriers

Frontiers in Molecular Biosciences, 2023
Background: Loss of function mutation in FLG is the major genetic risk factor for atopic dermatitis (AD) and other allergic manifestations. Presently, little is known about the cellular turnover and stability of profilaggrin, the protein encoded by FLG ...
Argho Aninda Paul, Natalia A. Szulc, Adrian Kobiela, Sara J. Brown, Wojciech Pokrzywa, Danuta Gutowska-Owsiak   +5 more
doaj   +1 more source