Autophagy generates citrullinated peptides in human synoviocytes: a possible trigger for anti-citrullinated peptide antibodies [PDF]
, 2016 OBJECTIVES: Autophagy may represent a functional processing event that creates a substrate for autoreactivity. In particular, autophagy may play a role in the pathogenesis of RA, since autophagy is a key cellular event involved in the generation of ...
Alessandra Nerviani +14 more
core +1 more source
Correlation of age-of-onset of Atopic Dermatitis with Filaggrin loss-of-function variant status
Scientific Reports, 2020 The genetic background of Atopic Dermatitis (AD) with chronic pruritus is complex. Filaggrin (FLG) is an essential gene in the epidermal barrier formation s.
S. Smieszek +6 more
semanticscholar +1 more source
Increased Production of IL-17A-Producing γδ T Cells in the Thymus of Filaggrin-Deficient Mice
Frontiers in Immunology, 2018 Mutations in the filaggrin gene (Flg) are associated with increased systemic levels of Th17 cells and increased IL-17A production following antigen exposure in both humans and mice. In addition to Th17 cells, γδ T cells can produce IL-17A.
Mia Hamilton Jee +12 more
doaj +1 more source
Recombinant Filaggrin Is Internalized and Processed to Correct Filaggrin Deficiency [PDF]
Journal of Investigative Dermatology, 2014 This study was designed to engineer a functional filaggrin (FLG) monomer linked to a cell-penetrating peptide (RMR) and to test the ability of this peptide to penetrate epidermal tissue as a therapeutic strategy for genetically determined atopic dermatitis (AD). A single repeat of the murine filaggrin gene (Flg) was covalently linked to a RMR motif and
Stout, Thomas E. +4 more
openaire +2 more sources
A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis [PDF]
, 2016 BACKGROUND: Filaggrin, encoded by the FLG gene, is an important component of the skin’s barrier to the external environment and genetic defects in FLG strongly associate with Atopic Dermatitis (AD).
Brown, S +7 more
core +7 more sources
Role of genetic aspect in pathogenesis of atopic dermatitis [PDF]
, 2013 The pathogenesis of atopic dermatitis (AD) is a very complicated process that involves an intricate array of molecules. Nowadays it is generally accepted that cytokines play an important role in the progression of the clinical presentation of atopic ...
Wesserling Martyna
core +1 more source
Clinical and Experimental Allergy, 2021 Atopic dermatitis (AD) is a common inflammatory skin disease among children with increasing prevalence in the past decades. The strongest and most widely replicated genetic risk factor for AD is a null mutation in the filaggrin gene (FLG) located on ...
Minke M. F. Mierlo +8 more
semanticscholar +1 more source
Loss-of-function variants of the filaggrin gene are associated with atopic eczema and associated phenotypes in Swedish families [PDF]
, 2008 Recent studies have identified 2 loss-of-function variants, R501X and 2282del4, in the filaggrin gene as predisposing factors in the development of eczema.
Bradley, Maria +7 more
core +3 more sources
Scientific Reports, 2022 Respiratory viral infections (RVIs) are frequent in preterm infants possibly inducing long-term impact on respiratory morbidity. Immune response and respiratory barriers are key defense elements against viral insults in premature infants admitted to ...
José M. Rodrigo-Muñoz +12 more
doaj +1 more source
Filaggrin Defect at Atopic Dermatitis: Modern Treatment Options
Вопросы современной педиатрии, 2022 Atopic dermatitis is a common chronic skin disease, its pathogenesis is associated with congenital or acquired deficiency of filaggrin protein. In recent years, extensive evidence on the causes of filaggrin deficiency has been obtained. The structure and
Nikolay N. Murashkin +8 more
doaj +1 more source