Loss of ceramide synthase 3 causes lethal skin barrier disruption [PDF]
, 2017 The stratum corneum as the outermost epidermal layer protects against exsiccation and infection. Both the underlying cornified envelope (CE) and the intercellular lipid matrix contribute essentially to these two main protective barriers. Epidermis-unique
Bayerle, Aline +14 more
core
Filaggrin null mutations are associated with atopic dermatitis and elevated levels of IgE in the Japanese population: a family and case–control study [PDF]
, 2008 Filaggrin (FLG) plays an important role in the barrier function of the skin. Several loss-of-function mutations in the FLG gene have been identified in patients with ichthyosis vulgaris, and these null mutations are associated with atopic dermatitis (AD)
Arinami Tadao +14 more
core +1 more source
Molecular mechanisms in atopic eczema:insight gained from genetic studies [PDF]
, 2017 Atopic eczema (synonymous with atopic dermatitis and eczema) is a common heterogeneous phenotype with a wide spectrum of severity from mild transient disease to a severe chronic disorder with atopic and non-atopic co-morbidities.
Adoue +64 more
core +2 more sources
Dr. Jekyll and Mr. Hyde: MAP17’s up-regulation, a crosspoint in cancer and inflammatory diseases [PDF]
, 2018 Inflammation is a common defensive response that is activated after different harmful stimuli. This chronic, or pathological, inflammation is also one of the causes of neoplastic transformation and cancer development. MAP17 is a small protein localized
Carnero Moya, Amancio +1 more
core +1 more source
Filaggrin failure - from ichthyosis vulgaris to atopic eczema and beyond [PDF]
, 2016 The main proteinaceous component of the keratohyalin granules within the granular layer keratinocytes of the epidermis is the giant, repetitive polyprotein profilaggrin.
Brown +13 more
core +2 more sources
Filaggrin‐2 barrier protein inversely varies with skin inflammation [PDF]
Experimental Dermatology, 2015 John, Seykora +2 more
openaire +2 more sources
Interplay of Staphylococcal and Host Proteases Promotes Skin Barrier Disruption in Netherton Syndrome. [PDF]
, 2020 Netherton syndrome (NS) is a monogenic skin disease resulting from loss of function of lymphoepithelial Kazal-type-related protease inhibitor (LEKTI-1).
Butcher, Anna M +12 more
core
Intractable & Rare Diseases Research, 2018 Bronchial asthma (BA), atopic dermatitis (AD), and allergic rhinitis (AR) are well known atopic disorders with complex etiologies. This study was undertaken to investigate the role of filaggrin, eosinophil major basic protein (MBP) and leukotriene B4 (LTB4) in patients with BA, AD, and AR.
Ghada, A +9 more
openaire +3 more sources
Atopic dermatitis: a mini review on pathology and treatment modalities [PDF]
Exploration of Asthma & AllergyThe symptoms of atopic dermatitis (AD), a chronic, recurrent inflammatory skin condition, include immunological dysregulation, severe pruritus, and malfunctioning of the epidermal barrier.
Amrita Sahu +2 more
doaj +1 more source
Quantitative Proteomic Profiling of Low-Dose Ionizing Radiation Effects in a Human Skin Model
Proteomes, 2014 To assess responses to low-dose ionizing radiation (LD-IR) exposures potentially encountered during medical diagnostic procedures, nuclear accidents or terrorist acts, a quantitative proteomic approach was used to identify changes in protein abundance ...
Shawna M. Hengel +4 more
doaj +1 more source