Results 181 to 190 of about 11,223 (224)

Characterization of a phosphorylated form of the intermediate filament-aggregating protein filaggrin

Biochemistry, 1982
Filaggrin and a phosphorylated form of filaggrin, which has been shown by pulse-chase studies to be a precursor form of the protein [Dale, B. A., & Ling, S. Y. (1979) Biochemistry 18, 3539-3546], were compared for functional, biochemical, and physical properties. Filaggrin reacts with keratin filaments to form visible macrofibrils, unlike the precursor
J D, Lonsdale-Eccles, D C, Teller, B A, Dale   +2 more
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Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin

Journal of Allergy and Clinical Immunology, 2013
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by a disturbed epidermal barrier. In a subset of patients, this is explained by nonsense mutations in the gene encoding filaggrin (FLG).We sought to evaluate the respective role of FLG mutations and proinflammatory cytokines and to assess the expression of FLG, hornerin (HRNR),
Laurence, Pellerin, Julie, Henry, Chiung-Yueh, Hsu, Stéfana, Balica, Catherine, Jean-Decoster, Marie-Claire, Méchin, Britta, Hansmann, Elke, Rodriguez, Stefan, Weindinger, Anne-Marie, Schmitt, Guy, Serre, Carle, Paul, Michel, Simon   +12 more
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Characterization of canine filaggrin: gene structure and protein expression in dog skin

Veterinary Dermatology, 2013
Background –  Filaggrin (FLG) is a key protein for skin barrier formation and hydration of the stratum corneum. In humans, a strong association between FLG gene mutations and atopic dermatitis has been reported. Although similar pathogenesis and clinical manifestation have been argued in canine atopic dermatitis, our understanding of canine FLG is ...
Satoko, Kanda, Takashi, Sasaki, Aiko, Shiohama, Koji, Nishifuji, Masayuki, Amagai, Toshiroh, Iwasaki, Jun, Kudoh   +6 more
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Gene regulation of filaggrin and other skin barrier proteins via aryl hydrocarbon receptor

Journal of Dermatological Science, 2015
Aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that binds to structurally diverse chemicals including dioxins, coal tar, flavonoids and tryptophan photoproducts. Upon ligation, cytoplasmic AHR translocates to the nucleus, heterodimerizes with aryl hydrocarbon receptor nuclear translocator and mediates numerous biological ...
Masutaka, Furue, Gaku, Tsuji, Chikage, Mitoma, Takeshi, Nakahara, Takahito, Chiba, Saori, Morino-Koga, Hiroshi, Uchi   +6 more
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Antibodies Against Citrullinated Proteins and Filaggrin

2014
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the joints. Rheumatoid arthritis is diagnosed by its clinical features, radiography, and serological tests. An important serological test is the determination of antibodies against citrullinated proteins (ACPA).
Katleen F. E. Van Steendam, Dieter L. Deforce   +1 more
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Inflammatory-Driven Depletion of Filaggrin Proteins

2014
Filaggrin has become the major research focus within the field of skin barrier abnormality over the last 5–10 years. Null mutations in the (pro)-filaggrin gene (FLG) have been shown to be a major risk factor for the development of atopic dermatitis, a disease in which one of the hallmarks is a decreased skin barrier function.
Vestergaard, Christian, Deleuran, Mette
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Biosynthetic pathways of filaggrin and loricrin—two major proteins expressed by terminally differentiated epidermal keratinocytes

Journal of Structural Biology, 1990
We have used immunoelectron microscopy to map the biosynthetic pathways of loricrin and filaggrin in epidermal keratinocytes at successive stages of differentiation in newborn mouse skin. The filaggrin epitope is first detected in large, irregularly shaped, keratohyalin granules (F-granules) in the stratum granulosum, and then distributed throughout ...
A C, Steven, M E, Bisher, D R, Roop, P M, Steinert   +3 more
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Assessment of Serum Interleukin-4 and Filaggrin Protein in Patients with Atopic Dermatitis

Medico-Legal Update, 2020
The current study aimed to determine the relationship between certain immunological parameters inatopicdermatitis (AD) patients.There wasno significant differences (P?0.05)in the level offilaggrin protein between patients and controlgroups regarding to the age but there wasa significant differences (P?
openaire   +1 more source

Calcifying Odontogenic Cysts: Co-Expression of Intermediate Filament Proteins, and Immunohistochemical Distribution of Keratins, Involucrin, and Filaggrin

Pathology - Research and Practice, 1989
The epithelia lining the cyst of five cases of calcifying odontogenic cyst (COC) were evaluated immunohistochemically with the use of monoclonal antibodies (MoAb's) against keratin (PKK1, KL1, K4.62, K8.12) and vimentin, and polyclonal antisera agonist involucrin and filaggrin.
K, Kakudo, K, Mushimoto, R, Shirasu, T, Kasai, K, Yamada, M, Mori   +5 more
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Detection of Several Families of Deiminated Proteins Derived from Filaggrin and Keratins in Guinea Pig Skin

Zoological Science, 1996
Abstract Structural proteins in the mammalian epidermis contain citrulline residues generated by enzymatic deimination of arginine residues. We analyzed deiminated proteins solubilized from sequentially stripped layers of guinea pig epidermis. Deiminated proteins were localized in the granular and cornified layers.
Shuhei Kan, Hiroaki Asaga, Tafsuo Senshu
openaire   +1 more source