Efficacy evaluation of the S-adenosylhomocysteine hydrolase inhibitor MSD-914 in rhesus macaques (Macaca Mulatta) challenged with Ebola virus by the intramuscular route. [PDF]
Johnston SC +28 more
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Marburg Virus Disease in Rwanda - Centering Both Evidence and Equity. [PDF]
Nutt CT.
europepmc +1 more source
Infection-sensing minigenome as a novel therapeutic approach against Ebola virus. [PDF]
Wang L +4 more
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Global trends in Marburg virus disease: Another potential threat to global health in the making? [PDF]
Ahmad T.
europepmc +1 more source
Structures of Marburgvirus glycoprotein and its complex with NPC1 receptor. [PDF]
Ye G +7 more
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mSphere of Influence: The perfect slice-from pizza to proteases. [PDF]
Lennemann NJ.
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Correlates of Immunity to Filovirus Infection
Filoviruses can cause severe, often fatal hemorrhagic fever in humans. Recent advances in vaccine and therapeutic drug development have provided encouraging data concerning treatment of these infections.
Steven B Bradfute, Sina Bavari
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Mouse Models for Filovirus Infections [PDF]
The filoviruses marburg- and ebolaviruses can cause severe hemorrhagic fever (HF) in humans and nonhuman primates. Because many cases have occurred in geographical areas lacking a medical research infrastructure, most studies of the pathogenesis of filoviral HF, and all efforts to develop drugs and vaccines, have been carried out in biocontainment ...
Steven B Bradfute +2 more
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The Role of Cytokines and Chemokines in Filovirus Infection [PDF]
Ebola- and marburgviruses are highly pathogenic filoviruses and causative agents of viral hemorrhagic fever. Filovirus disease is characterized by a dysregulated immune response, severe organ damage, and coagulation abnormalities. This includes modulation of cytokines, signaling mediators that regulate various components of the immune system as well as
Sandra L Bixler, Arthur J Goff
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Family Filoviridae, which includes Ebola virus (EBOV) and Marburg virus (MARV), is a growing threat to human and non-human primate populations in central Africa. Although many facets of the filovirus life cycle remain to be deciphered, a great deal has been learned in recent years. In particular, a clearer understanding of the roles played by viral, as
Yoshihiro Kawaoka
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