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Filovirus helical nucleocapsid structures
Microscopy, 2022Abstract Filoviruses are filamentous enveloped viruses belonging to the family Filoviridae, in the order Mononegavirales. Some filovirus members, such as Ebola virus and Marburg virus, cause severe hemorrhagic fever in humans and non-human primates.
Shangfan Hu, Takeshi Noda
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Virus Research, 2004
Family Filoviridae, which includes Ebola virus (EBOV) and Marburg virus (MARV), is a growing threat to human and non-human primate populations in central Africa. Although many facets of the filovirus life cycle remain to be deciphered, a great deal has been learned in recent years. In particular, a clearer understanding of the roles played by viral, as
Luke D, Jasenosky, Yoshihiro, Kawaoka
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Family Filoviridae, which includes Ebola virus (EBOV) and Marburg virus (MARV), is a growing threat to human and non-human primate populations in central Africa. Although many facets of the filovirus life cycle remain to be deciphered, a great deal has been learned in recent years. In particular, a clearer understanding of the roles played by viral, as
Luke D, Jasenosky, Yoshihiro, Kawaoka
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2018
Filoviruses are highly filamentous enveloped animal viruses that can cause severe haemorrhagic fevers. The filovirus ribonucleoprotein forms a highly organized double-layered helical nucleocapsid (NC) containing five different virally encoded proteins. The inner layer consists of NP, the RNA binding protein, complexed with the monopartite linear genome.
Daniel R, Beniac +2 more
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Filoviruses are highly filamentous enveloped animal viruses that can cause severe haemorrhagic fevers. The filovirus ribonucleoprotein forms a highly organized double-layered helical nucleocapsid (NC) containing five different virally encoded proteins. The inner layer consists of NP, the RNA binding protein, complexed with the monopartite linear genome.
Daniel R, Beniac +2 more
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Polymorphism of Filovirus Glycoproteins
2005Publisher Summary Filoviral glycoproteins are encoded by gene 4 (GP gene) of the nonsegmented negative-strand RNA genome. Nonstructural glycoprotein (sGP) as well as Ebola virus (EBOV) and Marburgvirus (MBGV) GP undergo several posttranslational processing steps giving rise to a whole series of different glycoproteins.
Viktor E, Volchkov +4 more
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2017
Filovirus entry into cells is complex, perhaps as complex as any viral entry mechanism identified to date. However, over the past 10 years, the important events required for filoviruses to enter into the endosomal compartment and fuse with vesicular membranes have been elucidated (Fig. 1).
R A, Davey +5 more
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Filovirus entry into cells is complex, perhaps as complex as any viral entry mechanism identified to date. However, over the past 10 years, the important events required for filoviruses to enter into the endosomal compartment and fuse with vesicular membranes have been elucidated (Fig. 1).
R A, Davey +5 more
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[Haemostasis dysregulation in filovirus infections]
Medecine sciences : M/S, 2015(Uploaded by Plazi for the Bat Literature Project) Filoviruses are responsible for highly lethal infections. Those viruses are found in intertropical areas of Africa and Asia where they circulate in their supposed natural reservoir, fruit bats. During filovirus outbreaks and depending on the strains, various modifications in hemostasis have been ...
Olivier, Reynard +2 more
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Therapeutics Against Filovirus Infection
2017Therapies for filovirus infections are urgently needed. The paradoxical issue facing therapies is the need for rigorous safety and efficacy testing, adhering to the principle tenant of medicine to do no harm, while responding to the extreme for a treatment option during an outbreak. Supportive care remains a primary goal for infected patients. Years of
John, Connor +2 more
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Annales de l'Institut Pasteur / Actualités, 1997
Les filovirus, Marburg et Ebola, sont classes au niveau 4 de securite. Leur haute pathogenicite a ete relevee particulierement chez les sous-types Soudan, Zaire et MBGV. Existent plusieurs modes de transmission, le plus frequent etant le contact physique avec le virus.
Heinz Feldmann +2 more
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Les filovirus, Marburg et Ebola, sont classes au niveau 4 de securite. Leur haute pathogenicite a ete relevee particulierement chez les sous-types Soudan, Zaire et MBGV. Existent plusieurs modes de transmission, le plus frequent etant le contact physique avec le virus.
Heinz Feldmann +2 more
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