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Filovirus Infection in Humanized Mouse Models
Since the discovery of filoviruses in 1967, there have been more than 40 outbreaks with high case-fatality rates causing more than 30,000 deaths in humans. Filovirus disease (FVD) involves the dysregulation of many host physiological processes. While many advances in the field have taken place since the first outbreaks, the dearth of small animal ...Estefanía, Rodríguez +2 more
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Production and Purification of Filovirus Glycoproteins
Ebola (EBOV) and Marburg (MARV) viruses cause hemorrhagic fever disease in humans and non-human primates (NHPs) with case-fatality rates as high as 90%. The 2013-2016 Ebola virus disease (EVD) outbreak led to over 28,000 cases and 11,000 deaths and took an enormous toll on the economy of West African nations, in the absence of any vaccine or ...Madeleine, Noonan-Shueh +2 more
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Experimental therapy of filovirus infections
Antiviral Research, 2002Mike, Bray, Jason, Paragas
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Structure-Based Design of Prefusion-Stabilized Filovirus Glycoprotein Trimers
Cell Reports, 2020Lucy Rutten +2 more
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Filovirus pathogenesis and immune evasion: insights from Ebola virus and Marburg virus
Nature Reviews Microbiology, 2015Ilhem Messaoudi +2 more
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