Results 171 to 180 of about 5,486 (195)

Reverse Genetics of Filoviruses

2017
Reverse genetics systems are used for the generation of recombinant viruses. For filoviruses, this technology has been available for more than 15 years and has been used to investigate questions regarding the molecular biology, pathogenicity, and host adaptation determinants of these viruses.
Thomas, Hoenen, Janine, Brandt, Yíngyún, Caì, Jens H, Kuhn, Courtney, Finch   +4 more
openaire   +2 more sources

Rapid detection protocol for filoviruses

Journal of Clinical Virology, 2004
The incidence of filovirus disease outbreaks has been increasing in recent years. Although there have been advances in the developments of diagnostics, field tests are rare. Apart from family members of infected patients, health care workers are at high risk of being infected during the initial phase of an outbreak.
Weidmann, Manfred, Mühlberger, Elke, Hufert, Frank T.   +2 more
openaire   +3 more sources

Arenaviruses and Filoviruses

2015
This chapter focuses on the viral hemorrhagic fever (VHF) viruses from two taxa, the families Arenaviridae and Filoviridae. The family Arenaviridae comprises 29 named viruses, which have unique morphologic and physiochemical characteristics. Antigenic relationships are established mainly on the basis of broadly reactive antibody binding assays ...
Pierre E. Rollin, Stuart T. Nichol, Sherif Zaki, Thomas G. Ksiazek   +3 more
openaire   +1 more source

Emerging and reemerging of filoviruses

1996
Filoviruses are causative agents of a hemorrhagic fever in man with mortalities ranging from 22 to 88%. They are enveloped, nonsegmented negative-stranded RNA viruses and are separated into two types, Marburg and Ebola, which can be serologically, biochemically and genetically distinguished. In general, there is little genetic variability among viruses
H, Feldmann, W, Slenczka, H D, Klenk
openaire   +2 more sources

Fighting filoviruses with antibody therapy

Science, 2017
Emerging Infections Ravn and Marburg viruses cause hemorrhagic fever with high morbidity rates in humans. Mire et al. tested the ability of previously identified human monoclonal antibodies to protect guinea pigs from lethal infection. One candidate antibody was administered 5 days after otherwise lethal Marburg or Ravn infection in nonhuman primates ...
openaire   +2 more sources

Live-Cell Imaging of Filoviruses

2017
Observation of molecular processes inside living cells is fundamental to a deeper understanding of virus-host interactions in filoviral-infected cells. These observations can provide spatiotemporal insights into protein synthesis, protein-protein interaction dynamics, and transport processes of these highly pathogenic viruses.
Gordian, Schudt, Olga, Dolnik, Stephan, Becker   +2 more
openaire   +2 more sources

Vaccine research efforts for filoviruses

International Journal for Parasitology, 2003
Ebola and Marburg viruses belong to the family Filoviridae, and cause acute, frequently fatal, haemorrhagic fever in humans and non-human primates. No vaccines are available for human use. This review describes the status of research efforts to develop vaccines for these viruses and to identify the immune mechanisms of protection.
openaire   +2 more sources

Minigenome Systems for Filoviruses

2017
Filoviruses are among the most pathogenic viruses known to man, and work with live viruses is restricted to maximum containment laboratories. In order to study individual aspects of the virus life cycle outside of maximum containment laboratories, life cycle modeling systems have been established, which use reporter-encoding miniature versions of the ...
openaire   +2 more sources

Filoviruses as emerging pathogens

Seminars in Virology, 1994
Abstract Of all the animal virus families that cause disease in man least is known about members of Filoviridae. This family, which contains Marburg and Ebola viruses, is one member of the order Mononegavirales, RNA viruses with a single negative genomic strand. The natural history of the filoviruses is unknown, but they have on occasion caused small
C.J. Peters, A. Sanchez, H. Feldmann, P.E. Rollin, S. Nichol, T.G. Ksiazek   +5 more
openaire   +1 more source

Reverse Genetics Systems for Filoviruses

2017
Filoviruses are among the most pathogenic viruses known to man. Reverse genetics systems, in particular full-length clone systems, allow the generation of recombinant filoviruses, which can be used to study virus biology, but also for applied uses such as screening for countermeasures.
Thomas, Hoenen, Heinz, Feldmann
openaire   +2 more sources