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Filoviruses as emerging pathogens
Seminars in Virology, 1994Abstract Of all the animal virus families that cause disease in man least is known about members of Filoviridae. This family, which contains Marburg and Ebola viruses, is one member of the order Mononegavirales, RNA viruses with a single negative genomic strand. The natural history of the filoviruses is unknown, but they have on occasion caused small
C.J. Peters +5 more
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Reverse Genetics Systems for Filoviruses
2017Filoviruses are among the most pathogenic viruses known to man. Reverse genetics systems, in particular full-length clone systems, allow the generation of recombinant filoviruses, which can be used to study virus biology, but also for applied uses such as screening for countermeasures.
Thomas, Hoenen, Heinz, Feldmann
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Filoviruses: Ecology, Molecular Biology, and Evolution
2018(Uploaded by Plazi for the Bat Literature Project) The Filoviridae are a family of negative-strand RNA viruses that include several important human pathogens. Ebola virus (EBOV) and Marburg virus are well-known filoviruses which cause life-threatening viral hemorrhagic fever in human and nonhuman primates.
Jackson, Emanuel +2 more
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Inside the Cell: Assembly of Filoviruses
2017This chapter reviews our current knowledge about the spatiotemporal assembly of filoviral particles. We will follow particles from nucleocapsid entry into the cytoplasm until the nucleocapsids are enveloped at the plasma membrane. We will also highlight the currently open scientific questions surrounding filovirus assembly.
Larissa, Kolesnikova +3 more
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2018
Congenital and pediatric Ebola virus disease (EVD) and Marburg virus disease (MVD) are severe, even lethal infections. Historically, children have been underrepresented in filovirus disease outbreaks, and evidence-based treatment strategies are lacking. Existing data suggest that case fatalities are highest among children under four years of age, which
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Congenital and pediatric Ebola virus disease (EVD) and Marburg virus disease (MVD) are severe, even lethal infections. Historically, children have been underrepresented in filovirus disease outbreaks, and evidence-based treatment strategies are lacking. Existing data suggest that case fatalities are highest among children under four years of age, which
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Viral genomics in Ebola virus research
Nature Reviews Microbiology, 2020Nicholas Di Paola +2 more
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