Results 191 to 200 of about 9,748 (234)

Reverse Genetics Systems for Filoviruses

Methods in molecular biology, 2023
Filoviruses are causative agents of severe hemorrhagic fevers with high case fatality rates in humans. For studies of virus biology and the subsequent development of countermeasures, reverse genetic systems, and especially those facilitating the generation of recombinant filoviruses, are indispensable.
Bianca S, Bodmer, Thomas, Hoenen
openaire   +3 more sources

Ecology of Filoviruses

Current Topics in Microbiology and Immunology, 2017
(Uploaded by Plazi for the Bat Literature Project) Filoviruses can cause severe and often fatal disease in humans. To date, there have been 47 outbreaks resulting in more than 31,500 cases of human illness and over 13,200 reported deaths. Since their discovery, researchers from many scientific disciplines have worked to better understand the natural ...
Brian R, Amman, Robert, Swanepoel, Stuart T, Nichol, Jonathan S, Towner   +3 more
openaire   +3 more sources

Filoviruses

2010
Abstract Filoviruses are large RNA viruses, of which Ebola virus and Marburg virus cause the most severe forms of viral haemorrhagic fever and have been best-studied because of fear of their misuse as bioterrorism agents. These are zoonotic viruses with reservoirs, most likely fruit-eating bats, in the rainforests of tropical Africa ...
Dieudonné Nkoghe, Eric Leroy, Médard Toung Mve, Jean Gonzalez   +3 more
  +5 more sources

VP24 matrix proteins of eight filoviruses downregulate innate immune response by inhibiting the interferon-induced pathway.

Journal of General Virology, 2023
Filoviruses encode viral protein 24 (VP24) which effectively inhibit the innate immune responses in infected cells. Here we systematically analysed the effects of nine mammalian filovirus VP24 proteins on interferon (IFN)-induced immune response.
Hira Khan, Lav Tripathi, Pekka Kolehmainen, Rickard Lundberg, E. Altan, Jemna Heroum, I. Julkunen, L. Kakkola, Moona Huttunen   +8 more
semanticscholar   +1 more source

Ligand-based design of peptide entry inhibitors targeting the endosomal receptor binding site of filoviruses.

Antiviral Research, 2022
Filoviruses enter cells through micropinocytosis and trafficking into the endosomes in which they bind to the receptor Niemann-Pick C1 protein (NPC1) for membrane fusion and entry into the cytoplasm.
Leah Liu Wang, L. Estrada, J. Wiggins, Manu Anantpadma, J. J. Patten, R. Davey, S. Xiang   +6 more
semanticscholar   +1 more source

Remdesivir inhibits the polymerases of the novel filoviruses lloviu and Bombali virus.

Antiviral Research, 2021
In recent years, a number of novel filoviruses (e.g. Lloviu virus (LLOV) and Bombali virus (BOMV)) have been discovered. While antibody-based therapeutics have recently been approved for treatment of infections with the filovirus Ebola virus (EBOV), no ...
B. Bodmer, Lukas Zierke, L. Wendt, Josephin Greßler, A. Groseth, T. Hoenen   +5 more
semanticscholar   +1 more source

The discovery and development of novel treatment strategies for filoviruses

Expert Opinion on Drug Discovery, 2021
Introduction Filoviruses are negative-stranded, enveloped RNA viruses that can cause hemorrhagic fever in humans and include Ebola and Marburg viruses. Lethality rates can reach 90% in isolated outbreaks.
Steven B. Bradfute
semanticscholar   +1 more source

Bioterrorism potential of haemorrhagic fever viruses - occupational and environmental Implications of filoviruses and arenaviruses.

Annals of Agricultural and Environmental Medicine
INTRODUCTION AND OBJECTIVE Viral haemorrhagic fevers (VHFs), caused by filoviruses (e.g., Ebola virus, Marburg virus) and arenaviruses (e.g., Lassa virus, Machupo virus), represent a significant bioterrorism threat due to their zoonotic origins, high ...
Natalia Cichoń, Natalia Kurpesa, Marcin Niemcewicz, Marcin Podogrocki, M. Bijak   +4 more
semanticscholar   +1 more source

Ebola virus vaccination elicits Ebola virus-specific immune responses without substantial cross-reactivity to other filoviruses.

Science Translational Medicine
The Janssen Ebola virus (EBOV) vaccine consists of the adenovirus type 26 vector encoding the EBOV glycoprotein (GP) (Ad26.ZEBOV) and the modified vaccinia Ankara (MVA) vector encoding GP from EBOV, Sudan virus, and Marburg virus and nucleoprotein from ...
T. Mdluli, Suzanne Wollen-Roberts, Mélanie Merbah, B. Beckman, Yifan Li, Aljawharah Alrubayyi, Daniel J. Curtis, Zhanna Shubin, Michael D Barrera, Jacob Boeckelman, Shayla Duncan, Pallavi Thapa, Dohoon Kim, Margaret C Costanzo, Hongjun Bai, Bethany L. Dearlove, Jay W Hooper, S. Kwilas, Dominic Paquin-Proulx, M. Eller, L. Eller, H. Kibuuka, Betty Mwesigwa, Josphat Kosgei, Fredrick Sawe, Janet Oyieko, N. Ntinginya, Joel Mwakisisile, I. Jani, Edna O Viegas, M. Iroezindu, A. Akintunde, Kristopher Paolino, M. Robb, Lucy Ward, Chelsea McLean, K. Luhn, Cynthia Robinson, J. Ake, M. Rolland   +39 more
semanticscholar   +1 more source