Results 201 to 210 of about 9,748 (234)

An update on nonhuman primate usage for drug and vaccine evaluation against filoviruses

Expert Opinion on Drug Discovery
Introduction Due to their faithful recapitulation of human disease, nonhuman primates (NHPs) are considered the gold standard for evaluating drugs against Ebolavirus and other filoviruses.
Marc-Antoine de La Vega, Ara Xiii, Shane Massey, J. Spengler, Gary P. Kobinger, Courtney Woolsey   +5 more
semanticscholar   +1 more source

Monoterpenoid-based inhibitors of filoviruses targeting the glycoprotein-mediated entry process.

European journal of medicinal chemistry, 2020
In this study, we screened a large library of (+)-camphor and (-)-borneol derivatives to assess their filovirus entry inhibition activities using pseudotype systems.
A. Sokolova, O. Yarovaya, A. V. Zybkina, E. D. Mordvinova, N. S. Shcherbakova, A. V. Zaykovskaya, D. Baev, T. Tolstikova, D. Shcherbakov, O. Pyankov, R. Maksyutov, N. Salakhutdinov   +11 more
semanticscholar   +1 more source

(+)-fenchol and (-)-isopinocampheol derivatives targeting the entry process of filoviruses.

European journal of medicinal chemistry
The increasing frequency of filovirus outbreaks in African countries has led to a pressing need for the development of effective antifilovirus agents. In continuation of our previous research on the antifilovirus activity of monoterpenoid derivatives, we
A. Sokolova, D. Baev, E. D. Mordvinova, O. Yarovaya, N. V. Volkova, D. Shcherbakov, A. A. Okhina, A. Rogachev, T. A. Shnaider, Anastasiya S. Chvileva, T. Nikitina, T. Tolstikova, N. Salakhutdinov   +12 more
semanticscholar   +1 more source

Host-pathogen interactions of emerging zoonotic viruses: bats, humans and filoviruses.

Current Opinion in Virology
This paper provides an overview of the phenomena of cross-species transmission of viruses (known as spillover), focusing on the highly pathogenic filovirus family and their natural reservoir: bats.
Grace Hood, Miles W. Carroll
semanticscholar   +1 more source

Filoviruses

1993
Abstract The viral family known as the Filoviridae is unique among animal virus families: we understand virtually nothing about the natural history and maintenance strategies of any member of the family, yet Marburg and Ebola viruses are highly pathogenic for man and are capable of epidemic transmission (Table 15.1). Surely they are a
C J Peters, E D Johnson, P B Jahrling, T G Ksiazek, P E Rollin, J White, W Hall, R Trotter,, N Jaax   +8 more
openaire   +1 more source

Examining the Role of Niemann-Pick C1 Protein in the Permissiveness of Aedes Mosquitoes to Filoviruses.

ACS Infectious Diseases, 2020
Aedes mosquitoes vector many viruses with divergent characteristics, yet the criteria needed for a virus to be vectored by an arthropod remain unknown.
Alexander S. Gold, Fabiana Feitosa-Suntheimer, S. Asad, Bukola Adeoye, J. Connor, T. Colpitts   +5 more
semanticscholar   +1 more source

Reverse Genetics of Filoviruses

2017
Reverse genetics systems are used for the generation of recombinant viruses. For filoviruses, this technology has been available for more than 15 years and has been used to investigate questions regarding the molecular biology, pathogenicity, and host adaptation determinants of these viruses.
Thomas, Hoenen, Janine, Brandt, Yíngyún, Caì, Jens H, Kuhn, Courtney, Finch   +4 more
openaire   +2 more sources

Rapid detection protocol for filoviruses

Journal of Clinical Virology, 2004
The incidence of filovirus disease outbreaks has been increasing in recent years. Although there have been advances in the developments of diagnostics, field tests are rare. Apart from family members of infected patients, health care workers are at high risk of being infected during the initial phase of an outbreak.
Weidmann, Manfred, Mühlberger, Elke, Hufert, Frank T.   +2 more
openaire   +3 more sources

Arenaviruses and Filoviruses

2015
This chapter focuses on the viral hemorrhagic fever (VHF) viruses from two taxa, the families Arenaviridae and Filoviridae. The family Arenaviridae comprises 29 named viruses, which have unique morphologic and physiochemical characteristics. Antigenic relationships are established mainly on the basis of broadly reactive antibody binding assays ...
Pierre E. Rollin, Stuart T. Nichol, Sherif Zaki, Thomas G. Ksiazek   +3 more
openaire   +1 more source

Ecological Niche Modeling for Filoviruses: A Risk Map for Ebola and Marburg Virus Disease Outbreaks in Uganda

PLOS Currents, 2017
Introduction: Uganda has reported eight outbreaks caused by filoviruses between 2000 to 2016, more than any other country in the world. We used species distribution modeling to predict where filovirus outbreaks are likely to occur in Uganda to help in ...
L. Nyakarahuka, S. Ayebare, G. Mosomtai, Clovice Kankya, J. Lutwama, F. Mwiine, E. Skjerve   +6 more
semanticscholar   +1 more source