Results 61 to 70 of about 13,264 (267)
Structure-based discovery of glycomimetic FmlH ligands as inhibitors of bacterial adhesion during urinary tract infection [PDF]
, 2018 Significance
The emergence of multidrug-resistant bacteria, including uropathogenic
Escherichia coli
(UPEC), makes the development of targeted antivirulence therapeutics a critical focus of research.Chugani, Ryan, Conover, Matt S., Hibbing, Michael E., Hultgren, Scott J., Janetka, James W., Kalas, Vasilios, Maddirala, Amarendar Reddy, Mydock-McGrane, Laurel K., Pinkner, Jerome S. +8 morecore +2 more sourcesPoint mutations in FimH adhesin of Crohn's disease-associated adherent-invasive Escherichia coli enhance intestinal inflammatory response.
PLoS Pathogens, 2013 Adherent-invasive Escherichia coli (AIEC) are abnormally predominant on Crohn's disease (CD) ileal mucosa. AIEC reference strain LF82 adheres to ileal enterocytes via the common type 1 pili adhesin FimH and recognizes CEACAM6 receptors abnormally ...Nicolas Dreux, Jérémy Denizot, Margarita Martinez-Medina, Alexander Mellmann, Maria Billig, Dagmara Kisiela, Sujay Chattopadhyay, Evgeni Sokurenko, Christel Neut, Corinne Gower-Rousseau, Jean-Frédéric Colombel, Richard Bonnet, Arlette Darfeuille-Michaud, Nicolas Barnich +13 moredoaj +1 more sourceThe adherent/invasive escherichia coli (AIEC) strain LF82 invades and persists in human prostate cell lineRWPE-1 activating a strong inflammatory response [PDF]
, 2016 Adherent/invasive Escherichia coli (AIEC) strains have recently been receiving increased attention because they are more prevalent and persistent in the intestine of Crohn's disease (CD) patients than in healthy subjects.ALEANDRI, MARTA, Ambrosi, C, Conte, Al, CONTE, Maria Pia, De Cesaris, P, GAMBARA, Guido, LONGHI, Catia, Marazzato, Massimiliano, Nicoletti, M, PALAMARA, ANNA TERESA, PALOMBI, Fioretta, RICCIOLI, ANNA, ZAGAGLIA, Carlo, ZIPARO, Elio +13 morecore +2 more sourcesMechano-transduction: from molecules to tissues. [PDF]
, 2014 External forces play complex roles in cell organization, fate, and homeostasis. Changes in these forces, or how cells respond to them, can result in abnormal embryonic development and diseases in adults.Dunn, Alexander R, Nelson, W James, Pruitt, Beth L, Weis, William I +3 morecore +2 more sourcesFimH confers mannose-targeting ability to Bacillus Calmette-Guerin for improved immunotherapy in bladder cancer
Journal for ImmunoTherapy of Cancer, 2022 Background Bladder cancer is a common disease worldwide with most patients presenting with the non-muscle-invasive form (NMIBC) at initial diagnosis. Postoperational intravesical instillation of BCG is carried out for patients with high-risk disease to ...Yang-Xun Zhang, Fan Huo, Q. Cao, Ru Jia, Qiju Huang, Zhu A. Wang, D. Theodorescu, Q. Lv, Pengchao Li, Chao Yan +9 moresemanticscholar +1 more sourceInnovative solutions to sticky situations: Antiadhesive strategies for treating bacterial infections [PDF]
, 2016 Bacterial adherence to host tissue is an essential process in pathogenesis, necessary for invasion and colonization and often required for the efficient delivery of toxins and other bacterial effectors.Aberg, Abgottspon, Allen, Allison, Alves, Aminov, Anderson, Andersson, Andersson, Andreini, Anthouard, Arnqvist, Aronson, Arrecubieta, Ashkar, Autar, Avorn, Bajolet-Laudinat, Barbosa-Cesnik, Barczak, Barnhart, Barnhart, Barocchi, Blanco, Bouckaert, Bouckaert, Boukerb, Boyle, Branderhorst, Breimer, Breimer, Briles, Britton, Brown, Buffie, Candela, Cecioni, Cecioni, Cegelski, Chabre, Chagnot, Chang, Chapman, Chemani, Chen, Chen, Chorell, Choudhury, Cioci, Clatworthy, Cole, Coppa, Cossart, Costerton, Cozens, Cusumano, Dam, Delnay, DePas, Dethlefsen, Diggle, Dodson, Donlan, Dramsi, Ebersbach, Eto, Evans, Fagon, Falugi, Ferreira, Findlow, Finlay, Finlay, Fischetti, Flores-Mireles, Foo, Ford, Foxman, Frankel, Furiga, Gao, Garcia-Medina, Gaudreau, Geibel, Gellatly, Ghosh, Giugliano, Glick, Goller, Gouin, Goyal, Greco, Greene, Griebling, Guiton, Guiton, Guiton, Guiton, Gustafsson, Guttilla, Haataja, Hakkarainen, Hammar, Hammer, Hammer, Hampton, Han, Han, Hansson, Hart, Haslam, Hauck, Hawley, Hentzer, Hernell, Hofmann, Hollenbeck, Horvath, Howell, Hung, Hung, Hur, Hur, Idanpaan-Heikkila, Isberg, Jacob-Dubuisson, Jay, Jiang, Jones, Jones, Joosten, Juliano, Kadam, Kadam, Kai-Larsen, Kang, Kang, Kauppi, Keeney, Kelly, Kierek-Pearson, Kim, Kim, Kim, Kisiela, Kleeb, Klein, Klein, Klein, Kline, Kontiokari, Konto-Ghiorghi, Korhonen, Kozel, Krachler, Krachler, Krachler, Kruger, Kummerfeldt, Langermann, Langermann, Lanne, Lanne, Larsson, Lebeaux, Lee, Lee, Lee, Lehner, Lewis, Li, Liu, Liukkonen, Lo, Loveless, Lund, Lyczak, Ma, Mack, Mamo, Mandlik, Manefield, Mapingire, Maresso, Maresso, Maresso, Marotte, Marraffini, Mayville, Mazmanian, Mazmanian, Menard, Migone, Migone, Miller, Mitchell, Morrow, Morvan, Munera, Murray, Mysore, Nallapareddy, Neeser, Nenninger, Nenninger, Newburg, Nicolle, Nielsen, Nielsen, Nielubowicz, Nishikawa, Nishikawa, Nishiyama, Nuccio, O'Toole, Ofek, Ofek, Oh, Oh, Oh, Ohlsson, Ohlsson, Okuda, Olsen, Oppong, Orndorff, Otsuka, Paganelli, Pak, Palumbi, Pang, Park, Parker, Patel, Perret, Pertici, Peychl, Phan, Piatek, Pieters, Pinkner, Prabu, Proft, Puorger, Pusztai, Raghunathan, Rapsinski, Rasko, Remaut, Remaut, Rivera, Roberts, Robinson, Rosen, Ruiz-Palacios, Saeki, Saldana, Salminen, Sauer, Sauer, Savar, Scharenberg, Schlager, Schneewind, Schroten, Schulte, Schwardt, Scott, Sekirov, Serruto, Sheth, Shu, Signoretto, Smith, Song, Staat, Stamm, Starkey, Steadman, Stromqvist, Su, Svensson, Thanassi, Therrien, Thomas, Tielker, Toivanen, Ton-That, Ton-That, Ton-That, Ton-That, Turgeon, Ubeda, Van Houdt, Vangay, Vengadesan, Volkan, Walsh, Wang, Wang, Wellens, Whittaker, Wilson, Wolinsky, Wu, Wu, Wurpel, Xiao, Yamaguti-Sasaki, Yamanaka, Yanagawa, Younson, Zhang, Zhang, Zinger-Yosovich +314 morecore +2 more sourcesStructure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH
Nature Structural & Molecular Biology, 2022 Glycoprotein 2 (GP2) and uromodulin (UMOD) filaments protect against gastrointestinal and urinary tract infections by acting as decoys for bacterial fimbrial lectin FimH. By combining AlphaFold2 predictions with X-ray crystallography and cryo-EM, we show A. Stsiapanava, Chenrui Xu, S. Nishio, L. Han, Nao Yamakawa, M. Carroni, Kathryn Tunyasuvunakool, J. Jumper, D. de Sanctis, Bin Wu, L. Jovine +10 moresemanticscholar +1 more sourceMolecular Characterization of theEscherichia coliFimH Adhesin [PDF]
The Journal of Infectious Diseases, 2001 Bacterial adherence mediated by fimbriae is an essential prerequisite for colonization of the urinary tract. Uropathogenic Escherichia coli express a number of different adhesive organelles, including P, type 1, S, and F1C fimbriae [1]. Type 1, or mannose-sensitive, fimbriae are produced by >80% of all uropathogenic E. coli.Schembri, M. A., Kjaergaard, K., Sokurenko, E. V., Klemm, P. +3 moreopenaire +3 more sourcesPhylogeny, Resistome, and Virulome of Escherichia coli Causing Biliary Tract Infections [PDF]
, 2019 Escherichia coli is the most frequent Gram-negative bacilli involved in intra-abdominal infections. However, despite high mortality rates associated with biliary tract infections due to E. coli, there is no study focusing on this pathogen. In this study, Aznar Martín, Javier, Bonnin, Rémy A., Lepe, José A., Naas, Thierry, Ortiz de la Rosa, José Manuel, Pachón, Jerónimo, Rodríguez-Villodres, Ángel, Smani, Younes, Álvarez-Marín, Rocío +8 morecore +2 more sources
