Results 31 to 40 of about 24,950 (282)

Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride

Nature Communications, 2020
Human steroid 5α-reductase 2 (SRD5A2) is an integral membrane enzyme in steroid metabolism and catalyzes the reduction of testosterone to dihydrotestosterone.
Qingpin Xiao, Lei Wang, Shreyas Supekar, Tao Shen, Heng Liu, Fei Ye, Junzhou Huang, Hao Fan, Zhiyi Wei, Cheng Zhang   +9 more
semanticscholar   +1 more source

Influence of Postoperative Finasteride Therapy on Recurrence of Gynecomastia After Mastectomy in Men Taking Finasteride for Alopecia

American Journal of Men's Health, 2019
Finasteride is commonly used for treatment of alopecia. Because finasteride is a cause of gynecomastia, there is concern regarding the continuation of finasteride therapy after mastectomy.
Seung Geun Lee MD, PhD, Pyoung Jae Park MD, PhD, Sung Ryul Lee MD, PhD, Bum Hwan Koo MD, PhD, Geon Young Byun MD, Myoung Jin Kim MD, Hyok Jo Kang MD, Sarang Kim BSN, RN, Beom Seok Oh BSBC, Young Hyun Lee BSDS   +9 more
doaj   +1 more source

Does treatment with dutasteride or finasteride has impact on renal morphology? Experimental study

Acta Cirúrgica Brasileira, 2021
Purpose: To investigate whether renal modifications occur following treatment with dutasteride or finasteride. Methods: Twenty-four male rats were divided into three groups: control (that received distilled water), dutasteride (0.5 mg/kg/day), and ...
Marcello Henrique Araújo da Silva, João Henrique Duque Estrada, Bianca Martins Gregório, Francisco José Barcellos Sampaio, Diogo Benchimol de Souza   +4 more
doaj   +1 more source

Systematic Review of Platelet-Rich Plasma Use in Androgenetic Alopecia Compared with Minoxidil®, Finasteride®, and Adult Stem Cell-Based Therapy

International Journal of Molecular Sciences, 2020
The number of articles evaluating platelet-rich plasma (PRP) efficacy in androgenic alopecia (AGA) have exponentially increased during the last decade.
P. Gentile, S. Garcovich
semanticscholar   +1 more source

Untargeted Metabolomics and Steroid Signatures in Urine of Male Pattern Baldness Patients after Finasteride Treatment for a Year

Metabolites, 2020
Male pattern baldness (MPB) has been associated with dihydrotestosterone (DHT) expression. Finasteride treats MPB by inhibiting 5-alpha reductase and blocking DHT production.
Yu Ra Lee, Eunju Im, Haksoon Kim, Bark Lynn Lew, Woo-Young Sim, Jeongae Lee, Han Bin Oh, Ki Jung Paeng, Jongki Hong, Bong Chul Chung   +9 more
doaj   +1 more source

Pregnancy and neonatal outcome with maternal exposure to finasteride: Case series

Journal of Dermatology and Dermatologic Surgery, 2021
Background: Finasteride, a type II 5-α reductase inhibitor, is approved for the management of benign prostate hyperplasia and male pattern hair loss. Finasteride is used off-label for female pattern hair loss. In utero fetal exposure to finasteride might
Hessah F BinJadeed, Abdulmajeed Alajlan
doaj   +1 more source

The effectiveness of reducing the daily dose of finasteride in men with benign prostatic hyperplasia

BMC Urology, 2002
Background Finasteride, a 5 alpha reductase inhibitor, is an established treatment for benign prostatic hyperplasia. The recommended dosage is 5 mg a day, however case reports have show effectiveness with lower doses.
Geller Jack, Sullivan Michael J
doaj   +1 more source

Three-Dimensional Proteome-Wide Scale Screening for the 5-Alpha Reductase Inhibitor Finasteride: Identification of a Novel Off-Target

Journal of Medicinal Chemistry, 2021
Finasteride, a 5-alpha reductase (5α-R) inhibitor, is a widely used drug for treating androgen-dependent conditions. However, its use is associated with sexual, psychological, and physical complaints, suggesting that other mechanisms, in addition to 5α-R
S. Giatti, A. Di Domizio, S. Diviccaro, E. Falvo, D. Caruso, A. Contini, R. Melcangi   +6 more
semanticscholar   +1 more source

The 5α-reductase inhibitor finasteride reduces opioid self-administration in animal models of opioid use disorder.

Journal of Clinical Investigation, 2021
Opioid use disorder (OUD) has become a leading cause of death in the US, yet current therapeutic strategies remain highly inadequate. To identify novel potential treatments for OUD, we screened a targeted selection of over 100 drugs using a recently ...
Gabriel D. Bossé, R. Cadeddu, Gabriele Floris, R. Farero, Eva Vigato, S. Lee, Tejia Zhang, N. Gaikwad, K. Keefe, P. E. Phillips, M. Bortolato, R. Peterson   +11 more
semanticscholar   +1 more source

Antioxidant and Antiproliferative Activity of Finasteride against Glioblastoma Cells

Pharmaceutics, 2021
Glioblastoma is an actively growing and aggressive brain tumor with a high propensity of recurrence. Although the surgical removal of tumor mass is the primary therapeutic option against glioblastoma, supportive pharmacotherapy is highly essential due to
H. Kim, Tae-Jun Kim, Yu Gyung Kim, Chaeeun Seong, Jin-Hwa Cho, Wanil Kim, Kyung‐Ha Lee, Do-Yeon Kim   +7 more
semanticscholar   +1 more source