Results 41 to 50 of about 24,950 (282)

Health Risks Associated with Long-Term Finasteride and Dutasteride Use: It's Time to Sound the Alarm

The World Journal of Men's Health, 2020
5α-dihydrotestosterone (5α-DHT) is the most potent natural androgen. 5α-DHT elicits a multitude of physiological actions, in a host of tissues, including prostate, seminal vesicles, hair follicles, skin, kidney, and lacrimal and meibomian glands. However,
A. Traish
semanticscholar   +1 more source

Finasteride and Erectile Dysfunction in Patients with Benign Prostatic Hyperplasia or Male Androgenetic Alopecia

The World Journal of Men's Health, 2019
Finasteride is primarily used to treat benign prostatic hyperplasia (BPH) and male androgenetic alopecia (MAA). Five-alpha reductase inhibitors (5α-RIs) could induce male sexual dysfunction due to their effects on testosterone and dihydrotestos-terone ...
Yu Seob Shin, Keshab Kumar Karna, Bo Ram Choi, Jong Kwan Park   +3 more
doaj   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Finasteride delays atherosclerosis progression in mice and is associated with a reduction in plasma cholesterol in men

Journal of Lipid Research
Finasteride is commonly prescribed to treat benign prostate hyperplasia and male-pattern baldness in cis men and, more recently, trans individuals. However, the effect of finasteride on cardiovascular disease remains elusive.
Patrick McQueen, Donald Molina, Ivan Pinos, Samuel Krug, Anna J. Taylor, Michael R. LaFrano, Maureen A. Kane, Jaume Amengual   +7 more
doaj   +1 more source

Anti-proliferative activities of finasteride in benign prostate epithelial cells require stromal fibroblasts and c-Jun gene. [PDF]

PLoS ONE, 2017
This study aimed to identify the role of mouse fibroblast-mediated c-Jun and IGF-1 signaling in the therapeutic effect of finasteride on benign prostatic epithelial cells.
Kai Wang, Song Jin, Dongdong Fan, Mingshuai Wang, Nianzeng Xing, Yinong Niu   +5 more
doaj   +1 more source

Preparation of finasteride capsules-loaded drug nanoparticles: formulation, optimization, in vitro, and pharmacokinetic evaluation

, 2016
Tarek A Ahmed1,2 1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia; 2Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Cairo,
Tarek Ahmed, Ahmed TA
core   +1 more source

Integrating Prostate‐Specific Antigen Density and Prostate Imaging Reporting and Data System Scores to Optimize Detection of Clinically Significant Prostate Cancer: A Multivariable Risk Model Approach

Journal of Clinical Laboratory Analysis, EarlyView.
For the detection of clinically significant prostate cancer, incorporating PSA density into PI‐RADS‐based assessment improved clinical net benefit compared with PI‐RADS alone. The addition of DRE and age to this combined model produced only marginal further gain, indicating that most of the incremental clinical value was derived from PSA density rather
Yunus Kayali
wiley   +1 more source

Tissue Effects in a Randomized Controlled Trial of Short-term Finasteride in Early Prostate Cancer

EBioMedicine, 2016
Background: In the Prostate Cancer Prevention Trial, finasteride selectively suppressed low-grade prostate cancer and significantly reduced the incidence of prostate cancer in men treated with finasteride compared with placebo.
Jeri Kim, John W. Davis, Eric A. Klein, Cristina Magi-Galluzzi, Yair Lotan, John F. Ward, Louis L. Pisters, Joseph W. Basler, Curtis A. Pettaway, Andrew Stephenson, Elsa M. Li Ning Tapia, Eleni Efstathiou, Xuemei Wang, Kim-Anh Do, J. Jack Lee, Ivan P. Gorlov, Lana A. Vornik, Ashraful M. Hoque, Ina N. Prokhorova, Howard L. Parnes, Scott M. Lippman, Ian M. Thompson, Powel H. Brown, Christopher J. Logothetis, Patricia Troncoso   +24 more
doaj   +1 more source

Lipid and Foam Cell Accumulation as Novel Pathological Features of Benign Prostatic Hyperplasia

The Prostate, EarlyView.
ABSTRACT Background Benign prostatic hyperplasia (BPH) encompasses a heterogeneous set of pathological processes that instigate lower urinary tract symptoms (LUTS). Using a mouse model of steroid hormone imbalance–induced lower urinary tract dysfunction, we identified luminal lipid‐laden foamy macrophages, although their presence and contribution to ...
Dita Julianingsih, Samara V. Silver, Thaissa Horne, Kasun Gunawardena, Savannah Ward, Alicia Malewska, Douglas Strand, Julius Nyalwidhe, Ilya Sobol, Petra Popovics   +9 more
wiley   +1 more source

Structure of human steroid 5α-reductase 2 with anti-androgen drug finasteride

Research Square, 2020
Human steroid 5α-reductase 2 (SRD5α2) as a critical integral membrane enzyme in steroid metabolism catalyzes testosterone to dihydrotestosterone. Mutations on its gene have been linked to 5α-reductase deficiency and prostate cancer.
Qingpin Xiao, Lei Wang, Shreyas Supekar, Tao Shen, Heng Liu, Fei Ye, Junzhou Huang, Hao Fan, Zhiyi Wei, Cheng Zhang   +9 more
semanticscholar   +1 more source