Results 61 to 70 of about 16,896 (199)

Investigation Into the Metabolism and Elimination Behavior of RU 58841, and Its Influence on the Steroid Profile in Humans

open access: yesBiomedical Chromatography, Volume 40, Issue 10, October 2026.
ABSTRACT RU 58841 is a nonsteroidal antiandrogen, developed for the treatment of androgen‐dependent conditions. This study aimed to characterize the human metabolism of RU 58841 for the first time and to assess its systemic exposure following topical administration.
Aylin Okutan   +4 more
wiley   +1 more source

Finasteride-induced depression: new insights into possible pathomechanisms: Finasteride-induced depression

open access: yes, 2010
5-alpha-reductase is involved as a rate-imitating enzyme in the metabolism of steroids. Several 5-alpha-reduced steroids such as dihydrotestosterone, allopregnanolone or tetrahydrocorticosterone have neurotrophic, neuroprotective, and anxiolytic ...
Römer, Benedikt, Gass, Peter
core   +1 more source

Supplementary Material for: Finasteride and Suicide: A Postmarketing Case Series

open access: yes, 2020
Background: In 2011, depression was added to the product labeling of finasteride in the USA. The US Food and Drug Administration’s Adverse Event Reporting System database contains at least 36 death cases for finasteride.
Irwig M.S. (8297481)
core   +1 more source

Cognitive effects of testosterone and finasteride administration in older hypogonadal men

open access: yes, 2014
Stephen E Borst,1 Joshua F Yarrow,2 Carmen Fernandez,1 Christine F Conover,2 Fan Ye,2 John R Meuleman,1 Matthew Morrow,3 Baiming Zou,4 Jonathan J Shuster5 1Geriatric Research, Education and Clinical Center, 2Research Service, 3Pharmacy Service, Malcom ...
Yarrow JF   +8 more
core  

FINASTERIDE-ASSOCIATED MALE INFERTILITY

open access: yes, 2004
Finasteride is a potent and specific inhibitor of the 5α-reductase enzyme in men. Clinical studies have shown that finasteride 1mg/day is effective for promoting hair growth in men with male pattern hair loss. However, there is a concern about the use of
Saade, Ricardo   +12 more
core  

Additive effect of oral LDD175 to tamsulosin and finasteride in a benign prostate hyperplasia rat model

open access: yes, 2018
Bo Ram Choi,1–3 Hye Kyung Kim,4,* Kiran Kumar Soni,1–3 Keshab Kumar Karna,1–3 Sung Won Lee,5 Insuk So,6 Jong Kwan Park1–3,* 1Department of Urology, Chonbuk National University, Jeonju, Republic of Korea; 2Research Institute of ...
Kim HK   +6 more
core  

Finasteride and Its Potential for the Treatment of Female Pattern Hair Loss: Evidence to Date

open access: yesDrug Design, Development and Therapy, 2020
Wimolsiri Iamsumang, Kanchana Leerunyakul, Poonkiat Suchonwanit Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, ThailandCorrespondence: Poonkiat Suchonwanit Email poonkiat@hotmail ...
Iamsumang W   +2 more
doaj  

Screening and confirmation methods of the major urinary metabolite of finasteride–carboxy-finasteride by liquid chromatography–mass spectrometry and liquid chromatography–tandem mass spectrometry

open access: yesActa Pharmaceutica Sinica B, 2012
Screening and confirmation methods of the major urinary metabolite of finasteride–carboxy-finasteride for doping control purpose were developed. Liquid–liquid extraction was adopted for the sample preparation.
Jianli Zhang
doaj   +1 more source

Local Pharmacokinetics and Tolerability of Topically‐Applied Bimatoprost to the Scalp of Male Patients With Androgenetic Alopecia

open access: yesClinical and Translational Science, Volume 19, Issue 9, September 2026.
ABSTRACT Androgenetic alopecia (AGA) is one of the most common causes of hair loss in the male population, characterized by progressive baldness. This study was designed to evaluate the tolerability and local skin pharmacokinetics of bimatoprost in two different formulations in male subjects with AGA.
Sana Khajeh pour   +5 more
wiley   +1 more source

Use of Topical Finasteride in Hirsutism: A Double-blind, Randomized Clinical Trial on Women

open access: yesمجله دانشکده پزشکی اصفهان, 2012
Background: Finasteride partially blocks the conversion of testosterone to dihydrotestosterone through inhibition of 5α-reductase in hair follicles. Finasteride cream can penetrate into the dermis and the hair follicle due to its solubility.
Fariba Iraji   +2 more
doaj  

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