Results 61 to 70 of about 71,417 (302)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Conversations: The Journal of Cavellian Studies, 2022 In this essay, I seek to follow and draw upon resources in Ludwig Wittgenstein (and in an important contemporary follower of his, Iain McGilchrist) in order to pose a radical question. I question here the conventional “wisdom” across philosophical traditions (and cleaved to equally strongly by Cavell and Derrida, and for that matter by Richard Dawkins ...
openaire +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Mackie\u27s Arguement for the Infinite Man [PDF]
, 2019 Theists and non-theists alike have toiled with the characteristics of the Judeo-Christian God and how they may or may not be contradictory with the existence of evil. Some philosophers, such as J. L. Mackie, have decided that God and evil cannot coexist,
Basile, Abigail J
core +1 more source
On standards and values: Between finite actuality and infinite possibility [PDF]
, 2016 This article explores the relation between subjects and standards in a way that is informed by a process orientation to theoretical psychology. Standards are presented as objectifications of values designed to generalize and stabilize experiences of ...
Stenner, Paul
core +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
, 1981 The old spiritual masters told us to be in the world but not of it. We moderns have given this a secular twist. We are in our world — we have values, ways of life, world pictures — but not of it — we are to be aware of our freedom, aware of the ...
Kolb, David
core
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Spinoza today: the current state of Spinoza scholarship [PDF]
, 2009 What I plan to do in this paper is to provide a survey of the ways in which Spinoza’s philosophy has been deployed in relation to early modern thought, in the history of ideas and in a number of different domains of contemporary philosophy, and to offer ...
Duffy, Simon B.
core +1 more source