Results 81 to 90 of about 12,591 (290)
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Finitude after after finitude [PDF]
, 2014 University of Minnesota M.S. thesis. June 2014. Major: Communication Studies. Advisor: Ronald W. Greene. 1 computer file (PDF); ii, 78 pages.This work represents my efforts to rethink the relationship between philosophical materialism and contemporary ...
Frank, Jay Alexander
core
, 2017 This chapter examines the philosophical reflections of Jan Patočka and Martin Heidegger regarding the phenomenology of finitude. It considers Patočka's reading of Heidegger by discussing three texts: the second volume of The Crisis of Meaning, which ...
Françoise Dastur, Robert Vallier
core +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Trans/Form/Ação, 2005 O propósito deste artigo é explicitar o modo como Gadamer reformula a hermenêutica diltheiana (desenvolvida sobre o conceito moderno de vida utilizado como fundamento da noção de auto-consciência histórica), ao formular um novo modo de compreender a ...
Evandro Oliveira de Brito
doaj +1 more source
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
, 2015 an ephemeral sculpture made as part of research within 'Finitude ...
M Needham (13420689) +5 more
core
La question de la finitude chez Françoise Dastur : analyse thématique à partir de son ouvrage La mort : essai sur la finitude [PDF]
, 2023 Le présent mémoire se propose d’analyser la conception originale de la finitude que présente Françoise Dastur dans La mort : Essai sur la finitude. Nous souhaitons mettre en relief la conception de la finitude chez Dastur et les raisons qui l’amènent à ...
Leclerc, Olivier
core
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source