Results 91 to 100 of about 71,417 (302)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The End of the World after the End of Finitude: On a Recently Prominent Speculative Tone in Philosophy [PDF]
, 2017 The chapter studies the speculative realist critique of the notion of finitude and its implications for the theme of the "end of the world" as a teleological and eschatological idea. It is first explained how Quentin Meillassoux proposes to overcome both
Backman, Jussi
core
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Where do the architects live? [PDF]
, 1990 discussion of the extent to which architects can float about history and the inevitable finitude of architectural possibilities from any historical ...
Kolb, David
core
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Revista Latinoamericana de Psicopatologia FundamentalA finalidade deste ensaio é a de realizar a genealogia da clínica, baseando-se para isso no discurso genealógico de Nietzsche e na leitura desse discurso realizada posteriormente por Foucault.
Joel Birman
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Eutanásia, Finitude e Biopolítica
Revista Subjetividades, 2016 Atualmente nossa compreensão acerca do que denominamos vida e morte tem sido pautada por três grandes sistemas de pensamentos. O primeiro, denominado de modelo médicobiológico, parte de três perspectivas distintas, a saber: a perspectiva orgânica, a ...
Sergio Gomes da Silva
doaj
, 2009 An extended review of the English collection of Marcuse's essays and interviews on Heidegger that addresses the philosophical basis of a synthesis of Marx and ...
Angus, Ian
core