Results 71 to 80 of about 71,417 (302)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Death over time: brief notes about death and dying in the West
Estudos de Psicologia (Campinas)This literature review deals with death and the changes in its concept and meanings over time, aiming to relate this to the different social organizations and issues that involve individuality and human finitude. It intends to arouse the reflection about
Rosangela Werlang +1 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
DELTA: Documentação de Estudos em Lingüística Teórica e Aplicada, 2010 This paper aims at contributing to the description of Portuguese from the point of view of Systemic Functional Grammar, particularly in relation to the description of the clause as an exchange.
Carlos A. M. Gouveia
doaj +1 more source
Ethics and science in brazilian legal discourse [PDF]
, 2012 The Brazilian Constitution of 1988 declares Brazil as a Democratic State of Law. This formally democratic legal status has been facing difficulties when it comes to its material implementation.
Cota Marçal, Antônio +1 more
core
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Ensino científico e representações sociais de morte humana
Revista Iberoamericana de Educación, 2006 O ser vivo nasce, cresce, se reproduz e morre. Esse é o ciclo de vida que aprendemos desde criança nas aulas de ciências. Nascer, se desenvolver e morrer são eventos naturais que fazem parte do ciclo de vida de qualquer organismo.
Francisco José Figueiredo Coelho +1 more
doaj
Some Metaphysical Implications of Hegel’s Theodicy [PDF]
, 2012 This paper examines Hegel’s claim that philosophy “has no other object than God‘ as a claim about the essentiality of the idea of God to philosophy. On this idealist interpretation, even atheistic philosophies would presuppose rationally evaluable ideas ...
Redding, Paul
core +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source