Results 61 to 70 of about 2,257 (148)

Hepatitis E Virus ORF1 Polyprotein Harbors a Pocket‐Like Cavity That Is Vital for Virus Replication and Represents a Novel Antiviral Target

Advanced Science, Volume 12, Issue 47, December 18, 2025.
Within the hepatitis E virus (HEV) ORF1 polyprotein, the X domain interacts with viral RNA‐dependent RNA polymerase (RdRp), forming a functional “pocket‐like” cavity (PC) that is crucial for viral replication. Structure‐based screening, surface plasmon resonance (SPR) assays, and HEV model validation collectively identify saikosaponin D and ...
Xiaohui Ding, Dou Zeng, Dan Liu, Yingying Bian, Bin Li, Zheng Li, Qiudi Li, Shiquan Liang, Yunlong Si, Qili Yao, Yibo Ding, Jiahui Zhu, Xiangyang Li, Kuiyang Zheng, Hongbo Guo, Wenshi Wang   +15 more
wiley   +1 more source

Structure‐Based Rational Design of a Selective Hydrolase Inhibitor of the Severe Acute Respiratory Syndrome Coronavirus‐2 Nsp3 Macrodomain

ChemBioChem, Volume 26, Issue 23, November 27, 2025.
Structure‐guided design of a sulfamoyl‐modified analog of GS‐441524 yielded a selective, high‐affinity inhibitor of the SARS‐CoV‐2 macrodomain Nsp3b. The compound occupies the phosphate‐binding pocket, forming a stabilizing hydrogen‐bond network that enhances binding affinity (K_D = 0.86 μM).
Robin Krishnathas, Konstantin S. Mineev, Nikolaos K. Fourkiotis, Franck Touret, Christos Sideras‐Bisdekis, Aikaterini C. Tsika, Santosh Lakshmi Gande, Verena Linhard, Sridhar Sreeramulu, Frank Lennartz, Manfred S. Weiss, Bruno Coutard, Georgios A. Spyroulias, Harald Schwalbe   +13 more
wiley   +1 more source

Understanding the Enigmatic Dance of Immune‐Mediated Viral Infections and Their Pathogenetic Mechanisms

Veterinary Medicine and Science, Volume 11, Issue 5, September 2025.
This graphical representation illustrates the multifaceted nature of the immune response in viral infections, demonstrating both its protective and potentially harmful aspects. While a properly regulated immune reaction facilitates viral clearance and promotes general recovery, an overly robust or misdirected response—exemplified by Type III or Type IV
Muhammed Cesim Karabulut, Tuba Çiğdem Oğuzoğlu   +1 more
wiley   +1 more source

Pharmacokinetics of GS‐441524 following intravenous remdesivir in six cats and results of therapeutic drug monitoring during treatment of feline infectious peritonitis: 22 cases (2021–2024)

Journal of Small Animal Practice, Volume 66, Issue 7, Page 495-506, July 2025.
Objectives This study aimed to: (1) characterise the pharmacokinetics of GS‐441524 following intravenous (iv) administration of 15 mg/kg remdesivir (RDV) in client‐owned cats with feline infectious peritonitis (FIP); (2) document plasma protein binding of GS‐441524 in cats; (3) determine whether trough GS‐441524 plasma concentrations predict ‘simple ...
S. J. Coggins, M. Govendir, J. M. Norris, R. Malik, E. J. Hall, M. F. Thompson, B. Kimble   +6 more
wiley   +1 more source

Repurposing old drugs as antiviral agents for coronaviruses

Biomedical Journal, 2020
Background: New therapeutic options to address the ongoing coronavirus disease 2019 (COVID-19) pandemic are urgently needed. One possible strategy is the repurposing of existing drugs approved for other indications as antiviral agents for severe acute ...
Cheng-Wei Yang, Tzu-Ting Peng, Hsing-Yu Hsu, Yue-Zhi Lee, Szu-Huei Wu, Wen-Hsing Lin, Yi-Yu Ke, Tsu-An Hsu, Teng-Kuang Yeh, Wen-Zheng Huang, Jiunn-Horng Lin, Huey-Kang Sytwu, Chiung-Tong Chen, Shiow-Ju Lee   +13 more
doaj   +1 more source

Feline Infectious Peritonitis Virus Nsp5 Inhibits Type I Interferon Production by Cleaving NEMO at Multiple Sites

Viruses, 2019
Feline infectious peritonitis (FIP), caused by virulent feline coronavirus, is the leading infectious cause of death in cats. The type I interferon (type I IFN)-mediated immune responses provide host protection from infectious diseases.
Si Chen, Jin Tian, Zhijie Li, Hongtao Kang, Jikai Zhang, Jiapei Huang, Hang Yin, Xiaoliang Hu, Liandong Qu   +8 more
doaj   +1 more source

Predictive factors associated with short‐term mortality in cats with feline infectious peritonitis treated with remdesivir or GS‐441524 or both

Journal of Veterinary Internal Medicine, Volume 39, Issue 1, January/February 2025.
Abstract Background Although most cats with feline infectious peritonitis (FIP) respond to treatment with remdesivir or GS‐441524 or both with uneventful clinical courses, some die despite treatment. Objective Identify predictive factors associated with short‐term mortality in cats with FIP treated with IV remdesivir or PO GS‐441524 or both.
Sho Goto, Tsuyoshi Kamiyoshi, Ryota Iwasaki   +2 more
wiley   +1 more source

Comparative transcriptome analysis of PBMCs in cats diagnosed with and recovered from FIPV

Laboratory Animal Research
Abstract Background Feline infectious peritonitis is a viral disease caused by feline coronavirus an enveloped virus with a single-stranded RNA genome that is approximately 30 kb long. Although FCoV generally causes mild symptoms, approximately 5% of cases progress to death in cats worldwide.
Ju Young Lee, Hyeong Ryeol Cho, Hong-Geun Oh, Jeong Ho Hwang   +3 more
openaire   +3 more sources

Circulation and Genetic Characterizations of Coronaviruses From Companion Animals in Chengdu, Southwest China: One‐Year Postpandemic

Transboundary and Emerging Diseases, Volume 2025, Issue 1, 2025.
Coronaviruses (CoVs) can cross species barriers and endanger public health. Despite reports on their circulation and evolution in companion animals during the pandemic, postpandemic surveillance remains crucial. Therefore, during the first postpandemic year, 309 samples from 263 companion animals (cats and dogs) in Chengdu, China, were detected for ...
Linxuan Liao, Shanshan Wu, Yihang Xu, Mengxi Cao, Xiao Zhang, Liying Yi, Baochao Zhang, Jiayi Chen, Xin Xu, Xiaofang Pei, Francesco Mira   +10 more
wiley   +1 more source

Stably expressed FIPV peplomer protein induces cell fusion and elicits neutralizing antibodies in mice

Virology, 1989
We have established bovine papilloma virus (BPV)-transformed mouse C127 cell lines that synthesize the peplomer protein of the feline infectious peritonitis virus (FIPV) strain 79-1146. For this purpose, a new cassette expression vector pHSL, which carries the Drosophila HSp70 promotor and the polyadenylation signal of the Moloney murine leukemia virus
De Groot, Raoul J., Van Leen, Robert W., Dalderup, Mieke J.M., Vennema, Harry, Horzinek, Marian C., Spaan, Willy J.M.   +5 more
openaire   +2 more sources