Results 81 to 90 of about 3,740 (192)
ChemBioChem, Volume 26, Issue 23, November 27, 2025.Structure‐guided design of a sulfamoyl‐modified analog of GS‐441524 yielded a selective, high‐affinity inhibitor of the SARS‐CoV‐2 macrodomain Nsp3b. The compound occupies the phosphate‐binding pocket, forming a stabilizing hydrogen‐bond network that enhances binding affinity (K_D = 0.86 μM).
Robin Krishnathas +13 more
wiley +1 more source
Repurposing old drugs as antiviral agents for coronaviruses
Biomedical Journal, 2020 Background: New therapeutic options to address the ongoing coronavirus disease 2019 (COVID-19) pandemic are urgently needed. One possible strategy is the repurposing of existing drugs approved for other indications as antiviral agents for severe acute ...
Cheng-Wei Yang +13 more
doaj +1 more source
A review of coronavirus infection in the central nervous system of cats and mice. [PDF]
, 2001 Feline infectious peritonitis (FIP) is a common cause of death in cats. Management of this disease has been hampered by difficulties identifying the infection and determining the immunological status of affected cats and by high variability in the ...
Foley, JE, Leutenegger, C
core
Prevalence of Korean cats with natural feline coronavirus infections [PDF]
, 2011 Background Feline coronavirus is comprised of two pathogenic biotypes consisting of feline infectious peritonitis virus (FIPV) and feline enteric coronavirus (FECV), which are both divided into two serotypes.
Dong-Jun An +5 more
core +1 more source
Transboundary and Emerging Diseases, 2023 Feline infectious peritonitis (FIP), which is caused by feline infectious peritonitis virus (FIPV), is a fatal and immunologically mediated infectious disease among cats. At present, due to the atypical clinical symptoms and clinicopathological changes, the clinical diagnosis of FIP is still difficult.
Liang Xu +13 more
openaire +2 more sources
Veterinary Medicine and Science, Volume 11, Issue 5, September 2025.This graphical representation illustrates the multifaceted nature of the immune response in viral infections, demonstrating both its protective and potentially harmful aspects. While a properly regulated immune reaction facilitates viral clearance and promotes general recovery, an overly robust or misdirected response—exemplified by Type III or Type IV
Muhammed Cesim Karabulut +1 more
wiley +1 more source
Viruses, 2019 Feline infectious peritonitis (FIP), caused by virulent feline coronavirus, is the leading infectious cause of death in cats. The type I interferon (type I IFN)-mediated immune responses provide host protection from infectious diseases.
Si Chen +8 more
doaj +1 more source
Epidemiology and Comparative Analyses of the S Gene on Feline Coronavirus in Central China
Pathogens, 2022 Feline coronavirus (FCoV) infections present as one of two forms: a mild or symptom-less enteric infection (FEC) and a fatal systemic disease termed feline infectious peritonitis (FIP). The lack of epidemiology of FCoV in central China and the reason why
Hehao Ouyang +13 more
doaj +1 more source
Development of monoclonal antibodies (MAbs) to feline interferon (fIFN)-γas tools to evaluate cellular immune responses to feline infectious peritonitis virus (FIPV) [PDF]
Journal of Feline Medicine and Surgery, 2011 Feline infectious peritonitis virus (FIPV) can cause a lethal disease in cats, feline infectious peritonitis (FIP). The antibody-dependent enhancement (ADE) of FIPV infection has been recognised in experimentally infected cats, and cellular immunity is considered to play an important role in preventing the onset of FIP.
Satoh, Ryoichi +8 more
openaire +2 more sources
Journal of Small Animal Practice, Volume 66, Issue 7, Page 495-506, July 2025.Objectives This study aimed to: (1) characterise the pharmacokinetics of GS‐441524 following intravenous (iv) administration of 15 mg/kg remdesivir (RDV) in client‐owned cats with feline infectious peritonitis (FIP); (2) document plasma protein binding of GS‐441524 in cats; (3) determine whether trough GS‐441524 plasma concentrations predict ‘simple ...
S. J. Coggins +6 more
wiley +1 more source