Results 71 to 80 of about 14,327 (227)

Suppression of tumour growth from transplanted astrocytoma cells transfected with luciferase in mice by bioluminescence mediated, systemic, photodynamic therapy

Photodiagnosis and Photodynamic Therapy
Background: Grade 4 astrocytomas are usually incurable due to their diffusely infiltrative nature. Photodynamic therapy (PDT) is a promising therapeutic option, but external light delivery is impractical when cancer cells infiltrate unknown areas of ...
Jane Ng, Nico Henriquez, Neil Kitchen, Norman Williams, Marco Novelli, Dahmane Oukrif, Alexander MacRobert, Stephen Bown   +7 more
doaj   +1 more source

Autophagy Plays a Suppressive Role in Bladder Tumor Formation in an Orthotopic Mouse Model and Bladder Cancer Patient Specimens

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Autophagy plays either a suppressing or promoting role during tumor development. Clarifying the role of autophagy in bladder tumorigenesis both in vitro and in vivo is crucial for developing novel therapeutic strategies through manipulating autophagy activity.
Wan‐Ting Kuo, Chin‐Chen Pan, Yi‐Wen Liu, Nan‐Haw Chow, Hong‐Lin Cheng, Shan‐Ying Wu, Sheng‐Hui Lan, Chih‐Peng Chang, Hsiao‐Sheng Liu   +8 more
wiley   +1 more source

Uptake kinetics and biodistribution of C-14-D-luciferin-a radiolabeled substrate for the firefly luciferase catalyzed bioluminescence reaction: impact on bioluminescence based reporter gene imaging

, 2008
Purpose Firefly luciferase catalyzes the oxidative decarboxylation of D-luciferin to oxyluciferin in the presence of cofactors, producing bioluminescence.
Bhaumik, Srabani, Berger, Frank, Paulmurugan, Ramasamy, Gambhir, Sanjiv Sam   +3 more
core   +1 more source

Firefly Rats: Illuminating the Scientific Community in Transplantation Research

Cell Transplantation
Fireflies produce light through luciferase-catalyzed reactions involving luciferin, oxygen, and adenosine triphosphate, distinct from other luminescent organisms.
Eiji Kobayashi, Yoji Hakamata, Shin Enosawa, Kuang-Ming Shang, Hirotake Komatsu   +4 more
doaj   +1 more source

Bioluminescent imaging of Trypanosoma cruzi infection in Rhodnius prolixus

Parasites & Vectors, 2012
Background Usually the analysis of the various developmental stages of Trypanosoma cruzi in the experimentally infected vertebrate and invertebrate hosts is based on the morphological observations of tissue fragments from animals and insects.
Henriques Cristina, Castro Daniele P, Gomes Leonardo HF, Garcia Eloi S, de Souza Wanderley   +4 more
doaj   +1 more source

Mesenchymal Stem Cells From a Klinefelter Syndrome Patient: Functional Characterization and Therapeutic Implications

Andrology, EarlyView.
ABSTRACT Background Cell therapy, particularly those utilizing mesenchymal stem/stromal cells (MSCs), is gaining traction as a therapeutic option for regenerative treatment in patients with limited therapeutic options. Although the safety of MSC‐based interventions is well established, uncertainties remain regarding how genetic abnormalities and ...
Marzena Zychowicz, Wioletta Lech, Anna Figiel‐Dabrowska, Marta Kot, Magdalena Murzyn, Natalia Malawska, Barbara Pienkowska‐Grela, Zuzanna Sandowska‐Markiewicz, Iwona Ziolkowska‐Suchanek, Agnieszka Zimna, Tomasz Oldak, Natalia Rozwadowska, Anna Sarnowska   +12 more
wiley   +1 more source

Mechanistic model for the firefly luciferin regeneration in biomimetic conditions: a model for the in vivo process?

, 2017
Firefly luciferin is recycled backin vivoby 2-cyano-6-hydroxybenzothiazole coupling with cysteine in a complex multi-step process involving specific base catalysis.
Lucas S. Sgarbi, Luiz F. M. L. Ciscato, Diêgo U. Melo, Carla T. Salatino, Paula Homem-de-Mello, Ariane M. Yoshitake, Fernando H. Bartoloni   +6 more
core   +1 more source

Design and Synthesis of an Alkynyl Luciferin Analogue for Bioluminescence Imaging [PDF]

, 2016
Herein, the synthesis and characterization of an alkyne-modified luciferin is reported. This bioluminescent probe was accessed using C-H activation methodology and was found to be stable in solution and capable of light production with firefly luciferase.
Steinhardt, Rachel C, Rathbun, Colin M, Paley, Miranda A, O'Neill, Jessica M, McCutcheon, David C, Prescher, Jennifer A   +5 more
core   +1 more source

In vivo imaging of mice infected with bioluminescent Trypanosoma cruzi unveils novel sites of infection

Parasites & Vectors, 2014
Background The development of techniques that allow the imaging of animals infected with parasites expressing luciferase opens up new possibilities for following the fate of parasites in infected mammals. Methods D-luciferin potassium salt stock solution
Cristina Henriques, Andréa Henriques-Pons, Marcelo Meuser-Batista, Aline Salgado Ribeiro, Wanderley de Souza   +4 more
doaj   +1 more source

The IKU2/RLK7–MAPK–MINI3 signaling module controls endosperm cellularization timing to determine seed size in Arabidopsis

Journal of Integrative Plant Biology, EarlyView.
The phosphorylation status of the WRKY transcription factor WRKY10/MINI3, controls the timing of endosperm cellularization in Arabiopsis, thus regulating final seed size, offering a molecular understanding that could inform future agricultural breeding strategies. ABSTRACT Seed size is a critical factor in determining crop yield.
Min Ni, Yuchen Qian, Tinggang Nong, Wangshu Mou, Niu Liu, La Yang, Dongdong Li, Huixia Shou, Juan Xu   +8 more
wiley   +1 more source