Results 71 to 80 of about 21,179 (270)

Synthesis and Luminescence Properties of Near-Infrared N-Heterocyclic Luciferin Analogues for In Vivo Optical Imaging [PDF]

, 2019
As a means of achieving highly sensitive bioluminescence imaging of deep tissues utilizing the firefly luciferin-luciferase (L-L) reaction, we previously reported a luciferin analogue, AkaLumine, which exhibits high cell-permeability and emits near ...
Masahiro Kiyama, Rika Obata, Ryohei Saito, Satoshi Iwano, Shijia W. Lu, Shinae Kizaka-Kondoh, Shojiro A. Maki, Shoko Higashi, Takahiro Kuchimaru, Takashi Hirano   +9 more
core   +2 more sources

Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion

Advanced Science, EarlyView.
The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li, Yuanxin Li, Asif Rashid, Hong Kee Tan, Shing Chan, Man Yan Hui, Wilson Yau Ki Chan, Kee See Lam, Yinping Liu, Wenwei Tu, Wing Leung   +10 more
wiley   +1 more source

Rapid, quantitative determination of bacteria in water [PDF]

, 1978
A bioluminescent assay for ATP in water borne bacteria is made by adding nitric acid to a water sample with concentrated bacteria to rupture the bacterial cells.
Chappelle, E. W., Deming, J. W., Jeffers, E. L., Picciolo, G. L., Thomas, R. R.   +4 more
core   +1 more source

In Vivo CRISPR Screening Identifies the Glutamate Receptor GRIA2 as Promoting Peritoneal Metastasis of Gastric Cancer via Calcium‐Dependent β‐Catenin Activation

Advanced Science, EarlyView.
We identified GRIA2 as a critical driver of gastric cancer peritoneal metastasis through in vivo CRISPR screening. Mechanistically, GRIA2‐mediated calcium influx inhibits GSK3β and activates Wnt/β‐catenin signaling, driven by glutamate from cancer‐associated fibroblasts.
Jie Sun, Xu Yang, Wenchao Jiang, Chengbo Ji, Yingying Wu, Haoyu Sun, Xinyou Liu, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Junjie Zhao, Yuanyuan Ruan, Haojie Li, Xuefei Wang   +13 more
wiley   +1 more source

Suppression of tumour growth from transplanted astrocytoma cells transfected with luciferase in mice by bioluminescence mediated, systemic, photodynamic therapy

Photodiagnosis and Photodynamic Therapy
Background: Grade 4 astrocytomas are usually incurable due to their diffusely infiltrative nature. Photodynamic therapy (PDT) is a promising therapeutic option, but external light delivery is impractical when cancer cells infiltrate unknown areas of ...
Jane Ng, Nico Henriquez, Neil Kitchen, Norman Williams, Marco Novelli, Dahmane Oukrif, Alexander MacRobert, Stephen Bown   +7 more
doaj   +1 more source

Giardia Colonizes and Encysts in High-Density Foci in the Murine Small Intestine. [PDF]

, 2017
Giardia lamblia is a highly prevalent yet understudied protistan parasite causing significant diarrheal disease worldwide. Hosts ingest Giardia cysts from contaminated sources.
Barash, NR, Dawson, SC, Gourguechon, S, McCarthy-Sinclair, B, McInally, SG, Nosala, C, Pham, JK   +6 more
core  

Regression of experimental NIS-expressing breast cancer brain metastases in response to radioiodide/gemcitabine dual therapy. [PDF]

, 2016
Treating breast cancer brain metastases (BCBMs) is challenging. Na+/I- symporter (NIS) expression in BCBMs would permit their selective targeting with radioiodide (131I-).
Ahmad, Ahn, Carlson, Carrasco, Carrasco, Carrasco, Carrasco, Carrasco, Clarke, Desai, Dirbas, Dominguez, Gambhir, Gonzalez-Angulo, Grollman, Harrington, Haveman, Ikeda, Jhiang, Jhiang, Jhiang, Kalkanis, Kang, Kirova, Lawrence, Lawrence, Lind, Link, Liu, Lorusso, Mier, Morris, Neuwelt, Nishimura, Russell, Schlumberger, Seidman, Smith, Spitzweg, Steeg, Studebaker, Vermorken, Vermorken, Wapnir, Wapnir, Wapnir, Wapnir   +46 more
core   +1 more source

Transdermal Delivery of an mRNA‐Liposome Vaccine via Dissolving Microneedle to Preserve Vaccine Activity and Enhance Immune Activation

Advanced Science, EarlyView.
An mRNA‐liposome vaccine via dissolving microneedles (ML‐DMN) enables efficient skin‐targeted delivery while preserving mRNA integrity and allowing sustained antigen expression. Unlike intramuscular (IM) injection, ML‐DMN engages skin‐resident immune cells, activates antigen‐presenting cells (APCs), and induces strong T cell and cytokine responses at ...
Jeehye Nam, JiWon Ahn, Jiwoo Shin, Nahong Lee, Youjin Lee, Sung min Cho, Paul Kim, Geonwoo Kang, Sang‐Jun Ha, Hyungil Jung   +9 more
wiley   +1 more source

Firefly Rats: Illuminating the Scientific Community in Transplantation Research

Cell Transplantation
Fireflies produce light through luciferase-catalyzed reactions involving luciferin, oxygen, and adenosine triphosphate, distinct from other luminescent organisms.
Eiji Kobayashi, Yoji Hakamata, Shin Enosawa, Kuang-Ming Shang, Hirotake Komatsu   +4 more
doaj   +1 more source

Bioluminescent imaging of Trypanosoma cruzi infection in Rhodnius prolixus

Parasites & Vectors, 2012
Background Usually the analysis of the various developmental stages of Trypanosoma cruzi in the experimentally infected vertebrate and invertebrate hosts is based on the morphological observations of tissue fragments from animals and insects.
Henriques Cristina, Castro Daniele P, Gomes Leonardo HF, Garcia Eloi S, de Souza Wanderley   +4 more
doaj   +1 more source