Results 91 to 100 of about 17,850,316 (257)

Standardized incidence ratios (SIRS) of VTE among first-degree relatives.

, 2016
Relative rate of VTE among first-degree relatives to patients with VTE. The reference is the general population. CI = confidence interval. *Adjusted for age, sex and calendar year.
Gunnar Gislason (324410), Jonas Bjerring Olesen (354233), Anna Gundlund (3608114), Emil Loldrup Fosbøl (3608108), Christian Torp-Pedersen (103282), Louise Bruun Oestergaard (3608105), Kristian Aasbjerg (3608111), Jannik Langtved Pallisgaard (819722), Caroline Sindet-Pedersen (3079869)   +8 more
core   +1 more source

Role of tumour molecular and pathology features to estimate colorectal cancer risk for first-degree relatives [PDF]

, 2014
Objective: To estimate risk of colorectal cancer (CRC) for first-degree relatives of CRC cases based on CRC molecular subtypes and tumour pathology ...
Dite, Gillian S., Lindor, Noralane M., Walsh, Michael D, Giles, Graham G., Thibodeau, Stephen N., Jenkins, Mark A., Hopper, John L., Buchanan, Daniel D., Newcomb, Polly A., Potter, John D, Smyrk, Thomas C, Buchanan, Daniel D, Dite, Gillian S, Clendenning, Mark, Dowty, James G, Southey, Melissa C, Gallinger, Steven, Jenkins, Mark A, Dowty, James G., Gallinger, Stephen, Thibodeau, Stephen N, Hopper, John L, Ahnen, Dennis J, Young, Joanne P, Ahnen, Dennis J., Potter, John D., Le Marchand, Loic, Baron, John A., Giles, Graham G, Boussioutas, Alex, MacInnis, Robert J, Baron, John A, Newcomb, Polly A, Walters, Rhiannon J., Smyrk, Thomas C., Lindor, Noralane M, Southey, Melissa C., Rosty, Christophe, Walsh, Michael D., Haile, Robert W., Win, Aung Ko, MacInnis, Robert J., Young, Joanne P., Haile, Robert W, Walters, Rhiannon J   +44 more
core   +1 more source

Brain atrophy rates in first degree relatives at risk for Alzheimer's

NeuroImage: Clinical, 2014
A positive family history (FH) raises the risk for late-onset Alzheimer's disease though, other than the known risk conferred by apolipoprotein ε4 (ApoE4), much of the genetic variance remains unexplained.
Erika J. Lampert, Kingshuk Roy Choudhury, Christopher A. Hostage, Bharath Rathakrishnan, Michael Weiner, Jeffrey R. Petrella, P. Murali Doraiswamy   +6 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

PREVALENCE OF LIVER FIBROSIS IN RELATIVES OF PATIENTS WITH MASLD-RELATED CIRRHOSIS: A STUDY ON DEGREE OF KINSHIP

Annals of Hepatology
Introduction and Objectives: First-degree relatives of patients with MASLD-related cirrhosis are considered at high risk for liver fibrosis, based on evidence from Europe and the U.S.
Ismael de Jesús Yepes Barreto, Nicole Chamorro, Guillermo Donado   +2 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Ischaemic heart disease in first-degree relatives to coeliac patients

, 2014
ObjectiveCoeliac disease (CD) has been linked to an increased risk of ischaemic heart disease (IHD). We examined the risk of IHD in first-degree relatives and spouses to coeliac patients to ascertain the genetic contribution to IHD excess risk.
Emilsson, Louise, Emilsson, Louise,, Ludvigsson, Jonas F., James, Stefan,, Ludvigsson, JF, James, S, Ludvigsson, Jonas F.,, James, Stefan K.,, Emilsson, L,   +8 more
core   +1 more source

Verbal fluency and working memory deficit in first-degree relatives of autistic children

مجله دانشگاه علوم پزشکی گرگان, 2012
Background and Objective: Autism spectrum disorder is a genetic-based cognitive and neurobehavioral disorder characterized by impairment in social interaction, verbal and non-verbal communication and repetitive motor behavior.
Nejati V, Izadi-Najafabadi S
doaj  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source