Results 111 to 120 of about 17,850,316 (257)

The microbiome in human skin aging

open access: yesFEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana   +3 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

Psychiatric Disorders in First-Degree Relatives of Patients with Opiate Dependence

open access: yes, 1999
High rates of psychiatric disorders, particularly major depression, alcoholism, drug-use disorder and antisocial personality disorder in the relatives of opiate-dependent patients compared with normal controls, have been reported in some previous ...
Emad Salib, A. G. Ahmed, Sue Ruben
core   +1 more source

Premorbid IQ in patients with functional psychosis and their first-degree relatives

open access: yes, 2000
Numerous studies have found deficits in premorbid IQ in schizophrenic patients, but it is not clear whether this deficit is shared by (a) patients with other functional psychoses, and (b) relatives of these patients. Ninety-one schizophrenic patients, 66
Gilvarry, C   +5 more
core   +3 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Intestinal permeability in patients with Crohn's disease and ulcerative colitis and their first degree relatives

open access: yes, 1994
Increased intestinal permeability in patients with Crohn's disease and their first degree relatives has been proposed as an aetiological factor. The nine hour overnight urinary excretion of polyethyleneglycol-400 (PEG-400) and three inert sugars ...
Hollander, D   +6 more
core   +1 more source

Co-Morbid Medical Disorders in First Degree Relatives of Probands With Bipolar Mood Disorder

open access: yesJournal of Rawalpindi Medical College, 2016
Background: To determine the frequency of co morbid medical disorders in the first degree relatives(FDRs) of probands with bipolar mood disorder. Methods: In this descriptive study one hundred bipolar probands were consecutively recruited using ICD-10 ...
Asif Kamal
doaj  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Mental Health Locus of Control in First-Degree Relatives of Agoraphobic and Depressed Inpatients

open access: yes, 1992
Mental health locus of control in 77 first-degree relatives of agoraphobic, agoraphobic and major depressed (comorbid), and depressed inpatients were studied. Relatives of comorbid patients externalized locus of control more to chance than did relatives
Asle Hoffart, Svenn Torgersen
core   +1 more source

Research progress on the decisional conflict of cancer screening for first⁃degree relatives of cancer patients

open access: yesHuli yanjiu
This article reviewed the current situation of the decisional conflict in cancer screening for first⁃degree relatives of cancer patients.It summarized the influence of factors such as individuals,medical care,social support and health literacy,disease ...
ZHANG Jiawei   +3 more
doaj  

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