Results 101 to 110 of about 17,850,316 (257)

Otosclerosis among first and second degree Relatives of Otosclerotic patients

Journal of Research in Medical Sciences, 2006
Background: Otosclerosis (OS) is the most common cause of conductive hearing loss in young population, and we determined incidence of OS among 1st and 2 nd degree relatives of surgically proved otosclerotic patients. Methods: In a cross sectional ...
S Soheilipour, S Nemati
doaj  

Familial aggregation of first degree relatives of children with essential hypertension

Blood Pressure, 2018
Purpose: Determining familial aggregation is an important first step in narrowing the search for disease-causing genes and hence we determined the familial aggregation of EH among first degree relatives of children with EH.
Monesha Gupta-Malhotra, Syed Shahrukh Hashmi, Michelle S. Barratt, Dianna M. Milewicz, Sanjay Shete   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Screening first-degree relatives of patients with Chronic Kidney Disease (CKD) in Pakistan

Journal of the Pakistan Medical Association
Dear Sir / Madam Chronic Kidney Disease (CKD) poses a worldwide health concern, affecting more than eight hundred million people globally, with underdeveloped nations sharing the greatest disease burden.1 It’s hypothesised that by 2030, countries with
Amna Ilyas, Bakhtawar Ali
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Gastric mucosa alterations in first-degree relatives of gastric cancer patients

, 2005
First-degree relatives of gastric cancer patients have an increased risk of developing such neoplasia, and several alterations in gastric mucosa of these subjects have been described.
I. Sarcina, E. Ierardi, IERARDI, ENZO GIANNI, VECCHIONE, Aldo, A. ROMITI, ROMITI, ADRIANA, C. Hassan, TOMAO, SILVERIO, A. Zullo, V. De Francesco, Romiti, Anita, TOMAO, FEDERICA, S. TOMAO, Hassan, Cesare, S. Morini, A. VECCHIONE   +15 more
core  

Increased risk of essential tremor in first-degree relatives of patients with Parkinson's disease.

, 2007
International audienceWe conducted a historical cohort study of 981 first-degree relatives of 162 patients with Parkinson's disease (PD) and of 838 first-degree relatives of 147 controls representative of the population of Olmsted County, Minnesota.
Ahlskog, J. Eric, Grossardt, Brandon, R., Bower, James, H., Elbaz, Alexis, Mcdonnell, Shannon, K., Schaid, Daniel, J., Maraganore, Demetrius, M., Rocca, Walter, A., Maraganore, Demetrius,, Walter A. Rocca, Daniel J. Schaid, James H. Bower, J. Eric Ahlskog, Mcdonnell, Shannon,, Bower, James,, Rocca, Walter,, Brandon R. Grossardt, Schaid, Daniel,, Demetrius M. Maraganore, Alexis Elbaz, Shannon K. McDonnell, Grossardt, Brandon,   +21 more
core   +1 more source

Cardiovascular risk and subclinical atherosclerosis in first-degree relatives of patients with premature cardiovascular disease

American Journal of Preventive Cardiology
Background: Screening first-degree relatives (FDRs) of patients with premature coronary artery disease (CAD) is recommended but not routinely performed.
Diana N. Vikulova, Danielle Pinheiro-Muller, Gordon Francis, Frank Halperin, Tara Sedlak, Keith Walley, Christopher Fordyce, GB John Mancini, Simon N. Pimstone, Liam R. Brunham   +9 more
doaj   +1 more source