Results 91 to 100 of about 14,644,227 (324)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Recent biocontrol measures for fish bacterial diseases, in particular to probiotics, bio-encapsulated vaccines, and phage therapy

Open Veterinary Journal, 2019
The objective of this review is to control fish bacterial diseases or infections through application of some promising novel biocontrol methods, such as probiotics, bio-encapsulated vaccines, and phage therapy, to avoid the disadvantages of traditional ...
W. Soliman, R. Shaapan, L. Mohamed, Samira S.R. Gayed   +3 more
semanticscholar   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

First field evidence of aerosolised SGPV, ISAV-HPR0, and IPNV in Atlantic salmon RAS highlights transmission and biosecurity risks

Scientific Reports
Recirculating aquaculture systems (RAS) for Atlantic salmon (Salmo salar L.) are closed-containment systems (CCS) offering biosecure, water-efficient farming conditions, yet pathogen transmission remains a critical concern.
Dhiraj Krishna, Petra Elisabeth Petersen, Maria Marjunardóttir Dahl, Ingibjørg Egholm, Debes Hammershaimb Christiansen   +4 more
doaj   +1 more source

Myxozoan fish diseases: possible treatment and zoonoses. [PDF]

J Parasit Dis, 2023
Banu H, Rathinam RB.
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Immune response of sharpsnout seabream (Diplodus puntazzo, Cetti 1777) to Enteromyxum leei.

, 2007
E. leei affects at least 25 fish species but it represents a production limiting factor most of all for sharpnout seabream, causing high mortality during the first year of rearing (Diamant, 1995; Athanassopoulou et al., 1999). The knowledge on the immune
VOLPATTI, Donatella, D. Volpatti, B. CONTESSI, M. Galeotti, F. BASILE, C. Bulfon, GALEOTTI, Marco, BERALDO, Paola, FIORAVANTI, MARIALETIZIA, P. Beraldo, CONTESSI, Barbara, M. L. FIORAVANTI, BULFON, Chiara   +12 more
core   +1 more source

Viral diseases of fish in Japan

Annual Review of Fish Diseases, 1991
Viruses causing infectious pancreatic necrosis (IPN) and infectious hematopoietic necrosis (IHN) were first isolated in Japan during the 1970s and these two diseases remain among the most serious problems affecting cultured salmonids in Japan. In addition to IHN and IPN, four other viral diseases cause major economic losses among cultured fishes in ...
Kimura, Takahisa, Yoshimizu, Mamoru
openaire   +2 more sources

Transcriptome Analysis Based on RNA-Seq in Understanding Pathogenic Mechanisms of Diseases and the Immune System of Fish: A Comprehensive Review

International Journal of Molecular Sciences, 2018
In recent years, with the advent of next-generation sequencing along with the development of various bioinformatics tools, RNA sequencing (RNA-Seq)-based transcriptome analysis has become much more affordable in the field of biological research.
Arun Sudhagar, G. Kumar, M. El-Matbouli
semanticscholar   +1 more source

National fish, wildlife and plants climate adaptation strategy

, 2013
The purpose of the National Fish, Wildlife and Plants Climate Adaptation Strategy is to inspire and enable natural resource administrators, elected officials, and other decision makers to take action to adapt to a changing climate.
National Fish, Wildlife and Plants Climate adaptation Partnership
core