Results 71 to 80 of about 14,644,227 (324)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Effects of Different Diets on Growth Performance and Nutritional Composition of Blue Crab (Callinectes sapidus, Rathbun, 1896) in a Recirculating Aquaculture System

Animals
This study evaluated the effects of three feeding regimens—commercial feed (CF), minced trash fish (MTF), and a 50:50 mixture (MIX)—on the growth performance and tissue composition of the blue crab (Callinectes sapidus) reared in a recirculating ...
Deniz Devrim Tosun, Güneş Yamaner, Mustafa Yıldız, Şehnaz Yasemin Tosun, Menekşe Didem Demircan Akyasan, Ömer Metin, Eylül Balcıoğlu   +6 more
doaj   +1 more source

First report of Lernaea cyprinacea (Crustacea: Lernaeidae) parasiting Rhamdia quelen (Pisces: Heptapteridae) in Santa Fe (Argentina) under hatchery conditions

Revista Colombiana de Ciencias Pecuarias, 2018
Background: Lernaea cyprinacea was introduced in South America with cyprinids. To the best of our knowledge, this ectoparasite has not been reported in Santa Fe province (Argentina).
Silvia H. Gervasoni, Silvina B. Chemes, María Cristina Scaglione, Raúlk D. Cerutti   +3 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Consumption of fish and Alzheimer's Disease [PDF]

The Journal of nutrition, health and aging, 2011
Alzheimer's Disease (AD) has been described as "one of the most disabling and burdensome health conditions worldwide" and is responsible for approximately 70% of dementia in the elderly. Based on the current prevalence of AD, an aging world population and the associated projected health care requirements, it is estimated that by 2050, the prevalence of
Newton, Wendy, McManus, Alexandra
openaire   +3 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

THE CURRENT METHODS FOR MOLECULAR DIAGNOSTICS OF FISH DISEASES (REVIEW)

Ribogospodarsʹka Nauka Ukraïni, 2016
Purpose. The methods of molecular diagnostic (MMD) gradually become widespread in modern fish farming. MMD contain a wide variety of specific approaches, each of which has distinct limits of their possible applications and is characterized by individual ...
O. Zaloilo, Yu. Rud, I. Zaloilo, І. Hrytsyniak   +3 more
doaj   +1 more source

Studies on the Effects of Enrofloxacin Overdose on Different Health Parameters in Broiler Chickens [PDF]

Journal of Veterinary Medical Research, 2008
The effect of 10 times (10x) overdose of enrofloxacin was studied in broiler chickens. One hundred and eighty chicks were classified in 3 equal groups. The first group received normal theurapeutic dose of enrofloxacin (1x) in drinking water for the first
H.F. Ellakany, I.M. Abu El-Azm, A.A. Bekhit, M.M. Shehawy   +3 more
doaj   +1 more source