Results 71 to 80 of about 3,325,822 (291)

Fish oils and cardiovascular disease [PDF]

BMJ, 1995
EDITOR,—In their editorial B N C Pritchard and colleagues concluded that fish oils have beneficial effects on lipids and the haemostatic system, but they pressed for more studies in diseases related to atherosclerosis.1 We wish to reinforce this …
A, Haines, J S, Yudkin
openaire   +2 more sources

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Immune response of sharpsnout seabream (Diplodus puntazzo, Cetti 1777) to Enteromyxum leei.

, 2007
E. leei affects at least 25 fish species but it represents a production limiting factor most of all for sharpnout seabream, causing high mortality during the first year of rearing (Diamant, 1995; Athanassopoulou et al., 1999). The knowledge on the immune
VOLPATTI, Donatella, D. Volpatti, B. CONTESSI, M. Galeotti, F. BASILE, C. Bulfon, GALEOTTI, Marco, BERALDO, Paola, FIORAVANTI, MARIALETIZIA, P. Beraldo, CONTESSI, Barbara, M. L. FIORAVANTI, BULFON, Chiara   +12 more
core   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Occurrence of virulence factors and antimicrobial susceptibility of Citrobacter freundii isolated from diseased ornamental fish in Poland

Journal of Veterinary Research
Citrobacter freundii strains, like other representatives of the same genus, are often described as aetiological factors of diseases in humans and animals, including farmed and ornamental fish.
Pastuszka Anna, Guz Leszek, Puk Krzysztof, Pietras-Ożga Dorota   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

First field evidence of aerosolised SGPV, ISAV-HPR0, and IPNV in Atlantic salmon RAS highlights transmission and biosecurity risks

Scientific Reports
Recirculating aquaculture systems (RAS) for Atlantic salmon (Salmo salar L.) are closed-containment systems (CCS) offering biosecure, water-efficient farming conditions, yet pathogen transmission remains a critical concern.
Dhiraj Krishna, Petra Elisabeth Petersen, Maria Marjunardóttir Dahl, Ingibjørg Egholm, Debes Hammershaimb Christiansen   +4 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Open workshop: Bottlenecks in diagnostics of Mediterranean fish diseases

, 2019
The goal of two EU funded projects in the frame of Horizon 2020, namely MedAID and PerformFISH, is to increase the overall competitiveness and sustainability of the Mediterranean marine fish-farming sector, throughout the whole value chain.
Gustinelli, Andrea, Palenzuela, Oswaldo, Zrnčić, Snježana, Brun, Edgar, Padros, Francesc, Fioravanti, Marialetizia   +5 more
core