Results 191 to 200 of about 46,672 (263)

Therapeutic access points: The roles of circumventricular organs in drug delivery and metabolic regulation

open access: yesBritish Journal of Pharmacology, EarlyView.
The current obesity drug landscape, dominated by GLP‐1 receptor agonists and emerging multi‐agonist therapies, has reinforced that long‐term weight loss is achieved in large part through central mechanisms that suppress appetite and reshape energy balance.
Ines Martinez‐Corral   +3 more
wiley   +1 more source

High Specificity of sIgE to α−/β‐Gliadin and Limited Reactivity to Non‐Gluten Proteins in Wheat Allergy Dependent on Augmentation Factors (WALDA)

open access: yesClinical &Experimental Allergy, EarlyView.
This study suggest that WALDA is characterized by highly specific reactivity to gliadin proteins, with limited sensitization to non‐gluten wheat components. sIgE to α‐/β‐gliadin represents a promising diagnostic biomarker with superior specificity compared to ω5‐gliadin alone.
Valentina Faihs   +7 more
wiley   +1 more source

Navigating the Activist Techno‐Social Landscape: Washington, DC High School Students' Engagement with Social Media Content

open access: yesChildren &Society, EarlyView.
ABSTRACT In recent decades, youth activism has experienced a global resurgence, playing a pivotal role in advocating for social and political change across diverse national and international contexts. Drawing on empirical data from a study of high school students in diverse Washington, DC public schools, this paper offers a unique perspective on youth ...
Vanessa R. Sperduti   +3 more
wiley   +1 more source

Frontline Healthcare Professionals' Perceptions of the Duty to Care During the COVID‐19 Pandemic: A Multi‐Method Study in Mozambique

open access: yesDeveloping World Bioethics, EarlyView.
ABSTRACT COVID‐19 intensified ethical tensions between clinicians' duty to care and self‐protection amid PPE shortages. We explored frontline healthcare professionals' perspectives in Maputo, Mozambique. Semi‐structured interviews with healthcare professionals at four hospitals (April–June 2022) were recorded in Portuguese, transcribed, and ...
Ângela Alface   +5 more
wiley   +1 more source

Disentangling the effect of brain insulin resistance on brain health (BIR‐BrainHealth): Rationale and study protocol

open access: yesDiabetic Medicine, EarlyView.
Abstract Aims Insulin signalling in the brain is crucial for systemic metabolic regulation and cognitive function. In some individuals, these effects are reduced, a phenomenon referred to as brain insulin resistance (BIR). This condition may contribute to the elevated risk of cognitive decline and dementia in diabetes, yet its prevalence, mechanisms ...
Sabrina Wangler   +11 more
wiley   +1 more source

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