Results 41 to 50 of about 859,212 (311)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Features of pollock fishing technology

open access: yesTrudy VNIRO, 2022
The purpose of the work is to study the features of specialized pollock fishing in the North Pacific Ocean.Identification of ways to increase the selectivity of specialized pollock fishing.Methods used: features of specialized pollock fishing in the North Pacific Ocean were investigated by analyzing regulatory documents governing fishing in Russia, the
S. E. Astafiev   +4 more
openaire   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Micro/Nano Bubble Technology : Characteristics and Implications Biology Performance of Koi Cyprinus carpio in Recirculation Aquaculture System (RAS)

open access: yesOmni-Akuatika, 2018
Technology for aquaculture is growing with the high demand of fish. Micro / nano bubble is one of technology that is developed to increase dissolved oxygen in water. This technology is used to increase Koi fish production in high density via RAS.
Henry Kasmanhadi Saputra   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Effect of Glycation Reaction on Volatile Flavor and Gel Properties of Fish Protein Gelatin

open access: yesShipin gongye ke-ji
To improve the flavor of fish protein gelatin, the glycation reaction system was constructed with glucose, and use microplate readers, colorimeters, texture analyzers, rheometers, and gas chromatography-mass spectrometers were used to determine the free ...
Fenfen WU   +5 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

High Seas Fisheries Management Gets Low Marks [PDF]

open access: yes, 2010
Fishing on the high seas—areas beyond the 200-nautical-mile jurisdiction of coastal states—is increasing, largely driven by advanced vessel and gear technology, which facilitates fishing far from shore.
Daniel Pauly, Sarika Cullis-Suzuki
core  

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

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