The WD40 protein Caf4p is a component of the mitochondrial fission machinery and recruits Dnm1p to mitochondria [PDF]
The mitochondrial division machinery regulates mitochondrial dynamics and consists of Fis1p, Mdv1p, and Dnm1p. Mitochondrial division relies on the recruitment of the dynamin-related protein Dnm1p to mitochondria.
Chan, David C.+2 more
core +3 more sources
Cell-cycle regulated transcription associates with DNA replication timing in yeast and human [PDF]
Eukaryotic DNA replication follows a specific temporal program, with some genomic regions consistently replicating earlier than others, yet what determines this program is largely unknown.
Fraser, Hunter B.
core +1 more source
Checkpoint-Dependent Regulation of Origin Firing and Replication Fork Movement in Response to DNA Damage in Fission Yeast [PDF]
To elucidate the checkpoint mechanism responsible for slowing passage through S phase when fission yeast cells are treated with the DNA-damaging agent methyl methanesulfonate (MMS), we carried out two-dimensional gel analyses of replication intermediates
Huberman, Joel A., Kumar, Sanjay
core +3 more sources
Structural basis for recruitment of mitochondrial fission complexes by Fis1 [PDF]
Mitochondrial fission controls mitochondrial shape and physiology, including mitochondrial remodeling in apoptosis. During assembly of the yeast mitochondrial fission complex, the outer membrane protein Fis1 recruits the dynamin-related GTPase Dnm1 to ...
Abdelwahid+16 more
core +3 more sources
Latrunculin A delays anaphase onset in fission yeast by disrupting an ase1-independent pathway controlling mitotic spindle stability [PDF]
It has been proposed previously that latrunculin A, an inhibitor of actin polymerization, delays the onset of anaphase by causing spindle misorientation in fission yeast.
Meadows, John C., Millar, Jonathan B. A.
core +2 more sources
Fission yeast: in shape to divide
How are cell morphogenesis and cell cycle coordinated? The fission yeast is a rod-shaped unicellular organism widely used to study how a cell self-organizes in space and time. Here, we discuss recent advances in understanding how the cell acquires and maintains its regular rod shape and uses it to control cell division.
Olivier Hachet+2 more
openaire +3 more sources
The bistable mitotic switch in fission yeast [PDF]
In favorable conditions, eukaryotic cells proceed irreversibly through the cell division cycle (G1-S-G2-M) in order to produce two daughter cells with the same number and identity of chromosomes of their progenitor. The integrity of this process is maintained by “checkpoints” that hold a cell at particular transition points of the cycle until all ...
Novák B, Tyson JJ.
europepmc +4 more sources
Formins Determine the Functional Properties of Actin Filaments in Yeast [PDF]
The actin cytoskeleton executes a broad range of essential functions within a living cell. The dynamic nature of the actin polymer is modulated to facilitate specific cellular processes at discrete locations by actin-binding proteins (ABPs), including ...
Balasubramanian+29 more
core +1 more source
Meiotic recombination proteins localize to linear elements in Schizosaccharomyces pombe [PDF]
Peer ...
Estreicher, A.+3 more
core +1 more source
Identification of a novel type of spacer element required for imprinting in fission yeast [PDF]
Asymmetrical segregation of differentiated sister chromatids is thought to be important for cellular differentiation in higher eukaryotes. Similarly, in fission yeast, cellular differentiation involves the asymmetrical segregation of a chromosomal ...
A Kaykov+47 more
core +7 more sources