Results 31 to 40 of about 84,111 (254)
Parkinson's Disease, 2011 In Parkinson's disease (PD), misfolded and aggregated α-synuclein protein accumulates in degenerating midbrain dopaminergic neurons. The amino acid alanine-76 in α-synuclein and phosphorylation at serine-87 and serine-129 are thought to regulate its ...
Michael Fiske +8 more
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eLife, 2019 Conserved proteins drive clathrin-mediated endocytosis (CME), which from yeast to humans involves a burst of actin assembly. To gain mechanistic insights into this process, we performed a side-by-side quantitative comparison of CME in two distantly ...
Yidi Sun +7 more
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Eic1 links Mis18 with the CCAN/Mis6/Ctf19 complex to promote CENP-A assembly [PDF]
Open Biology, 2014 CENP-A chromatin forms the foundation for kinetochore assembly. Replication-independent incorporation of CENP-A at centromeres depends on its chaperone HJURPScm3, and Mis18 in vertebrates and fission yeast.
Lakxmi Subramanian +3 more
doaj +1 more source
eLife, 2021 Mammalian target of rapamycin complex 1 (TORC1) is controlled by the GATOR complex composed of the GATOR1 subcomplex and its inhibitor, the GATOR2 subcomplex, sensitive to amino acid starvation.
Tomoyuki Fukuda +9 more
doaj +1 more source
The WD40 protein Caf4p is a component of the mitochondrial fission machinery and recruits Dnm1p to mitochondria [PDF]
, 2005 The mitochondrial division machinery regulates mitochondrial dynamics and consists of Fis1p, Mdv1p, and Dnm1p. Mitochondrial division relies on the recruitment of the dynamin-related protein Dnm1p to mitochondria.
Chan, David C. +2 more
core +3 more sources
DNA checkpoints in fission yeast [PDF]
Journal of Cell Science, 2003 The DNA integrity checkpoints ensure completion of DNA replication and DNA repair before entry into mitosis ([O'Connell et al., 2000][1]). Unreplicated DNA or unrepaired DNA will cause catastrophic chromosome segregation.
Kanji, Furuya, Antony M, Carr
openaire +2 more sources
How to halve ploidy : lessons from budding yeast meiosis [PDF]
, 2012 Maintenance of ploidy in sexually reproducing organisms requires a specialized form of cell division called meiosis that generates genetically diverse haploid gametes from diploid germ cells.
Arumugam, Prakash +2 more
core +1 more source
Fission yeast goes synthetic [PDF]
Nature Methods, 2007 A high-throughput procedure for genome-wide identification of genetic interactions in Schizosaccharomyces pombe.
openaire +2 more sources
A Cloning-Free Method for CRISPR/Cas9-Mediated Genome Editing in Fission Yeast
G3: Genes, Genomes, Genetics, 2018 The CRISPR/Cas9 system, which relies on RNA‐guided DNA cleavage to induce site-specific DNA double-strand breaks, is a powerful tool for genome editing.
Xiao-Ran Zhang +3 more
doaj +1 more source
Rad62 protein functionally and physically associates with the Smc5/Smc6 protein complex and is required for chromosome integrity and recombination repair in fission yeast [PDF]
, 2004 Smc5 and Smc6 proteins form a heterodimeric SMC (structural maintenance of chromosome) protein complex like SMC1-SMC3 cohesin and SMC2-SMC4 condensin, and they associate with non-SMC proteins Nse1 and Nse2 stably and Rad60 transiently.
Carr, Antony +5 more
core +2 more sources