iScience, 2023 Summary: Non-muscle myosin II activation by regulatory light chain (Rlc1Sp) phosphorylation at Ser35 is crucial for cytokinesis during respiration in the fission yeast Schizosaccharomyces pombe.
Francisco Prieto-Ruiz +6 more
doaj +1 more source
Reversal of metformin's anti-proliferative effect in fission yeast efr3 and dnm1 (DRP1) mutants with elongated mitochondria. [PDF]
NPJ Metab Health DisGillespie A +9 more
europepmc +3 more sources
Spd2 assists Spd1 in modulation of RNR architecture but does not regulate deoxynucleotide pools [PDF]
, 2014 In yeasts, small intrinsically disordered proteins (IDPs) modulate ribonucleotide reductase (RNR) activity to ensure an optimal supply of dNTPs for DNA synthesis. The S. pombe Spd1 protein can directly inhibit the large RNR subunit (R1), import the small
Basrai +37 more
core +1 more source
PathogensFission yeast, a single-cell eukaryotic organism, shares many fundamental cellular processes with higher eukaryotes, including gene transcription and regulation, cell cycle regulation, vesicular transport and membrane trafficking, and cell death ...
Jiantao Zhang +3 more
doaj +1 more source
A comparative analysis of telomere length maintenance circuits in fission and budding yeast
Frontiers in Genetics, 2022 The natural ends of the linear eukaryotic chromosomes are protected by telomeres, which also play an important role in aging and cancer development. Telomere length varies between species, but it is strictly controlled in all organisms.
Iftah Peretz +2 more
doaj +1 more source
Edge usage, motifs and regulatory logic for cell cycling genetic networks
, 2013 The cell cycle is a tightly controlled process, yet its underlying genetic network shows marked differences across species. Which of the associated structural features follow solely from the ability to impose the appropriate gene expression patterns?
Krzywicki, A. +2 more
core +3 more sources
The DNA damage checkpoint pathway promotes extensive resection and nucleotide synthesis to facilitate homologous recombination repair and genome stability in fission yeast. [PDF]
, 2014 DNA double-strand breaks (DSBs) can cause chromosomal rearrangements and extensive loss of heterozygosity (LOH), hallmarks of cancer cells. Yet, how such events are normally suppressed is unclear.
Blaikley, EJ +13 more
core +1 more source
An aging-independent replicative lifespan in a symmetrically dividing eukaryote
eLife, 2017 The replicative lifespan (RLS) of a cell—defined as the number of cell divisions before death—has informed our understanding of the mechanisms of cellular aging.
Eric C Spivey +4 more
doaj +1 more source
New Scaling Relation for Information Transfer in Biological Networks
, 2015 Living systems are often described utilizing informational analogies. An important open question is whether information is merely a useful conceptual metaphor, or intrinsic to the operation of biological systems.
Davies, Paul +2 more
core +2 more sources
Extensive mass spectrometry-based analysis of the fission yeast proteome: the Schizosaccharomyces pombe PeptideAtlas [PDF]
, 2013 We report a high quality and system-wide proteome catalogue covering 71% (3,542 proteins) of the predicted genes of fission yeast, Schizosaccharomyces pombe, presenting the largest protein dataset to date for this important model organism.
Aebersold +57 more
core +1 more source