Results 71 to 80 of about 34,741 (182)

Molecular Machine‐Driven Fluorogenic Probes for Motion–Signal Conversion and Hydrophilicity Retention in Live‐Cell Nanoscopy

Aggregate, Volume 7, Issue 10, October 2026.
A hydrophilicity‐retention strategy for developing fluorogenic probes by conjugating malachite green (as the molecular motion switch) with a spirocyclization‐free rhodamine (as the signal module) was developed for nanoscopic imaging of mitochondrial cristae structures and dynamics in living cells.
Yuan Luo, Lili Du, Xing Yang, Ke Liu, Chunbai Xiang, Yuanyuan Wang, Daoyong Jiang, Zihan Wu, Xiang‐Yang Lou, Xiaokang Zhang, Jiajie Diao, Xiaoshuai Huang, Ping Gong, Ben Zhong Tang, Lintao Cai, Pengfei Zhang   +15 more
wiley   +1 more source

The Sleeping Giant: Metabolism and Autophagy in the Generation and Survival of Dormant Polyploid Giant Cancer Cells

MedComm, Volume 7, Issue 10, October 2026.
Polyploid giant cancer cells (PGCCs) arise in response to stress and play a critical role in therapy resistance and tumor dormancy. These cells can evade conventional treatments and later contribute to cancer relapse by generating progeny through nonmitotic, amitotic mechanisms.
Silvia Guil‐Luna, María Teresa Sánchez‐Montero, Alejandra Díaz‐Chacón, Antonio Rodríguez‐Ariza   +3 more
wiley   +1 more source

PomBase: The Scientific Resource for Fission Yeast [PDF]

, 2018
The fission yeast Schizosaccharomyces pombe has become well established as a model species for studying conserved cell-level biological processes, especially the mechanics and regulation of cell division. PomBase integrates the S. pombe genome sequence with traditional genetic, molecular and cell biological experimental data as well as the growing body
Lock, A, Rutherford, K, Harris, MA, Wood, V   +3 more
openaire   +3 more sources

A Microfluidic Device for Massively Parallel, Whole-lifespan Imaging of Single Fission Yeast Cells

Bio-Protocol, 2018
Whole-lifespan single-cell analysis has greatly increased our understanding of fundamental cellular processes such as cellular aging. To observe individual cells across their entire lifespan, all progeny must be removed from the growth medium, typically ...
Stephen Jones Jr, Eric Spivey, Jim Rybarski, Ilya Finkelstein   +3 more
doaj   +1 more source

Metabolization of Flavan‐3‐ol Oligomers by Eggerthella lenta, a Human Gut Bacterium

Molecular Nutrition &Food Research, Volume 70, Issue 19, 15 October 2026.
Novel human gut bacterial strains were isolated and characterized for their ability to metabolize flavan‐3‐ols. While Eggerthella lenta and Flavonifractor plautii metabolized flavan‐3‐ol monomers, only E. lenta converted B‐ and A‐type procyanidins, demonstrating that this gut bacterium can metabolize flavan‐3‐ol oligomers.
Ruben Halifa, Claire Dufour, Agnes Cornu, Philippe Ruiz, Jeanne Danon, Christian Ginies, Michel Dubourdeaux, Sophie Comtet‐Marre, Pierre Peyret, Carine Le Bourvellec, Pascale Mosoni   +10 more
wiley   +1 more source

Automated morphometry toolbox for analysis of microscopic model organisms using simple bright-field imaging

Biology Open, 2019
Model organisms with compact genomes, such as yeast and Caenorhabditis elegans, are particularly useful for understanding organism growth and life/cell cycle.
Guanghui Liu, Fenfen Dong, Chuanhai Fu, Zachary J. Smith   +3 more
doaj   +1 more source

Direct Pharmacological Activation of AMPK Extends Lifespan in Yeast, Worms and Flies

Aging Cell, Volume 25, Issue 10, October 2026.
AMP‐activated protein kinase (AMPK) is a key evolutionarily conserved sensor of energy homeostasis, which is implicated in metabolic health and disease, as well as in ageing. Here, we show that direct pharmacological activation of AMPK with the compound 991 in vivo extends lifespan in multiple model organisms: the fission yeast Schizosaccharomyces ...
Eliano dos Santos, Marie Blickling, Fiona C. Leiper, John‐Patrick Alao, Claudia Lennicke, Andrea Foley, Jon R. Wilson, Steven J. Gamblin, Bénédicte Chazaud, Giovanna Lollo, Rémi Mounier, Gaëtan Juban, Charalampos Rallis, David Carling, Filipe Cabreiro, Helena M. Cochemé   +15 more
wiley   +1 more source

Mitochondrial Fusion and Fission in Age‐Related Cardio‐Cerebral Diseases: Mechanisms and Interventions

Aging Cell, Volume 25, Issue 10, October 2026.
Mitochondrial fission‐fusion imbalance contributes to age‐related cardio‐cerebral diseases like Alzheimer's disease, Parkinson's disease, Cerebral Infarction, Arteriosclerosis, Myocardial Infarction, Cardiac valve disease, Hypertension, and Cardiomyopathy. This review summarizes its regulatory mechanisms and interventions.
Yuyao Yin, Zijian Li
wiley   +1 more source

Long‐read sequencing‐based atlas of tissue‐specific expression of DNM1L transcript variants

The FEBS Journal, Volume 293, Issue 20, Page 6208-6229, October 2026.
Targeted long‐read sequencing resolves full‐length DNM1L (Drp1) isoforms and reveals conserved, tissue‐specific expression patterns across human and mouse tissues. Functional assays show that Drp1 isoforms differ in their ability to drive mitochondrial fission, independent of abundance, with specific exons modulating activity.
Feng Yan, Jafar S. Jabbari, Naomi X. L. Ling, Anne M. Kong, Jia Q. Truong, Marnie L. Maddock, Ayeshah A. Rosdah, Christopher G. Langendorf, Lifang Zhang, Jarmon G. Lees, Sebastian Bass‐Stringer, Danise Ann Onda, Alice Pébay, Mirella Dottori, Kim Loh, Jessica K. Holien, Sean Lal, Nadia M. Davidson, Jonathan S. Oakhill, Shiang Y. Lim   +19 more
wiley   +1 more source

MCM-GINS and MCM-MCM interactions in vivo visualised by bimolecular fluorescence complementation in fission yeast

BMC Cell Biology, 2009
Background Each of the three individual components of the CMG complex (Cdc45, MCM and GINS) is essential for chromosomal DNA replication in eukaryotic cells, both for the initiation of replication at origins and also for normal replication fork ...
MacNeill Stuart A, Akman Gökhan
doaj   +1 more source