Results 71 to 80 of about 76,221 (224)
The extent of error-prone replication-restart by homologous recombination is controlled by Exo1 and checkpoint proteins [PDF]
, 2014 Genetic instability, a hallmark of cancer, can occur when the replication machinery encounters a barrier. The intra-S phase checkpoint maintains stalled replication forks in a replication-competent configuration by phosphorylating replisome components ...
Ahn +80 more
core +2 more sources
Proteostasis of organelles in aging and disease
The FEBS Journal, EarlyView.Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi +5 more
wiley +1 more source
Adding phosphorylation events to the core oscillator driving the cell cycle of fission yeast.
PLoS ONE, 2018 Much is known about the regulatory elements controlling the cell cycle in fission yeast (Schizosaccharomyces pombe). This regulation is mainly done by the (cyclin-dependent kinase/cyclin) complex (Cdc2/Cdc13) that activates specific target genes and ...
Dania Humaidan +2 more
doaj +1 more source
Disease Models & Mechanisms, 2019 Mitochondria continually move, fuse and divide, and these dynamics are essential for the proper function of the organelles. Indeed, the dynamic balance of fusion and fission of mitochondria determines their morphology and allows their immediate ...
Thomas Delerue +8 more
doaj +1 more source
Exploring Genetic Interactions with Telomere Protection Gene pot1 in Fission Yeast
Biomolecules, 2023 The regulation of telomere length has a significant impact on cancer risk and aging in humans. Circular chromosomes are found in humans and are often unstable during mitosis, resulting in genome instability.
Masaru Ueno
doaj +1 more source
T-loop phosphorylation of Arabidopsis CDKA;1 is required for its function and can be partially substituted by an aspartate residue [PDF]
, 2007 As in other eukaryotes, progression through the cell cycle in plants is governed by cyclin-dependent kinases. Phosphorylation of a canonical Thr residue in the T-loop of the kinases is required for high enzyme activity in animals and yeast.
Dissmeyer, N. +7 more
core +2 more sources
GCN2 in proteostasis: structural logic, signalling networks and disease
The FEBS Journal, EarlyView.Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley +1 more source
Microscopy of Fission Yeast Sexual Lifecycle [PDF]
Journal of Visualized Experiments, 2016 The fission yeast Schizosaccharomyces pombe has been an invaluable model system in studying the regulation of the mitotic cell cycle progression, the mechanics of cell division and cell polarity. Furthermore, classical experiments on its sexual reproduction have yielded results pivotal to current understanding of DNA recombination and meiosis.
Vjestica, Aleksandar +4 more
openaire +2 more sources
Quantification of Mitochondrial Dynamics in Fission Yeast
Bio-Protocol, 2019 Mitochondria are double-membraned organelles responsible for several functions in the cell including energy production, calcium signaling, and cellular metabolism.
Leeba Chacko, Vaishnavi Ananthanarayanan
doaj +1 more source
In vitro reactivation of spindle elongation in fission yeast nuc2 mutant cells. [PDF]
, 1990 To investigate the mechanisms of spindle elongation and chromosome separation in the fission yeast Schizosaccharomyces pombe, we have developed an in vitro assay using a temperature-sensitive mutant strain, nuc2.
Cande, WZ +3 more
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