Results 61 to 70 of about 83,026 (211)

A yeast-based screening assay identifies repurposed drugs that suppress mitochondrial fusion and mtDNA maintenance defects

open access: yesDisease Models & Mechanisms, 2019
Mitochondria continually move, fuse and divide, and these dynamics are essential for the proper function of the organelles. Indeed, the dynamic balance of fusion and fission of mitochondria determines their morphology and allows their immediate ...
Thomas Delerue   +8 more
doaj   +1 more source

Identification of Fis1 Interactors in Toxoplasma gondii Reveals a Novel Protein Required for Peripheral Distribution of the Mitochondrion [PDF]

open access: yes, 2020
Toxoplasma gondii’s single mitochondrion is very dynamic and undergoes morphological changes throughout the parasite’s life cycle. During parasite division, the mitochondrion elongates, enters the daughter cells just prior to cytokinesis, and undergoes ...
Arrizabalaga, Gustavo   +2 more
core   +1 more source

Quantification of Mitochondrial Dynamics in Fission Yeast

open access: yesBio-Protocol, 2019
Mitochondria are double-membraned organelles responsible for several functions in the cell including energy production, calcium signaling, and cellular metabolism.
Leeba Chacko, Vaishnavi Ananthanarayanan
doaj   +1 more source

Indistinguishable landscapes of meiotic DNA breaks in rad50+ and rad50S strains of fission yeast revealed by a novel rad50+ recombination intermediate. [PDF]

open access: yesPLoS Genetics, 2008
The fission yeast Schizosaccharomyces pombe Rec12 protein, the homolog of Spo11 in other organisms, initiates meiotic recombination by creating DNA double-strand breaks (DSBs) and becoming covalently linked to the DNA ends of the break.
Randy W Hyppa   +2 more
doaj   +1 more source

Regulation of the SUV39H Family Methyltransferases: Insights from Fission Yeast

open access: yesBiomolecules, 2023
Histones, which make up nucleosomes, undergo various post-translational modifications, such as acetylation, methylation, phosphorylation, and ubiquitylation. In particular, histone methylation serves different cellular functions depending on the location
Rinko Nakamura, Jun-ichi Nakayama
doaj   +1 more source

Role of the Schizosaccharomyces pombe F-box DNA helicase in processing recombination intermediates. [PDF]

open access: yes, 2005
In an effort to identify novel genes involved in recombination repair, we isolated fission yeast Schizosaccharomyces pombe mutants sensitive to methyl methanesulfonate (MMS) and a synthetic lethal with rad2.
Carr, Antony M   +6 more
core   +2 more sources

Conserved Phosphorylation of the Myosin1e TH1 Domain Impacts Membrane Association and Function in Yeast and Worms

open access: yesCytoskeleton, EarlyView.
ABSTRACT Cells have an intrinsic ability to rapidly respond to environmental change to regulate cell cycle progression and membrane organisation, thereby affecting cell growth and division. The actin cytoskeleton is a highly dynamic complex of proteins that can rapidly reorganise to change the growth pattern of a cell.
Holly R. Brooker   +7 more
wiley   +1 more source

The AAA-ATPase Yta4/ATAD1 interacts with the mitochondrial divisome to inhibit mitochondrial fission.

open access: yesPLoS Biology, 2023
Mitochondria are in a constant balance of fusion and fission. Excessive fission or deficient fusion leads to mitochondrial fragmentation, causing mitochondrial dysfunction and physiological disorders.
Jiajia He   +17 more
doaj   +1 more source

Multi-Layered Regulations on the Chromatin Architectures: Establishing the Tight and Specific Responses of Fission Yeast fbp1 Gene Transcription

open access: yesBiomolecules, 2022
Transcriptional regulation is pivotal for all living organisms and is required for adequate response to environmental fluctuations and intercellular signaling molecules.
Ryuta Asada, Kouji Hirota
doaj   +1 more source

Mechanical Coupling With the Nuclear Envelope Shapes the Schizosaccharomyces pombe Mitotic Spindle

open access: yesCytoskeleton, EarlyView.
ABSTRACT The fission yeast Schizosaccharomyces pombe divides via closed mitosis, meaning that spindle elongation and chromosome segregation transpire entirely within the closed nuclear envelope. Both the spindle and nuclear envelope must undergo shape changes and exert varying forces on each other during this process.
Marcus A. Begley   +8 more
wiley   +1 more source

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