Results 71 to 80 of about 83,026 (211)

Parameter identification problems in the modelling of cell motility [PDF]

, 2014
We present a novel parameter identification algorithm for the estimation of parameters in models of cell motility using imaging data of migrating cells.
A Friedman, A Mogilner, AM Stuart, AS Ackleh, AS Ackleh, B Onken, Björn Stinner, C Hogea, C Jiang, C Weston, Cathryn Weston, Chandrasekhar Venkataraman, Charles M. Elliott, CT Kelley, D Bray, D Dormann, DW Marquardt, F Haußer, FD Kelly, G Dziuk, G Dziuk, G Dziuk, G Dziuk, Graham Ladds, H Tatebe, I Hecht, IF Sbalzarini, J Alamo Del, J Barrett, J Barrett, J Nocedal, J Satulovsky, JF Monahan, K Deckelnick, K Deckelnick, L Bosgraaf, M Burger, M Herant, M Lombardi, M Mos, M Neilson, MA Dewar, MA Iglesias, MJ Pittet, MR Garvie, O Lakkis, R Lefever, T Drake, TF Chan, V Isakov, Wayne Croft   +50 more
core   +1 more source

Comparative Analysis of Septin Modifiers, Forchlorfenuron and UR214‐9, on Mitochondrial Fragmentation and Lytic Cell Death

Cytoskeleton, EarlyView.
ABSTRACT Septins are conserved GTP‐binding proteins that play key roles in cell division, mitochondrial dynamics and immune responses. Despite their importance to human health, pharmacological compounds to modify septins remain limited. Forchlorfenuron (FCF) was the first small molecule identified to modify septins, disrupting their organisation and ...
Dominik Brokatzky, Rajdeep Das, Hannah Painter, Rakesh K. Singh, Serge Mostowy   +4 more
wiley   +1 more source

A new pma1 mutation identified in a chronologically long-lived fission yeast mutant

FEBS Open Bio, 2014
We isolated a chronologically long-lived mutant of Schizosaccharomyces pombe and found a new mutation in pma1+ that encoded for an essential P-type proton ATPase.
Chikako Naito, Hirokazu Ito, Tomoko Oshiro, Hokuto Ohtsuka, Hiroshi Murakami, Hirofumi Aiba   +5 more
doaj   +1 more source

External and internal triggers of cell death in yeast [PDF]

, 2016
In recent years, yeast was confirmed as a useful eukaryotic model system to decipher the complex mechanisms and networks occurring in higher eukaryotes, particularly in mammalian cells, in physiological as well in pathological conditions.
FALCONE, Claudio, MAZZONI, Cristina
core   +2 more sources

From Yeast to Therapeutics: Modeling Neurodegenerative Diseases in Saccharomyces cerevisiae

Yeast, EarlyView.
Yeast plasmids expressing human Aβ‐42, α‐syn, htt, and TDP‐43. Their fate includes an equilibrium between the endocytic pathway and aggregates that potentially disrupt endocytosis, vesicular transport, vacuolar autophagy, and mitochondrial activity. ABSTRACT Here, we review the use of Saccharomyces cerevisiae as a powerful model organism for studying ...
Jose Ribamar Ferreira‐Junior, Vittoria de Lima Camandona, Mario H. Barros   +2 more
wiley   +1 more source

Bayesian meta-analysis for identifying periodically expressed genes in fission yeast cell cycle

, 2010
The effort to identify genes with periodic expression during the cell cycle from genome-wide microarray time series data has been ongoing for a decade. However, the lack of rigorous modeling of periodic expression as well as the lack of a comprehensive ...
Fan, Xiaodan, Liu, Jun S., Pyne, Saumyadipta   +2 more
core   +1 more source

The physiological and pathological effects of sphingolipid metabolism and signaling in the central nervous system

Brain Pathology, EarlyView.
Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li, Haoying He, Ejuan Zhang, Fengjiao Hu, Zhuo Wang, Jian Xu, Mengliu Zeng, Biwen Peng   +7 more
wiley   +1 more source

Automated morphometry toolbox for analysis of microscopic model organisms using simple bright-field imaging

Biology Open, 2019
Model organisms with compact genomes, such as yeast and Caenorhabditis elegans, are particularly useful for understanding organism growth and life/cell cycle.
Guanghui Liu, Fenfen Dong, Chuanhai Fu, Zachary J. Smith   +3 more
doaj   +1 more source

The Rad9-Hus1-Rad1 Checkpoint Clamp Regulates Interaction of TopBP1 with ATR [PDF]

, 2007
TopBP1 serves as an activator of the ATR-ATRIP complex in response to the presence of incompletely replicated or damaged DNA. This process involves binding of ATR to the ATR-activating domain of TopBP1, which is located between BRCT domains VI and VII ...
Dunphy, William G., Kumagai, Akiko, Lee, Joon   +2 more
core   +2 more sources

Fraternal cooperation of hierarchical cancer parallels metazoan multicellularity and eusociality

Biological Reviews, EarlyView.
ABSTRACT Metazoan multicellularity and eusociality — both outcomes of the fraternal major transitions — have numerous features in common such as uneven distribution of group‐establishing potential. In addition to this framework, I argue herein that the group‐forming principles of metazoan multicellularity and eusociality are analogous to hierarchical ...
Jibeom Choi
wiley   +1 more source