Results 151 to 160 of about 13,276,511 (306)

Some fixed point theorems for discontinuous mappings [PDF]

This paper provides a fixed point theorem à la Schauder, where the mappings considered are possibly discontinuous. Our main result generalizes and unifies several well-known results.Schauder fixed point theorem, Brouwer fixed point theorem, discontinuity.
Philippe Bich
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Optimizing fixed-time laparoscopic artificial insemination in the jaguar. [PDF]

Reprod Fertil
Vansandt LM, Adania CH, Yanai PR, da Silva Paulino J, da Paz RCR, Bateman HL, Donelan EM, Swanson WF.   +7 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Fixed-time Observer-based Saturated Nonsingular Terminal Sliding Mode Controller Design for an Over-actuated ROV with Time-varying Saturation Limits

Fixed-time Observer-based Saturated Nonsingular Terminal Sliding Mode Controller Design for an Over-actuated ROV with Time-varying Saturation ...
Navid Mohajer (13086873), Alireza Hosseinnajad (16638228)   +1 more
core  

Applications General Terms Languages, Simulation Keywords Program Specialization, Fixed-point Simulation, SystemC,

, 2008
Generic simulation components, such as fixed-precision arithmetic routines, make it easier to quickly assemble system simulations, but generic components tend to simulate more slowly than their manually-written specialized counterparts.
Systemc Fixed-point Simulation
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Follicular dynamics and hormonal profile in Prepubertal nelore and Murrah heifers subjected to fixed-time artificial insemination (FTAI). [PDF]

Anim Reprod
Bêta IO, Gonçalves LPN, Pacheco A, de Almeida YEF, Prado AJ, Baruselli PS, Neves KAL, Minervino AHH.   +7 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Adaptive Fuzzy Fixed-Time Trajectory Tracking Control for a Piezoelectric-Driven Microinjector. [PDF]

Micromachines (Basel)
Zhang R, Wu Z, Zhang W, Xu Q.
europepmc   +1 more source