Results 11 to 20 of about 36,346 (215)
Therapeutic Drug Monitoring, 1993 In this study, we used solid-phase extraction with Sep-Pak and a liquid-liquid extraction with methylene chloride as two primary methods of extracting FK506 from plasma. The extracts were either analyzed directly by enzyme-linked immunosorbent assay (ELISA) or subjected to high-performance liquid chromatography (HPLC) separation and different fractions
Warty, VS +5 more
openaire +2 more sources
Pharmacokinetics of FK506 in liver transplant recipients after continuous intravenous infusion [PDF]
, 1993 The first-dose pharmacokinetics of FK506 was studied in nine orthotopic liver transplant patients receiving continuous intravenous infusion of 0.15 mg/kg/day.
Abu-Elmagd +16 more
core +1 more source
CAQ Corner: Basic concepts of transplant immunology
, 2022 Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley +1 more source
Combined immunosuppressive therapy with low dose FK506 and antimetabolites in rat allogeneic heart transplantation [PDF]
, 1994 Following rat heterotopic heart allotransplantation, low to lethal doses of the antimetabolites mizoribine (MIZ), RS-61443 (RS), and AZA were given alone or in combination with subtherapeutic doses of FK506 (0.04 mg/kg/day) for 14 days after ...
Fujisaki, S +6 more
core +1 more source
Tacrolimus (FK506)-Associated Renal Pathology [PDF]
Advances in Anatomic Pathology, 1997 A variety of renal lesions have been described in patients undergoing episodes of tacrolimus nephrotoxicity. Although helpful to the pathologist seeking morphologic clues to substantiate drug toxicity, none of these lesions is specific to the extent that it has not been reported in other conditions.
Randhawa, Parmjeet S +2 more
openaire +2 more sources
Induction of liver transplant immune tolerance in an outbred rat strain model using tacrolimus
Laboratory Animal Research, 2023 Background Orthotopic liver transplantation is the only option for patients with end-stage liver disease and hepatocellular carcinoma. Post-transplant immunosuppressive therapy is important to prevent graft failure.
Min-Jung Park +9 more
doaj +1 more source
Bioactive Materials, 2022 Dry eye is a common ocular disease that results in discomfort and impaired vision, impacting an individual's quality of life. A great number of drugs administered in eye drops to treat dry eye are poorly soluble in water and are rapidly eliminated from ...
Yi Han +14 more
doaj +1 more source
Fk506 “rescue” for resistant rejection of renal allografts under primary cyclosporine immunosuppression [PDF]
, 1994 Seventy-seven patients with ongoing acute rejection on initial CsA therapy were converted to FK506 to attempt graft salvage. Fifty-nine patients had undergone primary transplantation and 18 had been retransplanted; there were 52 cadaveric and 25 living ...
Carrieri, G +12 more
core +1 more source
HEPATOTROPHIC EFFECTS OF FK506 IN DOGS [PDF]
Transplantation, 1991 Portacaval shunt (Eck fistula) in dogs causes hepatocyte atrophy and organelle disruption, as well as tripling of hepatocyte mitoses. After submitting dogs to this procedure, FK506 was infused into the tied-off left portal vein. The size, anatomic quality, and replication of hepatocytes were enhanced in the portion of liver infused with FK506, with a ...
T. E. Starzl +5 more
openaire +3 more sources
Drug Delivery, 2017 Immune rejection after transplantation is common, which leads to prompt failure of the graft. Therefore, to prolong the survival time of the graft, immunosuppressive therapy is the norm.
Shiva Pathak +12 more
doaj +1 more source