Results 31 to 40 of about 23,499 (227)

FK506 Induces the TGF-β1/Smad 3 Pathway Independently of Calcineurin Inhibition to Prevent Intervertebral Disk Degeneration

Frontiers in Cell and Developmental Biology, 2020
BackgroundIntervertebral disk (IVD) degeneration is the most common cause of lower back pain. Inhibiting inflammation is a key strategy for delaying IVD degeneration.
Jun Ge, Yingjie Wang, Qi Yan, Cenhao Wu, Hao Yu, Huilin Yang, Jun Zou   +6 more
doaj   +1 more source

Effect of Kaempferol on Tacrolimus-Induced Nephrotoxicity and Calcineurin B1 Expression Level in Animal Model

Journal of Experimental Pharmacology, 2020
Ahmed Shaker Ali,1,2 Abdullah Saddah Almalki,1,3 Basma Tarek Alharthy1 1Department of Pharmacology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia; 2Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt;
Ali AS, Almalki AS, Alharthy BT
doaj  

FK506 Attenuated Pilocarpine-Induced Epilepsy by Reducing Inflammation in Rats

Frontiers in Neurology, 2019
Background: The status epilepticus (SE) is accompanied by a local inflammatory response and many oxygen free radicals. FK506 is an effective immunosuppressive agent with neuroprotective and neurotrophic effects, however, whether it can inhibit the ...
Aihua Wang, Aihua Wang, Zhihua Si, Zhihua Si, Xiaolin Li, Xiaolin Li, Lu Lu, Lu Lu, Yongli Pan, Yongli Pan, Jinzhi Liu, Jinzhi Liu   +11 more
doaj   +1 more source

Role of FK506-sensitive signals in asthmatic lung inflammation

Frontiers in Immunology, 2022
Asthma is airway inflammatory diseases caused by the activation of group 2 innate lymphoid cells (ILC2s) and type 2 helper T (TH2) cells. Cysteine proteases allergen cause tissue damage to airway epithelial cells and activate ILC2-mediated type 2 airway ...
Chihiro Tomiaki, Kosuke Miyauchi, Sewon Ki, Yoshie Suzuki, Narumi Suzuki, Hiroshi Morimoto, Yohei Mukoyama, Masato Kubo, Masato Kubo   +8 more
doaj   +1 more source

FK506 contributes to peripheral nerve regeneration by inhibiting neuroinflammatory responses and promoting neuron survival

Neural Regeneration Research
FK506 (Tacrolimus) is a systemic immunosuppressant approved by the U.S. Food and Drug Administration. FK506 has been shown to promote peripheral nerve regeneration, however, its precise mechanism of action and its pathways remain unclear.
Yuhui Kou, Zongxue Jin, Yusong Yuan, Bo Ma, Wenyong Xie, Na Han   +5 more
doaj   +1 more source

Tacrolimus (FK506) prevents early stages of ethanol induced hepatic fibrosis by targeting LARP6 dependent mechanism of collagen synthesis.

PLoS ONE, 2013
Tacrolimus (FK506) is a widely used immunosuppressive drug. Its effects on hepatic fibrosis have been controversial and attributed to immunosuppression.
Zarko Manojlovic, John Blackmon, Branko Stefanovic   +2 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Pharmacological Inhibition of FKBP51 Mitigates Early Life Adversity‐Induced Social Deficits in Male Mice

Advanced Science, EarlyView.
Early life adversity triggers persistent social subordination and brain‐wide molecular dysregulation. Pharmacological inhibition of the stress‐mediator FKBP51 during the adversity period prevents these long‐term deficits and restores normative social hierarchy.
Joeri Bordes, Xiuqi Ji, Serena Gasperoni, Choham Sudre‐Chinsky, Amirali Kalbasi, Daniela Harbich, Cornelia Flachskamm, Paula Fontanet, Sowmya Narayan, Manfred Uhr, Christian Namendorf, Camilla Bellone, Alon Chen, Felix Hausch, Juan Pablo Lopez, Mathias V. Schmidt   +15 more
wiley   +1 more source

InterAKTions with FKBPs - mutational and pharmacological exploration

, 2013
The FK506-binding protein 51 (FKBP51) is an Hsp90-associated co-chaperone which regulates steroid receptors and kinases. In pancreatic cancer cell lines, FKBP51 was shown to recruit the phosphatase PHLPP to facilitate dephosphorylation of the kinase Akt,
Andreas März, Ricardo M Biondi, Sonja Neimanis, Anne-Katrin Fabian (383323), März, Andreas, Biondi, R., Biondi, Ricardo M., Ricardo M. Biondi (22855), Christian Kozany (26598), Kozany, Christian, Anne-Katrin Fabian, Hausch, F., Neimanis, S., Andreas März (383324), Hausch, Felix, Felix Hausch, Sonja Neimanis (383325), Christian Kozany, März, A., Kozany, C., Neimanis, Sonja, Felix Hausch (383326), Fabian, A., Fabian, Anne-Katrin   +23 more
core   +2 more sources

FK506 biosynthesis is regulated by two positive regulatory elements in Streptomyces tsukubaensis

BMC Microbiology, 2012
Background FK506 (Tacrolimus) is an important immunosuppressant, produced by industrial biosynthetic processes using various Streptomyces species.
Goranovič Dušan, Blažič Marko, Magdevska Vasilka, Horvat Jaka, Kuščer Enej, Polak Tomaž, Santos-Aberturas Javier, Martínez-Castro Miriam, Barreiro Carlos, Mrak Peter, Kopitar Gregor, Kosec Gregor, Fujs Štefan, Martín Juan F, Petković Hrvoje   +14 more
doaj   +1 more source