Results 21 to 30 of about 23,499 (227)
Bioactive Materials, 2022 Dry eye is a common ocular disease that results in discomfort and impaired vision, impacting an individual's quality of life. A great number of drugs administered in eye drops to treat dry eye are poorly soluble in water and are rapidly eliminated from ...
Yi Han +14 more
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Drug Delivery, 2017 Immune rejection after transplantation is common, which leads to prompt failure of the graft. Therefore, to prolong the survival time of the graft, immunosuppressive therapy is the norm.
Shiva Pathak +12 more
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Induction of liver transplant immune tolerance in an outbred rat strain model using tacrolimus
Laboratory Animal Research, 2023 Background Orthotopic liver transplantation is the only option for patients with end-stage liver disease and hepatocellular carcinoma. Post-transplant immunosuppressive therapy is important to prevent graft failure.
Min-Jung Park +9 more
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Journal of Experimental Pharmacology, 2023 Ali AS, Almalki AS, Alharthy BT. J Exp Pharmacol. 2020;12:397–407. The authors have advised that the Acknowledgments statement on page 405 is incorrect.
Ali AS, Almalki AS, Alharthy BT
doaj
Frontiers in Bioengineering and Biotechnology, 2021 Eye drops account for more than 90% of commercialized ophthalmic drugs. However, eye drops have certain shortcomings, such as short precorneal retention time and weak corneal penetration.
Xueqi Lin +13 more
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Neural Regeneration Research, 2018 After decades of research, peripheral nerve injury and repair still frequently results in paralysis, chronic pain and neuropathies leading to severe disability in patients.
Brett Davis +6 more
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Characterization of the FKBP12-Encoding Genes in Aspergillus fumigatus. [PDF]
PLoS ONE, 2015 Invasive aspergillosis, largely caused by Aspergillus fumigatus, is responsible for a growing number of deaths among immunosuppressed patients. Immunosuppressants such as FK506 (tacrolimus) that target calcineurin have shown promise for antifungal drug ...
Katie Falloon +5 more
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FK506 in solid organ transplantation [PDF]
, 1995 FK506 (Prograf) is a new immunosuppressive agent, recently approved for use in solid organ transplants. The first use of FK506 was for the indication of refractory liver allograft rejection.
Starzl, TE, Fung, JJ
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Renal Tubular Acidosis Secondary to FK506 in Living Donor Liver Transplantation: A Case Report
Asian Journal of Surgery, 2003 FK506 is an immunosuppressant that is thought to be less nephrotoxic than cyclosporine A. However, complications due to renal tubular acidosis (RTA) have recently been reported.
Keiko Ogita +3 more
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Interactions of FK506 and Rapamycin With FK506 Binding Protein 12 in Opportunistic Human Fungal Pathogens [PDF]
Frontiers in Molecular Biosciences, 2020 Over the past few decades advances in modern medicine have resulted in a global increase in the prevalence of fungal infections. Particularly people undergoing organ transplants or cancer treatments with a compromised immune system are at an elevated risk for lethal fungal infections such as invasive candidiasis, aspergillosis, cryptococcosis, etc. The
Sandeep Vellanki +2 more
openaire +3 more sources