Results 21 to 30 of about 24,113 (230)

Effectiveness of an ocular adhesive polyhedral oligomeric silsesquioxane hybrid thermo-responsive FK506 hydrogel in a murine model of dry eye

Bioactive Materials, 2022
Dry eye is a common ocular disease that results in discomfort and impaired vision, impacting an individual's quality of life. A great number of drugs administered in eye drops to treat dry eye are poorly soluble in water and are rapidly eliminated from ...
Yi Han, Lu Jiang, Huihui Shi, Chenfang Xu, Minting Liu, Qingjian Li, Lan Zheng, Hong Chi, Mingyue Wang, Zuguo Liu, Mingliang You, Xian Jun Loh, Yun-Long Wu, Zibiao Li, Cheng Li   +14 more
doaj   +1 more source

Effect of Kaempferol on Tacrolimus-Induced Nephrotoxicity and Calcineurin B1 Expression Level in Animal Model [Corrigendum]

Journal of Experimental Pharmacology, 2023
Ali AS, Almalki AS, Alharthy BT. J Exp Pharmacol. 2020;12:397–407. The authors have advised that the Acknowledgments statement on page 405 is incorrect.
Ali AS, Almalki AS, Alharthy BT
doaj  

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

InterAKTions with FKBPs - mutational and pharmacological exploration [PDF]

, 2013
The FK506-binding protein 51 (FKBP51) is an Hsp90-associated co-chaperone which regulates steroid receptors and kinases. In pancreatic cancer cell lines, FKBP51 was shown to recruit the phosphatase PHLPP to facilitate dephosphorylation of the kinase Akt,
Andreas März, Ricardo M Biondi, Sonja Neimanis, Anne-Katrin Fabian (383323), März, Andreas, Biondi, R., Biondi, Ricardo M., Ricardo M. Biondi (22855), Christian Kozany (26598), Kozany, Christian, Anne-Katrin Fabian, Hausch, F., Neimanis, S., Andreas März (383324), Hausch, Felix, Felix Hausch, Sonja Neimanis (383325), Christian Kozany, März, A., Kozany, C., Neimanis, Sonja, Felix Hausch (383326), Fabian, A., Fabian, Anne-Katrin   +23 more
core   +2 more sources

FK506はオートファジーを活性化することで異常型プリオンタンパクの分解を促進し、プリオン感染マウスの生存期間を延長する [PDF]

, 2013
Prion diseases are fatal neurodegenerative disorders and no effective treatment has been established to date. In this study, we evaluated the effect of FK506 (tacrolimus), a macrolide that is known to be a mild immunosuppressant, on prion infection ...
Shigematsu, Kazuto, Kamatari, Yuji O., Nakagaki, Takehiro, Sano, Kazunori, Takenouchi, Takato, Kuwata, Kazuo, Iwamaru, Yoshifumi, Satoh, Katsuya, Fuse, Takayuki, Nishida, Noriyuki, Ishibashi, Daisuke, Atarashi, Ryuichiro, 中垣, 岳大, Kitani, Hiroshi   +13 more
core   +1 more source

Inhibition of Neovascularization and Inflammation in a Mouse Model of Corneal Alkali Burns Using Cationic Liposomal Tacrolimus

Frontiers in Bioengineering and Biotechnology, 2021
Eye drops account for more than 90% of commercialized ophthalmic drugs. However, eye drops have certain shortcomings, such as short precorneal retention time and weak corneal penetration.
Xueqi Lin, Xueqi Lin, Xuewen Yu, Xuewen Yu, Xiang Chen, Xiang Chen, Siting Sheng, Siting Sheng, Jingwen Wang, Jingwen Wang, Ben Wang, Ben Wang, Wen Xu, Wen Xu   +13 more
doaj   +1 more source

Controlled release of FK506 from micropatterned PLGA films: potential for application in peripheral nerve repair

Neural Regeneration Research, 2018
After decades of research, peripheral nerve injury and repair still frequently results in paralysis, chronic pain and neuropathies leading to severe disability in patients.
Brett Davis, Susan Wojtalewicz, Pratima Labroo, Jill Shea, Himanshu Sant, Bruce Gale, Jayant Agarwal   +6 more
doaj   +1 more source

Characterization of the FKBP12-Encoding Genes in Aspergillus fumigatus. [PDF]

PLoS ONE, 2015
Invasive aspergillosis, largely caused by Aspergillus fumigatus, is responsible for a growing number of deaths among immunosuppressed patients. Immunosuppressants such as FK506 (tacrolimus) that target calcineurin have shown promise for antifungal drug ...
Katie Falloon, Praveen R Juvvadi, Amber D Richards, José M Vargas-Muñiz, Hilary Renshaw, William J Steinbach   +5 more
doaj   +1 more source

Renal Tubular Acidosis Secondary to FK506 in Living Donor Liver Transplantation: A Case Report

Asian Journal of Surgery, 2003
FK506 is an immunosuppressant that is thought to be less nephrotoxic than cyclosporine A. However, complications due to renal tubular acidosis (RTA) have recently been reported.
Keiko Ogita, Narito Takada, Tomoaki Taguchi, Sachiyo Suita   +3 more
doaj   +1 more source

FK506 in solid organ transplantation [PDF]

, 1995
FK506 (Prograf) is a new immunosuppressive agent, recently approved for use in solid organ transplants. The first use of FK506 was for the indication of refractory liver allograft rejection.
Starzl, TE, Fung, JJ
core   +1 more source