Results 11 to 20 of about 23,499 (227)
Drug Delivery, 2021 FK506, a first-line immunosuppressant, is routinely administered orally and intravenously to inhibit activation and proliferation of T cells after heart transplantation (HT).
Cheng Deng +14 more
doaj +2 more sources
Therapeutic Drug Monitoring, 1993 In this study, we used solid-phase extraction with Sep-Pak and a liquid-liquid extraction with methylene chloride as two primary methods of extracting FK506 from plasma. The extracts were either analyzed directly by enzyme-linked immunosorbent assay (ELISA) or subjected to high-performance liquid chromatography (HPLC) separation and different fractions
Warty, VS +5 more
openaire +4 more sources
Parasitology, 2017 SUMMARYFK506 and rapamycin (Rap) are immunosuppressive drugs that act principally on T-lymphocytes. The receptors for both drugs are FK506-binding proteins (FKBPs), but the molecular mechanisms of immunosuppression differ. An FK506–FKBP complex inhibits the protein phosphatase calcineurin, blocking a key step in T-cell activation, while the Rap –FKBP ...
PAUL MONAGHAN +3 more
openaire +3 more sources
Therapeutic Effects of FK506 on IgA Nephropathy Rat
Kidney & Blood Pressure Research, 2017 Background/Aims: FK506 is an immunosuppressive drug and a calcineurin inhibitor that has been widely used in kidney disease in recent years. FK506 shows a wide range of biological and pharmaceutical effects; however, the mechanism of its anti ...
Linting Wei +12 more
doaj +2 more sources
, 2022 (A) Representative images of 80 hpf superior AV valves imaged in the beating heart of embryos treated with DMSO or FK506 from 60 to 80 hpf. Cyan arrowheads point to the gap between the AVC wall and the inner layer of the valve leaflet. Scale bars: 10 μm.
Nathalie Faggianelli-Conrozier (11949875) +13 more
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Targeted Therapy for Acute Autoimmune Myocarditis with Nano-Sized Liposomal FK506 in Rats. [PDF]
PLoS ONE, 2016 Immunosuppressive agents are used for the treatment of immune-mediated myocarditis; however, the need to develop a more effective therapeutic approach remains. Nano-sized liposomes may accumulate in and selectively deliver drugs to an inflammatory lesion
Keiji Okuda +19 more
doaj +1 more source
FK506-treated embryos have increased twist1b expression at 65 hpf.
, 2022 (A, C) Wild-type embryos were treated with DMSO or FK506 from 60 hpf, fixed at 65 hpf, and twist1b RNAscope was performed. (A) Representative images of developing superior AV valves at 65 hpf that have been stained using the twist1b probe in DMSO-treated
Nathalie Faggianelli-Conrozier (11949875) +13 more
core +1 more source
Microbial Cell Factories, 2021 Background FK506, a macrolide mainly with immunosuppressive activity, can be produced by various Streptomyces strains. However, one of the major challenges in the fermentation of FK506 is its insufficient production, resulting in high fermentation costs ...
Qing-Bin Wu +3 more
doaj +1 more source
CAQ Corner: Basic concepts of transplant immunology
, 2022 Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley +1 more source
Loss of secretory pathway FK506-binding proteins results in cold-sensitive lethality in caenorhabditis elegans [PDF]
, 2007 The FK506-binding proteins (FKBs) represent ubiquitous enzymes that catalyse the rate-limiting peptidyl prolyl cis-trans isomerization step in protein folding. The nematode <i>Caenorhabditis elegans</i> has eight FKBs, three of which (FKB-3, -
Page, Antony P. +7 more
core +1 more source