Results 41 to 50 of about 24,113 (230)

The emerging role of FKBP51 in melanoma: characterization of a promising molecular target for innovative therapies [PDF]

, 2010
Melanoma is a malignant skin cancer with high metastatic potential. The number of melanoma cases worldwide is increasing faster than any other cancer.
Romano, Simona
core   +1 more source

Tacrolimus (FK506) prevents early stages of ethanol induced hepatic fibrosis by targeting LARP6 dependent mechanism of collagen synthesis.

PLoS ONE, 2013
Tacrolimus (FK506) is a widely used immunosuppressive drug. Its effects on hepatic fibrosis have been controversial and attributed to immunosuppression.
Zarko Manojlovic, John Blackmon, Branko Stefanovic   +2 more
doaj   +1 more source

Role of FK506-sensitive signals in asthmatic lung inflammation

Frontiers in Immunology, 2022
Asthma is airway inflammatory diseases caused by the activation of group 2 innate lymphoid cells (ILC2s) and type 2 helper T (TH2) cells. Cysteine proteases allergen cause tissue damage to airway epithelial cells and activate ILC2-mediated type 2 airway ...
Chihiro Tomiaki, Kosuke Miyauchi, Sewon Ki, Yoshie Suzuki, Narumi Suzuki, Hiroshi Morimoto, Yohei Mukoyama, Masato Kubo, Masato Kubo   +8 more
doaj   +1 more source

SAV1 in Cooperation With FKBP52 Participates in Implantation

Advanced Science, EarlyView.
The MST‐SAV1 complex modulates FKBP52 phosphorylation to fine‐tune PR activity, ensuring timely uterine transition to receptivity under estrogen signaling for implantation. Stromal SAV1 scaffolds MST1/2‐mediated FKBP52 phosphorylation via noncanonical Hippo to promote PR activity.
Yuhan Shao, Yafang Lu, Zhaoyu Jia, Junxiang Ren, Ziyi Ge, Xinyu Liu, Hui Zhao, Zi‐Jiang Chen, Junhao Yan, Wei Wang, Jia Yuan   +10 more
wiley   +1 more source

FK506 biosynthesis is regulated by two positive regulatory elements in Streptomyces tsukubaensis

BMC Microbiology, 2012
Background FK506 (Tacrolimus) is an important immunosuppressant, produced by industrial biosynthetic processes using various Streptomyces species.
Goranovič Dušan, Blažič Marko, Magdevska Vasilka, Horvat Jaka, Kuščer Enej, Polak Tomaž, Santos-Aberturas Javier, Martínez-Castro Miriam, Barreiro Carlos, Mrak Peter, Kopitar Gregor, Kosec Gregor, Fujs Štefan, Martín Juan F, Petković Hrvoje   +14 more
doaj   +1 more source

The Mechanism of Action of Cyclosporin A and FK506

Clinical Immunology and Immunopathology, 1996
The immunosuppressants cyclosporin A (CsA), FK506, and rapamycin suppress the immune response by inhibiting evolutionary conserved signal transduction pathways. CsA, FK506, and rapamycin bind to their intracellular receptors, immunophilins, creating composite surfaces that block the activity of specific targets.
S, Ho, N, Clipstone, L, Timmermann, J, Northrop, I, Graef, D, Fiorentino, J, Nourse, G R, Crabtree   +7 more
openaire   +2 more sources

A Versatile DNA‐Encoded Library Platform for the Discovery of Highly Cooperative Chemical Inducers of Proximity

Advanced Science, EarlyView.
We present a versatile DNA‐encoded library (DEL) platform designed for rapid library synthesis and subsequent screening for chemical inducers of proximity (CIPs) across various presenter proteins of choice. Applying this approach, we discovered a novel molecular glue‐like compound mediating CRBN‐BRD9 ternary complex formation with remarkable ...
Bingqi Tong, Sunny A. Tang, Yifan Deng, Zhihan Nan, Alison X. Gao, Gregory A. Michaud, Simone Bonazzi, Frédéric Berst, Frédéric J. Zécri, Shuang Liu, William J. Gibson, Stuart L. Schreiber   +11 more
wiley   +1 more source

FK506-binding protein like (FKBPL) has an important role in heart failure with preserved ejection fraction pathogenesis with potential diagnostic utility

, 2023
Heart failure (HF) is the leading cause of hospitalisations worldwide, with only 35% of patients surviving the first 5 years after diagnosis. The pathogenesis of HF with preserved ejection fraction (HFpEF) is still unclear, impeding the implementation of
Lana McClements (282400), Djurdja Jerotić (14772450), Milorad Tešić (14772451), Michael Chhor (10677348), Kenneth McDonald (6640754), Mark Ledwidge (299429), Chris J Watson (10123714), Tracy Robson (7896278), Milan Pavlović (14772457), Kristine C McGrath (14772465), Hao Chen (5190), Benjamin Rayner (10687624), Valentina N Nikolić (14772454), Rada M Vučić (14772459)   +13 more
core   +1 more source

Tacrolimus@ZIF-8/HTCC eye drop mediated transcorneal delivery of tacrolimus for preventing high-risk keratoplasty rejection

Materials & Design
Immune-mediated graft rejection (IMGR) remains a leading cause of corneal transplant (CT) failure in high-risk cases. While transcorneal delivery of tacrolimus (FK506) is a promising strategy, the cornea’s barrier properties severely limit FK506′s ...
Dadong Jia, Mingshuang Li, Mian Qin, Kaili Wu, Changying Yang, Jiabing Ran, Liang Liang   +6 more
doaj   +1 more source

A ROS‐Responsive and Mucoadhesive Thermosensitive Hydrogel Encapsulated with Mizoribine for Synergistic Dry Eye Therapy

Advanced Science, EarlyView.
The ROS‐responsive in situ thermosensitive MZR@SPPP hydrogel system enables dual‐stage drug loading and sustained ocular delivery. Upon administration, it gelates at ocular surface temperature, enhancing ocular adhesion. By scavenging free radicals, restoring NRF2‐mediated antioxidant defense and mitochondrial homeostasis, and suppressing inflammatory ...
Danyi Qin, Jiani Li, Panqin Ma, Shinan Wu, Wenying Guan, Yimin Huang, Ke Feng, Mingyan Wei, Zixuan Yang, Shujia Guo, Caihong Huang, Yun‐Long Wu, Yi Han, Zuguo Liu   +13 more
wiley   +1 more source