Results 41 to 50 of about 23,499 (227)

Treatment With Calcineurin Inhibitor FK506 Attenuates Noise-Induced Hearing Loss

Frontiers in Cell and Developmental Biology, 2021
Attenuation of noise-induced hair cell loss and noise-induced hearing loss (NIHL) by treatment with FK506 (tacrolimus), a calcineurin (CaN/PP2B) inhibitor used clinically as an immunosuppressant, has been previously reported, but the downstream ...
Zu-Hong He, Song Pan, Hong-Wei Zheng, Qiao-Jun Fang, Kayla Hill, Su-Hua Sha   +5 more
doaj   +1 more source

Calcineurin‐Dependent Stress Adaptation Enables Caspofungin Heteroresistance Leading to Stable Resistance in Candida Glabrata

Advanced Science, EarlyView.
Caspofungin heteroresistance is prevalent in clinical Candida glabrata isolates and depends on calcineurin‐mediated stress adaptation. This transient phenotype serves as a reservoir for resistance evolution, enabling the emergence of stable resistant descendants under prolonged drug pressure.
Yanyu Su, Yi Li, Meng Xiao, Dan Guo, David S. Perlin, Erika Shor, Yingchun Xu, Yingxing Li   +7 more
wiley   +1 more source

The Mechanism of Action of Cyclosporin A and FK506

Clinical Immunology and Immunopathology, 1996
The immunosuppressants cyclosporin A (CsA), FK506, and rapamycin suppress the immune response by inhibiting evolutionary conserved signal transduction pathways. CsA, FK506, and rapamycin bind to their intracellular receptors, immunophilins, creating composite surfaces that block the activity of specific targets.
S, Ho, N, Clipstone, L, Timmermann, J, Northrop, I, Graef, D, Fiorentino, J, Nourse, G R, Crabtree   +7 more
openaire   +2 more sources

FK506はオートファジーを活性化することで異常型プリオンタンパクの分解を促進し、プリオン感染マウスの生存期間を延長する

, 2013
Prion diseases are fatal neurodegenerative disorders and no effective treatment has been established to date. In this study, we evaluated the effect of FK506 (tacrolimus), a macrolide that is known to be a mild immunosuppressant, on prion infection ...
Shigematsu, Kazuto, Kamatari, Yuji O., Nakagaki, Takehiro, Sano, Kazunori, Takenouchi, Takato, Kuwata, Kazuo, Iwamaru, Yoshifumi, Satoh, Katsuya, Fuse, Takayuki, Nishida, Noriyuki, Ishibashi, Daisuke, Atarashi, Ryuichiro, 中垣, 岳大, Kitani, Hiroshi   +13 more
core   +2 more sources

Tacrolimus@ZIF-8/HTCC eye drop mediated transcorneal delivery of tacrolimus for preventing high-risk keratoplasty rejection

Materials & Design
Immune-mediated graft rejection (IMGR) remains a leading cause of corneal transplant (CT) failure in high-risk cases. While transcorneal delivery of tacrolimus (FK506) is a promising strategy, the cornea’s barrier properties severely limit FK506′s ...
Dadong Jia, Mingshuang Li, Mian Qin, Kaili Wu, Changying Yang, Jiabing Ran, Liang Liang   +6 more
doaj   +1 more source

The Calcineurin Inhibitor FK506 Prevents Cognitive Impairment by Inhibiting Reactive Astrogliosis in Pilocarpine-Induced Status Epilepticus Rats

Frontiers in Cellular Neuroscience, 2018
Status epilepticus (SE) is a severe clinical manifestation of epilepsy accompanying with cognitive impairment and brain damage. Astrocyte activation occurs following seizures and plays an important role in epilepsy-induced pathological injury, including ...
Jinzhi Liu, Zhihua Si, Shuqing Li, Zhan Huang, Yan He, Tao Zhang, Aihua Wang   +6 more
doaj   +1 more source

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Inhibition of Cytokine Production and Cytokine-Stimulated T-Cell Activation by FK506 (Tacrolimus)1

Cell Transplantation, 2001
Insofar as it exerted its immunosuppressive effect by inhibiting cytokine expression, we assessed the effect of FK506 (Tacrolimus) on cytokine-stimulated T-cell activation.
Wassim Y. Almawi, Joumana W. Assi, Dagmara M. Chudzik, Maroun M. Abou Jaoude, Michael J. Rieder   +4 more
doaj   +1 more source

Nuclear factor of activated T cells as a driver of tumor progression and a target for precision therapy

Animal Models and Experimental Medicine, EarlyView.
Overview illustration of dysregulated NFAT activation coordinating upstream signaling, post‐translational regulation and cancer promoting pathways to induce abnormal gene expression that drives tumor development, progression and immune escape. Abstract The Nuclear Factor of Activated T Cells (NFAT) family comprises closely related transcription factors.
Hira Khan, Khushbakhat Alia, Yusra Al Dhaheri, Muhammad Naseem, Rabah Iratni, Edgar Serfling, Khalid Muhammad   +6 more
wiley   +1 more source

Effects of FK506-binding Protein 12 and FK506 on Autophosphorylation of Epidermal Growth Factor Receptor [PDF]

Journal of Biological Chemistry, 1998
FK506-binding proteins and cyclophilins are intracellular proteins that express peptidylproline cis-trans-isomerase (PPIase) activity. The effects of FK506-binding protein 12 (FKBP12) and the cyclophilins 18 and 23 on autophosphorylation of the epidermal growth factor (EGF) receptor prepared from plasma membranes of the human epidermoid cell line A431 ...
M, Lopez-Ilasaca, C, Schiene, G, Küllertz, T, Tradler, G, Fischer, R, Wetzker   +5 more
openaire   +2 more sources