Results 61 to 70 of about 24,113 (230)

PRELIMINARY EXPERIENCE WITH FK506 IN THORACIC TRANSPLANTATION [PDF]

Transplantation, 1991
FK506, a potent immunosuppressive macrolide antibiotic, underwent initial clinical trails in liver recipients with intractable rejection or refractory drug toxicity (1,2). The dramatic results achieved by this agent in “rescue” therapy were followed shortly by its introduction as a primary immunosuppressant in kidney and liver recipients beginning in ...
Armitage, JM, Kormos, RL, Fung, J, Lavee, J, Fricker, FJ, Griffith, BP, Stuart, RS, Marrone, GC, Hardesty, RL, Todo, S, Tzakis, A, Starzl, TE   +11 more
openaire   +2 more sources

Illuminating Streptomyces: Raman Spectroscopy for Antibiotic Detection and Monitoring

Journal of Raman Spectroscopy, EarlyView.
Raman spectroscopy provides a non‐destructive, label‐free approach for studying the chemical diversity of Streptomyces. This review presents its application from detection to chemical characterization of secondary metabolites and monitoring of biosynthetic processes.
Adéla Mikulová, Jan Bobek, Martin Kizovský, Markéta Benešová, Ota Samek, Pavlína Modlitbová, Zdeněk Pilát   +6 more
wiley   +1 more source

Tacrolimus nanoparticles based on chitosan combined with nicotinamide: enhancing percutaneous delivery and treatment efficacy for atopic dermatitis and reducing dose

International Journal of Nanomedicine, 2017
Kaiyue Yu, Yixuan Wang, Tao Wan, Yuanhao Zhai, Sisi Cao, Wenyi Ruan, Chuanbin Wu, Yuehong Xu School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, People’s Republic of China Background: Topical application of tacrolimus (FK506 ...
Yu K, Wang Y, Wan T, Zhai Y, Cao S, Ruan W, Wu C, Xu Y   +7 more
doaj  

FK506-Binding Proteins and Their Diverse Functions [PDF]

Current Molecular Pharmacology, 2015
FK506 binding proteins (FKBPs) are a family of highly conserved proteins in eukaryotes. The prototype of this protein family, FKBP12, is the binding partner for immunosuppressive drugs FK506 and rapamycin. FKBP12 functions as a cis/trans peptidyl prolyl isomerase (PPIase) that catalyzes interconversion between prolyl cis/trans conformations. Members of
Mingming, Tong, Yu, Jiang
openaire   +2 more sources

Discovery of FK506-sensitive and FK506-insensitive genes for use in future clinical trials of novel immunosuppressant compounds

, 2003
FK 506 is an immunosuppressant drug used to treat autoimmune disease and to prevent organ graft rejection. The purpose of this project was to discover FK506-sensitive and FK506-insensitive genes.
Maska, Sara Michelle
core   +3 more sources

ER Stress via CHOP Pathway is Involved in FK506-Induced Apoptosis in Rat Fibroblasts

Cellular Physiology and Biochemistry, 2016
Background/Aims: Hypertrophic scars (HS) formation results from reduced apoptosis and increased proliferation of fibroblasts. Therefore, apoptosis of fibroblasts is a key target for the development of novel therapeutic strategies for HS. Previous reports
Jian Tang, Yingbin Ge, Lei Yang, Xinyu Xu, Tao Sui, Dawei Ge, Jun Que, Xiaojian Cao   +7 more
doaj   +1 more source

Organoid Coculture Models for Cancer Research and Immunotherapy

Med Research, EarlyView.
This review summarizes organoid coculture platforms, including submerged Matrigel culture, air–liquid interface, microfluidic/organoid‐on‐a‐chip, and 3D bioprinting, for reconstructing the tumor microenvironment to study tumor–stroma/immune crosstalk, evaluate immunotherapies, and enable drug screening.
Zhuo Yang, Huihui Yang, Guangxin Li, Guobang Liu, Zhulan Chen, Wenzhi Tian, Meiyang Huang, Xiaoling Liu, Yongsheng Zhao, Dong Chen   +9 more
wiley   +1 more source

Biosynthesis of Nonimmunosuppressive FK506 Analogues with Antifungal Activity

, 2021
A reduction in the strong immunosuppressive activity of FK506 (1) is essential for developing this compound as an antifungal agent. Seven new FK506 analogues modified at both the FK506-binding protein 12- and the calcineurin-binding regions were ...
남상집, 윤여준, 송명종
core   +1 more source

Molecular Glue Degraders in Early Development for Cancer Therapy

Medicinal Research Reviews, EarlyView.
ABSTRACT Molecular glue degraders are an emerging class of small molecule allosteric modulators that induce or stabilize protein‐protein interactions, enabling targeted degradation of previously intractable proteins. By redirecting E3 ligases to recognize neosubstrates, proteins that are not typically recognized by a specific E3 ubiquitin ligase, they ...
E. Sila Ozdemir, Hyunbum Jang, Ozlem Keskin, Attila Gursoy, Ruth Nussinov   +4 more
wiley   +1 more source

FK506 immunosuppression for submandibular salivary gland allotransplantation in rabbit

, 2020
Objectives: We compared the outcomes of two different doses of FK506 (tacrolimus) for immunosuppression in submandibular salivary gland (SMG) allotransplantation. Materials and Methods: Three SMG allotransplantation groups were established (n=6 per group)
Kim, Soung Min, Ju, Kyung Won, Lee, Jong-Ho, Kim, Bongju, Almansoori, Akram Abdo, Khentii, Namuun   +5 more
core   +1 more source