Results 81 to 90 of about 23,499 (227)

Catecholaminergic polymorphic ventricular tachycardia–linked ryanodine receptor variants exhibit domain‐specific calcium leak and calmodulin affinity properties

The Journal of Physiology, EarlyView.
Abstract figure legend Catecholaminergic polymorphic ventricular tachycardia (CPVT) variants in N terminal (NTD) and central domain (CD) but not pore domain induce a pathological RyR2 conformational shift upon protein kinase A (PKA) phosphorylation, similar to that seen in heart failure (HF), calcium/calmodulin‐dependent protein kinase II (CaMKII ...
Hitoshi Uchinoumi, Xiaoqiong Dong, Ivanita Stefanon, Yi Yang, Eduardo Hertel Ribeiro, Bengt Svensson, Xander H. T. Wehrens, Takeshi Yamamoto, Razvan L. Cornea, Robyn T. Rebbeck, Masafumi Yano, Donald M. Bers   +11 more
wiley   +1 more source

Fk506 Inhibits Tumour Necrosis Factor-α Secretion in Human Keratinocytes Via Regulation of Nuclear Factor-κb

, 2009
Background Tacrolimus (FK506) ointment has been used for treatment of inflammatory dermatoses with remarkable success . Our previous studies have indicated that direct modulation of tacrolimus on keratinocytes (KCs) may have an impact on its therapeutic ...
YU, HSIN-SU, 余幸司
core  

Characterization of FK506 biosynthetic intermediates involved in post-PKS elaboration

, 2021
The post-PKS modification steps of FK506 biosynthesis include C9-oxidation and 31-O-methylation, but the sequence of these reactions and the exact route have remained unclear.
Pramod B. Shinde, 윤여준, 송명종
core   +1 more source

Immunosuppressive drug interactions and resistance in mononuclear cells from renal transplant patients [PDF]

Existing anti-rejection drug regimes are inadequate since patients receive drugs despite serious side effects and poor response. New drugs are being developed which ultimately may allow for prescribing of rational, patient-specific immunosuppressive ...
Delaney, Michael Paul
core  

Antioxidant supplementation blunts the proteome response to 3 weeks of sprint interval training preferentially in human type 2 muscle fibres

The Journal of Physiology, EarlyView.
Abstract figure legend Sprint interval training (SIT) is a popular time‐efficient type of endurance training. Healthy young men performed nine SIT sessions (4–6 × 30 s all‐out cycling sprints) over 3 weeks while being supplemented with antioxidants (high doses of vitamins C and E) or placebo. Muscle biopsies taken before and after the first SIT session
Victoria L. Wyckelsma, Marta Murgia, Sigitas Kamandulis, Stefano Gastaldello, Marius Brazaitis, Audrius Snieckus, Nerijus Eimantas, Mati Pääsuke, Sebastian Edman, William Apro, Daniel C. Andersson, Håkan Westerblad, Tomas Venckunas   +12 more
wiley   +1 more source

Optimization of Immunosuppressive Therapy for Spinal Grafting of Human Spinal Stem Cells in a Rat Model of ALS

Cell Transplantation, 2011
Previous rodent studies employing monotherapy or combined immunosuppressive regimens have demonstrated a variable degree of spinal xenograft survival in several spinal neurodegenerative models including spinal ischemia, trauma, or amyotrophic lateral ...
Michael P. Hefferan Ph.D., Karl Johe, Thomas Hazel, Eva L. Feldman, J. Simon Lunn, Martin Marsala   +5 more
doaj   +1 more source

Detection of Protein–Protein Interactions in Escherichia coli With Single Molecule Sensitivity

Advanced Science, Volume 13, Issue 37, 3 July 2026.
This article describes a regulatory circuit in Escherichia coli able to detect protein–protein interactions with exquisite sensitivity. The interaction between two hybrid proteins fused to Bordetella pertussis adenylate cyclase and its activator calmodulin triggers a potent cyclic AMP signaling cascade.
Marilyne Davi, Daniel Ladant
wiley   +1 more source

FK506 protects against articular cartilage collagenous extra-cellular matrix degradation [PDF]

, 2014
Objective: Osteoarthritis (OA) is a non-rheumatologic joint disease characterized by progressive degeneration of the cartilage extra-cellular matrix (ECM), enhanced subchondral bone remodeling, activation of synovial macrophages and osteophyte growth ...
Groen, Harald, van der Windt, A.E., Waarsing, J. H., Waarsing, J.H. (Jan), Windt, A.E. (Anna) van der, van der Windt, A. E., Müller, Caspar, Sandker, M. (Marjan), Weinans, H., Jahr, Holger, Sandker, Marjan, Jahr, H. (Holger), Groen, H.C., Jong, Marion, Siebelt, M. (Michiel), Jahr, H., Müller, C. (Cristina), Weinans, H.H. (Harrie), Groen, H.C. (Harald), Waarsing, Jan, Siebelt, Michiel, Groen, H. C., Jong, M. (Marcel) de, Sandker, M., de Jong, M., Waarsing, J.H., Müller, C., Weinans, HH, Siebelt, M., Windt, Anna   +29 more
core   +1 more source

Serum Eosinophil‐Derived Neurotoxin (EDN) as a Biomarker for Treatment Response in Atopic Dermatitis

Clinical &Experimental Allergy, EarlyView.
J. I. Olydam, S. Sengkerij, S. Veenbergen, D. J. Hijnen   +3 more
wiley   +1 more source

Combining Fret and Super‐Resolution Microscopy Reveals Kinase Activation and Mitochondrial Activity at the Nanoscale

Advanced Science, Volume 13, Issue 37, 3 July 2026.
BioSenSRRF is an open‐source workflow that combines conventional FRET biosensors with SRRF reconstruction to generate sub‐diffraction FRET index maps on standard microscopes. The pipeline integrates automated image registration, SRRF reconstruction, quantitative FRET index calculation, and random line‐based hotspot analysis to uncover AURKA‐dependent ...
Nicolas Y. Jolivet, Pierre‐Jean Desmaison, Xavier Pinson, Arthur Masson, Olivier Delalande, Giulia Bertolin   +5 more
wiley   +1 more source